iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-107646

Ensembl Protein ID

ENSSHAP00000005074.1

UniProt Accession

G3VPG9; G3VPG9_SARHA

Genbank Protein ID

ENSSHAP00000005074

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01181260

Gene Name

HDAC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000004439.1	ENSSHAT00000005124.1	ENSSHAP00000005074.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	66.70	0.00e+00	983.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
609	N/A	{ECO:0000256\|PIRSR:PIRSR037911-1}

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

KTQHSSLDQS SPPQSGGPAA YNHPVLGMYD SKDDFPLRKT ASEPNLKLRS RLKQKVAERR 60
SSPLLRRKDG PVVTALKKRP LDVTDSACSS APGSGPSSPN NSSNNVSAEN GIAGSVASIQ 120

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Nucleotide Sequence
(Fasta)

AAAACCCAGC ACAGTTCCCT GGACCAGAGC TCGCCCCCCC AGAGCGGGGG CCCCGCAGCC 60
TACAATCACC CGGTGCTGGG CATGTATGAC TCCAAAGACG ACTTTCCTCT TCGAAAAACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom

Pfam

PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0042641--C:actomyosin
GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0031594--C:neuromuscular junction
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0004407--F:histone deacetylase activity
GO:0030955--F:potassium ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0070932--P:histone H3 deacetylation
GO:0070933--P:histone H4 deacetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045820--P:negative regulation of glycolytic process
GO:0010832--P:negative regulation of myotube differentiation
GO:0045668--P:negative regulation of osteoblast differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0002076--P:osteoblast development
GO:0034983--P:peptidyl-lysine deacetylation
GO:0008284--P:positive regulation of cell proliferation
GO:0033235--P:positive regulation of protein sumoylation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010882--P:regulation of cardiac muscle contraction by calcium ion signaling
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0048742--P:regulation of skeletal muscle fiber development
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0070555--P:response to interleukin-1
GO:0001501--P:skeletal system development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002279	Ailuropoda melanoleuca	65.70	0.00e+00	982.00
IUUC-Apl-003250	Anas platyrhynchos	66.48	0.00e+00	989.00
IUUC-Aca-004668	Anolis carolinensis	64.75	0.00e+00	942.00
IUUC-Ang-009522	Aspergillus niger	31.16	2.00e-29	124.00
IUUC-Bta-013215	Bos taurus	65.95	0.00e+00	949.00
IUUC-Cja-019816	Callithrix jacchus	66.52	0.00e+00	964.00
IUUC-Cfa-020861	Canis familiaris	65.97	0.00e+00	942.00
IUUC-Cpo-021562	Cavia porcellus	65.13	0.00e+00	956.00
IUUC-Csa-023612	Chlorocebus sabaeus	65.95	0.00e+00	936.00
IUUC-Csv-026359	Ciona savignyi	53.04	8.00e-89	319.00
IUUC-Dre-028284	Danio rerio	69.79	3.00e-173	602.00
IUUC-Dno-029951	Dasypus novemcinctus	63.65	0.00e+00	857.00
IUUC-Dor-030362	Dipodomys ordii	70.57	9.00e-129	454.00
IUUC-Dme-031766	Drosophila melanogaster	51.21	6.00e-122	432.00
IUUC-Fca-036187	Felis catus	66.63	0.00e+00	984.00
IUUC-Gmo-038473	Gadus morhua	83.54	3.00e-163	568.00
IUUC-Gga-040501	Gallus gallus	66.92	0.00e+00	992.00
IUUC-Gac-042335	Gasterosteus aculeatus	66.89	5.00e-166	578.00
IUUC-Ggo-045380	Gorilla gorilla	66.06	0.00e+00	933.00
IUUC-Hsa-046925	Homo sapiens	66.63	0.00e+00	972.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	66.06	0.00e+00	921.00
IUUC-Lch-050325	Latimeria chalumnae	62.11	0.00e+00	865.00
IUUC-Loc-052231	Lepisosteus oculatus	61.44	0.00e+00	849.00
IUUC-Laf-054490	Loxodonta africana	64.59	0.00e+00	953.00
IUUC-Mcc-055265	Macaca mulatta	66.37	0.00e+00	967.00
IUUC-Meu-056676	Macropus eugenii	55.58	2.00e-112	400.00
IUUC-Mmr-061633	Microcebus murinus	61.58	0.00e+00	820.00
IUUC-Mmu-063089	Mus musculus	65.55	0.00e+00	939.00
IUUC-Mpu-065887	Mustela putorius furo	66.55	0.00e+00	983.00
IUUC-Mlu-067470	Myotis lucifugus	66.97	0.00e+00	983.00
IUUC-Nle-069099	Nomascus leucogenys	70.90	3.00e-98	352.00
IUUC-Ont-071613	Oreochromis niloticus	67.96	2.00e-168	587.00
IUUC-Oan-073275	Ornithorhynchus anatinus	67.65	0.00e+00	979.00
IUUC-Ola-087031	Oryzias latipes	82.76	1.00e-161	563.00
IUUC-Oga-088201	Otolemur garnettii	70.87	0.00e+00	636.00
IUUC-Oar-089997	Ovis aries	62.72	0.00e+00	902.00
IUUC-Ptr-091116	Pan troglodytes	66.70	0.00e+00	977.00
IUUC-Pan-092132	Papio anubis	60.24	0.00e+00	662.00
IUUC-Psi-093734	Pelodiscus sinensis	69.18	0.00e+00	650.00
IUUC-Pma-094347	Petromyzon marinus	74.37	3.00e-148	519.00
IUUC-Pfo-096293	Poecilia formosa	71.46	3.00e-164	572.00
IUUC-Pab-098491	Pongo abelii	62.85	0.00e+00	871.00
IUUC-Pca-101004	Procavia capensis	51.29	2.00e-111	396.00
IUUC-Pva-102961	Pteropus vampyrus	55.25	9.00e-79	288.00
IUUC-Rno-105005	Rattus norvegicus	66.29	0.00e+00	949.00
IUUC-Ssc-115428	Sus scrofa	65.28	0.00e+00	953.00
IUUC-Tgu-116776	Taeniopygia guttata	66.52	0.00e+00	994.00
IUUC-Tru-118180	Takifugu rubripes	72.29	6.00e-166	578.00
IUUC-Tsy-119468	Tarsius syrichta	49.64	3.00e-120	426.00
IUUC-Tni-120196	Tetraodon nigroviridis	70.86	1.00e-165	577.00
IUUC-Ttr-128360	Tursiops truncatus	79.24	0.00e+00	634.00
IUUC-Xtr-132956	Xenopus tropicalis	59.87	0.00e+00	848.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence