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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046640
Ensembl Protein ID ENSP00000355343.2
UniProt Accession Q14157; B4E0U8; Q5VU75; Q5VU76; Q9BTU3; Q9UGL2; Q9UGL3; Q9UGL4; Q9UGL5; UBP2L_HUMAN
Genbank Protein ID BAA09765.1; BAG64560.1; CAH71283.1; CAH71284.1; CAH71285.1; AAH03170.1; CAB65099.1; CAB65101.2; CAB65100.2
Protein Name Ubiquitin-associated protein 2-like; Protein NICE-4
Genbank Nucleotide ID D63478; AK303533; AL590431; AL590431; AL590431; BC003170; AJ243668; AJ243670; AJ243669
Gene Name UBAP2L; KIAA0144; NICE4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000143569.18 ENST00000343815.10 ENSP00000345308.6
ENSG00000143569.18 ENST00000361546.6 ENSP00000355343.2
ENSG00000143569.18 ENST00000433615.5 ENSP00000407672.1
ENSG00000143569.18 ENST00000428595.1 ENSP00000398609.1
ENSG00000143569.18 ENST00000613315.4 ENSP00000478447.1
ENSG00000143569.18 ENST00000271877.11 ENSP00000271877.8
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 25185265; 26310274
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 7.20e-07 30.8 50 89
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 3    dedkleqlve.MGFdreealqaLraannnleaAveyLldg 41
           +e+k+ ql++ +G +++e++ aL ++n+++++A++ Ll+g
   Q: 50   FEEKVKQLIDiTGKNQDECVIALHDCNGDVNRAINVLLEG 89
           79***********************************986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs).
 Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs).
Protein Sequence
(Fasta)
MMTSVGTNRA RGNWEQPQNQ NQTQHKQRPQ ATAEQIRLAQ MISDHNDADF EEKVKQLIDI 60
TGKNQDECVI ALHDCNGDVN RAINVLLEGN PDTHSWEMVG KKKGVSGQKD GGQTESNEEG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046640|UBD,UBA|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCCGACTAAG TGACTTAAAC TCCCACCTAC TCCTGGAATA AGGAGTCAAA GCCCGGATAG 60
GCGCAGGTGA GTGGGTGGAG AATGCAGACG GGGTACAGCT CAAAAGGAGG GTCTCTACTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046640|UBD,UBA|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
Interpro

IPR022166--DUF3697_Uba2
IPR015940--UBA
IPR009060--UBA-like
PROSITE

PS50030--UBA
Pfam

PF12478--DUF3697
SMART

SM00165--UBA
Gene Ontology

GO:0005737--C:cytoplasm
GO:0031519--C:PcG protein complex
GO:0003723--F:RNA binding
GO:0007339--P:binding of sperm to zona pellucida
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0010628--P:positive regulation of gene expression
KEGG hsa:9898
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002224 Ailuropoda melanoleuca 95.93 0.00e+00 1279.00
IUUC-Apl-003891 Anas platyrhynchos 87.59 0.00e+00 773.00
IUUC-Aca-004775 Anolis carolinensis 71.21 2.00e-120 426.00
IUUC-Ani-009287 Aspergillus nidulans 40.54 3.20e-02 34.30
IUUC-Ang-009672 Aspergillus niger 43.24 1.80e-02 33.50
IUUC-Ame-011168 Astyanax mexicanus 56.63 8.00e-139 488.00
IUUC-Bta-012828 Bos taurus 98.66 0.00e+00 1145.00
IUUC-Cja-019745 Callithrix jacchus 96.34 0.00e+00 1296.00
IUUC-Cfa-021052 Canis familiaris 97.79 0.00e+00 1285.00
IUUC-Cpo-021884 Cavia porcellus 96.57 0.00e+00 1285.00
IUUC-Cho-024952 Choloepus hoffmanni 92.87 0.00e+00 796.00
IUUC-Cin-025284 Ciona intestinalis 41.05 2.00e-14 74.70
IUUC-Dre-027917 Danio rerio 57.93 3.00e-137 483.00
IUUC-Dno-028928 Dasypus novemcinctus 95.19 0.00e+00 809.00
IUUC-Dor-031085 Dipodomys ordii 100.00 7.00e-124 438.00
IUUC-Eca-033794 Equus caballus 96.39 0.00e+00 1303.00
IUUC-Eeu-035149 Erinaceus europaeus 89.90 0.00e+00 1117.00
IUUC-Fca-036151 Felis catus 96.79 0.00e+00 845.00
IUUC-Fal-037010 Ficedula albicollis 83.82 0.00e+00 763.00
IUUC-Gmo-038568 Gadus morhua 64.04 4.00e-97 350.00
IUUC-Gga-040927 Gallus gallus 85.46 0.00e+00 775.00
IUUC-Gac-042377 Gasterosteus aculeatus 67.11 1.00e-110 394.00
IUUC-Ggo-045228 Gorilla gorilla 99.71 0.00e+00 897.00
IUUC-Itr-048492 Ictidomys tridecemlineatus 97.00 0.00e+00 890.00
IUUC-Lch-050547 Latimeria chalumnae 78.88 0.00e+00 708.00
IUUC-Loc-051792 Lepisosteus oculatus 72.20 3.00e-131 463.00
IUUC-Laf-054557 Loxodonta africana 94.80 0.00e+00 868.00
IUUC-Mcc-055019 Macaca mulatta 99.85 0.00e+00 898.00
IUUC-Meu-056728 Macropus eugenii 98.95 7.00e-117 415.00
IUUC-Mga-059865 Meleagris gallopavo 78.30 0.00e+00 675.00
IUUC-Mmr-061272 Microcebus murinus 99.27 0.00e+00 901.00
IUUC-Mdo-062882 Monodelphis domestica 93.02 0.00e+00 837.00
IUUC-Mmu-064078 Mus musculus 94.53 0.00e+00 862.00
IUUC-Mpu-066636 Mustela putorius furo 95.87 0.00e+00 917.00
IUUC-Mlu-067554 Myotis lucifugus 97.98 0.00e+00 1305.00
IUUC-Nle-069820 Nomascus leucogenys 99.71 0.00e+00 897.00
IUUC-Opr-070427 Ochotona princeps 85.37 3.00e-173 603.00
IUUC-Ont-071731 Oreochromis niloticus 63.03 2.00e-123 437.00
IUUC-Ocu-073849 Oryctolagus cuniculus 93.43 0.00e+00 1251.00
IUUC-Ola-087073 Oryzias latipes 57.06 2.00e-139 489.00
IUUC-Oga-088352 Otolemur garnettii 93.64 0.00e+00 1135.00
IUUC-Oar-089189 Ovis aries 98.25 0.00e+00 929.00
IUUC-Ptr-090471 Pan troglodytes 99.85 0.00e+00 899.00
IUUC-Pan-091960 Papio anubis 89.58 0.00e+00 811.00
IUUC-Psi-093123 Pelodiscus sinensis 83.50 0.00e+00 758.00
IUUC-Pfo-096779 Poecilia formosa 64.53 1.00e-114 408.00
IUUC-Pab-097725 Pongo abelii 99.42 0.00e+00 897.00
IUUC-Pca-100364 Procavia capensis 89.46 4.00e-164 572.00
IUUC-Pva-103206 Pteropus vampyrus 97.21 0.00e+00 837.00
IUUC-Rno-104849 Rattus norvegicus 94.53 0.00e+00 879.00
IUUC-Sha-107007 Sarcophilus harrisii 92.09 0.00e+00 820.00
IUUC-Sar-113554 Sorex araneus 95.87 0.00e+00 1255.00
IUUC-Ssc-116394 Sus scrofa 98.11 0.00e+00 891.00
IUUC-Tgu-116920 Taeniopygia guttata 83.82 0.00e+00 771.00
IUUC-Tru-117891 Takifugu rubripes 56.31 3.00e-159 556.00
IUUC-Tsy-119473 Tarsius syrichta 95.55 0.00e+00 669.00
IUUC-Tni-120870 Tetraodon nigroviridis 48.30 2.00e-121 430.00
IUUC-Tbe-127249 Tupaia belangeri 86.12 1.00e-140 494.00
IUUC-Ttr-128196 Tursiops truncatus 89.31 0.00e+00 682.00
IUUC-Vpa-130530 Vicugna pacos 96.66 0.00e+00 857.00
IUUC-Xtr-132315 Xenopus tropicalis 70.46 0.00e+00 717.00
Created Date 25-Jun-2017

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