iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132210

Ensembl Protein ID

ENSXETP00000051330.3

UniProt Accession

F7E9T8; F7E9T8_XENTR

Genbank Protein ID

ENSXETP00000051330

Protein Name

Hypermethylated in cancer 1

Genbank Nucleotide ID

AAMC01066656

Gene Name

hic1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000023803.3	ENSXETT00000051330.3	ENSXETP00000051330.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.30e-12	48.1	28	87

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveik.d.vqpevfrallkFlYtgkl 65
           +Dvi+vv++  f+ahk +LaasS ++++l  +        + ++++ d v+p+ fr +l+++Ytg+l
   Q: 28   CDVIIVVQNALFRAHKNILAASSVYLKSLVVH-------DNLINLDhDmVSPSIFRIILDYIYTGRL 87
           9*****************************66.......5789999889****************98 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MLDAMEVPSH SRQLLLQLNS QRTKGFLCDV IIVVQNALFR AHKNILAASS VYLKSLVVHD 60
NLINLDHDMV SPSIFRIILD YIYTGRLGDG EPTSEQLFGA VLAAASYLQI TDLVSMCKKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTGGACG CTATGGAGGT TCCAAGTCAC TCAAGGCAAC TTCTTCTCCA GCTCAATAGC 60
CAACGGACTA AGGGCTTCCT GTGCGATGTG ATCATTGTGG TACAGAACGC TCTGTTTAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000210--BTB/POZ_dom
IPR028424--HIC1
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005622--C:intracellular
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001347	Ailuropoda melanoleuca	61.58	2.00e-109	389.00
IUUC-Aca-004680	Anolis carolinensis	60.15	4.00e-74	272.00
IUUC-Ame-010967	Astyanax mexicanus	52.79	0.00e+00	635.00
IUUC-Bta-013567	Bos taurus	60.59	8.00e-110	390.00
IUUC-Cja-019621	Callithrix jacchus	86.67	2.00e-39	154.00
IUUC-Cfa-020731	Canis familiaris	57.16	9.00e-175	607.00
IUUC-Cpo-021326	Cavia porcellus	57.74	0.00e+00	634.00
IUUC-Csa-023645	Chlorocebus sabaeus	56.04	1.00e-175	609.00
IUUC-Dre-028027	Danio rerio	63.01	2.00e-111	396.00
IUUC-Dno-028900	Dasypus novemcinctus	56.12	0.00e+00	630.00
IUUC-Fal-036980	Ficedula albicollis	69.17	0.00e+00	825.00
IUUC-Gga-040708	Gallus gallus	73.15	0.00e+00	890.00
IUUC-Gac-041742	Gasterosteus aculeatus	56.57	5.00e-160	557.00
IUUC-Hsa-046769	Homo sapiens	55.91	2.00e-173	602.00
IUUC-Itr-048627	Ictidomys tridecemlineatus	60.10	2.00e-111	396.00
IUUC-Lch-049412	Latimeria chalumnae	74.18	0.00e+00	974.00
IUUC-Laf-053358	Loxodonta africana	60.34	6.00e-112	398.00
IUUC-Mcc-054981	Macaca mulatta	56.04	2.00e-175	608.00
IUUC-Meu-056181	Macropus eugenii	51.45	4.00e-84	305.00
IUUC-Mga-059592	Meleagris gallopavo	84.97	6.00e-141	493.00
IUUC-Mmr-061560	Microcebus murinus	55.54	8.00e-177	613.00
IUUC-Mdo-062511	Monodelphis domestica	54.51	1.00e-156	546.00
IUUC-Mmu-064258	Mus musculus	60.34	2.00e-112	400.00
IUUC-Mpu-065911	Mustela putorius furo	57.08	1.00e-176	612.00
IUUC-Ont-072493	Oreochromis niloticus	56.41	6.00e-107	381.00
IUUC-Ola-086584	Oryzias latipes	68.71	1.00e-105	377.00
IUUC-Oga-088774	Otolemur garnettii	56.97	0.00e+00	641.00
IUUC-Pfo-096282	Poecilia formosa	53.10	8.00e-174	603.00
IUUC-Pab-098488	Pongo abelii	55.51	2.00e-111	395.00
IUUC-Pva-102421	Pteropus vampyrus	60.49	8.00e-115	407.00
IUUC-Rno-105528	Rattus norvegicus	55.30	2.00e-172	598.00
IUUC-Sar-113478	Sorex araneus	72.22	2.00e-88	320.00
IUUC-Ssc-115420	Sus scrofa	59.95	5.00e-115	408.00
IUUC-Tgu-116642	Taeniopygia guttata	73.46	0.00e+00	877.00
IUUC-Tru-118583	Takifugu rubripes	52.47	1.00e-169	589.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence