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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045752
UUCD1 version UUC-HoS-00192
Ensembl Protein ID ENSP00000373752.4
UniProt Accession Q86T96; Q0JSU3; Q495A8; Q8NBD1; RN180_HUMAN
Genbank Protein ID BAC03514.1; CAD89939.1; AAI01278.1; AAI01279.1; AAI01280.1; AAI01398.1
Protein Name E3 ubiquitin-protein ligase RNF180; RING finger protein 180; RING-type E3 ubiquitin transferase RNF180
Genbank Nucleotide ID AK090756; AL832580; BC101277; BC101278; BC101279; BC101397
Gene Name RNF180
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000164197.11 ENST00000296615.10 ENSP00000296615.6
ENSG00000164197.11 ENST00000389100.8 ENSP00000373752.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPA
DNA & RNA Element
UTRdbAREsiteCircNetmicroRNA
TRANSFACTargetScanRepTarmiRcode
RAID2
Protein-protein Interaction
IIDMentha
Disease-associated Information
ClinVarOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18363970; 18358233
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.0024 20.0 432 474
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+Cl+ +++++++ pC H+f++ Cl  +    +    +  CPlCr
   Q: 432  CAVCLDVYFNPYMCYPCHHIFCEPCLRTL---AKDNPSSTPCPLCR 474
           **********9999************777...445777778****8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2.
 E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2.
Protein Sequence
(Fasta)
MKRSKELITK NHSQEETSIL RCWKCRKCIA SSGCFMEYLE NQVIKDKDDS VDAQNICHVW 60
HMNVEALPEW ISCLIQKAQW TVGKLNCPFC GARLGGFNFV STPKCSCGQL AAVHLSKSRT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045752|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AACCGGCATC GCCGCCGCCG GAGCCGCAGC GAGTCCTCAG AGCCTGGCTG CTGGCGGCCG 60
GGAGCGCCGG GACGGGGCGC GAAGCCGGAG GCTCCGGGAC GTGGATACAG GTAAAGGCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045752|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR033263--RNF180
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
SMART

SM00184--RING
Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005622--C:intracellular
GO:0031227--C:intrinsic component of endoplasmic reticulum membrane
GO:0005635--C:nuclear envelope
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0030534--P:adult behavior
GO:0042415--P:norepinephrine metabolic process
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398--P:positive regulation of protein ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0050790--P:regulation of catalytic activity
GO:0042428--P:serotonin metabolic process
KEGG hsa:285671
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002250 Ailuropoda melanoleuca 84.60 0.00e+00 1001.00
IUUC-Apl-003598 Anas platyrhynchos 52.61 6.00e-149 521.00
IUUC-Aca-004364 Anolis carolinensis 46.99 2.00e-137 483.00
IUUC-Ame-011498 Astyanax mexicanus 66.67 6.00e-69 253.00
IUUC-Bta-012990 Bos taurus 85.47 0.00e+00 1019.00
IUUC-Bci-013759 Botrytis cinerea 28.21 5.00e-04 39.30
IUUC-Cja-019420 Callithrix jacchus 94.29 0.00e+00 1088.00
IUUC-Cfa-020028 Canis familiaris 85.64 0.00e+00 1021.00
IUUC-Cpo-021698 Cavia porcellus 81.44 0.00e+00 803.00
IUUC-Csa-023637 Chlorocebus sabaeus 92.21 0.00e+00 1089.00
IUUC-Cho-025073 Choloepus hoffmanni 72.22 0.00e+00 823.00
IUUC-Dre-027523 Danio rerio 72.37 1.00e-69 256.00
IUUC-Dno-030040 Dasypus novemcinctus 79.34 0.00e+00 756.00
IUUC-Dor-030405 Dipodomys ordii 84.46 0.00e+00 971.00
IUUC-Eca-033366 Equus caballus 87.37 0.00e+00 1058.00
IUUC-Fca-035526 Felis catus 86.38 0.00e+00 787.00
IUUC-Fal-037590 Ficedula albicollis 48.60 3.00e-142 498.00
IUUC-Gmo-039484 Gadus morhua 52.63 6.00e-44 171.00
IUUC-Gga-040136 Gallus gallus 49.91 3.00e-148 518.00
IUUC-Gac-041811 Gasterosteus aculeatus 50.94 1.00e-42 167.00
IUUC-Ggo-044673 Gorilla gorilla 98.10 0.00e+00 1144.00
IUUC-Itr-047971 Ictidomys tridecemlineatus 88.06 0.00e+00 1056.00
IUUC-Lch-050309 Latimeria chalumnae 47.09 1.00e-130 460.00
IUUC-Loc-052203 Lepisosteus oculatus 45.58 2.00e-122 432.00
IUUC-Laf-053398 Loxodonta africana 84.08 0.00e+00 999.00
IUUC-Mcc-054745 Macaca mulatta 97.23 0.00e+00 1130.00
IUUC-Mmr-060583 Microcebus murinus 91.87 0.00e+00 1102.00
IUUC-Mdo-062873 Monodelphis domestica 67.81 0.00e+00 761.00
IUUC-Mmu-063393 Mus musculus 79.73 0.00e+00 798.00
IUUC-Mac-065655 Musa acuminata 36.84 2.00e-07 50.40
IUUC-Mpu-066186 Mustela putorius furo 83.94 0.00e+00 993.00
IUUC-Mlu-068079 Myotis lucifugus 81.90 0.00e+00 967.00
IUUC-Nle-069164 Nomascus leucogenys 98.27 0.00e+00 1146.00
IUUC-Opr-070362 Ochotona princeps 77.18 0.00e+00 880.00
IUUC-Oan-072729 Ornithorhynchus anatinus 36.02 2.00e-47 183.00
IUUC-Ocu-073894 Oryctolagus cuniculus 77.59 0.00e+00 725.00
IUUC-Oga-088485 Otolemur garnettii 90.31 0.00e+00 1043.00
IUUC-Oar-089831 Ovis aries 85.29 0.00e+00 1016.00
IUUC-Ptr-091570 Pan troglodytes 98.96 0.00e+00 1154.00
IUUC-Psi-093962 Pelodiscus sinensis 54.83 1.00e-173 603.00
IUUC-Pfo-096369 Poecilia formosa 68.55 8.00e-64 237.00
IUUC-Pab-098224 Pongo abelii 81.83 0.00e+00 889.00
IUUC-Pca-100186 Procavia capensis 76.64 0.00e+00 851.00
IUUC-Pva-102511 Pteropus vampyrus 88.06 0.00e+00 1058.00
IUUC-Rno-105170 Rattus norvegicus 79.97 0.00e+00 914.00
IUUC-Sha-107501 Sarcophilus harrisii 70.15 0.00e+00 707.00
IUUC-Sja-107944 Schizosaccharomyces japonicus 44.44 4.00e-07 48.50
IUUC-Ssc-115668 Sus scrofa 86.15 0.00e+00 928.00
IUUC-Tgu-117098 Taeniopygia guttata 50.19 2.00e-139 489.00
IUUC-Tru-118625 Takifugu rubripes 70.07 1.00e-62 231.00
IUUC-Tsy-118959 Tarsius syrichta 89.62 0.00e+00 1033.00
IUUC-Tni-120324 Tetraodon nigroviridis 32.71 7.00e-62 231.00
IUUC-Tbe-127448 Tupaia belangeri 84.95 0.00e+00 873.00
IUUC-Ttr-128470 Tursiops truncatus 84.60 0.00e+00 974.00
IUUC-Vpa-130097 Vicugna pacos 86.12 0.00e+00 949.00
IUUC-Xtr-132848 Xenopus tropicalis 42.83 7.00e-114 404.00
Created Date 25-Jun-2017

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