iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046597

UUCD1 version

UUC-HoS-00285

Ensembl Protein ID

ENSP00000264198.3

UniProt Accession

Q969V5; B5M497; Q7Z431; Q9H9B5; MUL1_HUMAN

Genbank Protein ID

ACH72645.1; BAC77368.1; BAB14317.1; CAD38745.1; AAH10101.1; AAH14010.1

Protein Name

Mitochondrial ubiquitin ligase activator of NFKB 1; E3 SUMO-protein ligase MUL1; E3 ubiquitin-protein ligase MUL1; Growth inhibition and death E3 ligase; Mitochondrial-anchored protein ligase; Putative NF-kappa-B-activating protein 266; RING finger protein 218; RING-type E3 ubiquitin transferase NFKB 1

Genbank Nucleotide ID

EU935008; AB097015; AK022937; AL833889; AL391357; BC014010

Gene Name

MUL1; C1orf166; GIDE; MAPL; MULAN; RNF218

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000090432.6	ENST00000264198.4	ENSP00000264198.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19741096; 19525920; 19407830; 20103533; 22410793; 26018823

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.047	15.9	302	340

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgH.vfhadClqkwpglknssskefrCPlCr 46
           C +Cl++fk   ++l CgH + +++C        +      +CP+Cr
   Q: 302  CVVCLSSFKS-CVFLECGHvCSCTECY-------RALPEPKKCPICR 340
           ********99.666*****555****4.......44688889****8 PP

Organism

Homo sapiens

Functional Description
(View)

Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. The function may implicate its ability to sumoylate DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination.

Protein Sequence
(Fasta)

MESGGRPSLC QFILLGTTSV VTAALYSVYR QKARVSQELK GAKKVHLGED LKSILSEAPG 60
KCVPYAVIEG AVRSVKETLN SQFVENCKGV IQRLTLQEHK MVWNRTTHLW NDCSKIIHQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCGCTGGGC GACTGATTTC GAGTTTCCGG TCAGGTTAGG CCGGGGGGGT GCGGTCCTGG 60
TCGGAAGGAG GTGGAGAGTC GGGGGTCACC AGGCCTATCC TTGGCGCCAC AGTCGGCCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-0576--Peroxisome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001370--BIR_rpt
IPR022170--GIDE
IPR001841--Znf_RING

PROSITE

PS50089--ZF_RING_2

Pfam

PF12483--GIDE

Gene Ontology

GO:0030424--C:axon
GO:0031307--C:integral component of mitochondrial outer membrane
GO:0016020--C:membrane
GO:0005739--C:mitochondrion
GO:0043025--C:neuronal cell body
GO:0005777--C:peroxisome
GO:0042802--F:identical protein binding
GO:0004871--F:signal transducer activity
GO:0019789--F:SUMO transferase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007257--P:activation of JUN kinase activity
GO:0006915--P:apoptotic process
GO:0071360--P:cellular response to exogenous dsRNA
GO:0000266--P:mitochondrial fission
GO:0051646--P:mitochondrion localization
GO:0030308--P:negative regulation of cell growth
GO:0071650--P:negative regulation of chemokine (C-C motif) ligand 5 production
GO:0050689--P:negative regulation of defense response to virus by host
GO:0045824--P:negative regulation of innate immune response
GO:0010637--P:negative regulation of mitochondrial fusion
GO:0051898--P:negative regulation of protein kinase B signaling
GO:0060339--P:negative regulation of type I interferon-mediated signaling pathway
GO:1903861--P:positive regulation of dendrite extension
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0090141--P:positive regulation of mitochondrial fission
GO:1904925--P:positive regulation of mitophagy in response to mitochondrial depolarization
GO:0033235--P:positive regulation of protein sumoylation
GO:0031648--P:protein destabilization
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:0051881--P:regulation of mitochondrial membrane potential
GO:1901028--P:regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:0010821--P:regulation of mitochondrion organization

KEGG

hsa:79594

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000342	Aegilops tauschii	25.32	7.00e-13	69.70
IUUC-Aml-002287	Ailuropoda melanoleuca	92.90	0.00e+00	652.00
IUUC-Atr-002698	Amborella trichopoda	24.58	5.00e-09	55.50
IUUC-Aca-005039	Anolis carolinensis	37.79	2.00e-63	236.00
IUUC-Aly-006181	Arabidopsis lyrata	28.65	2.00e-22	99.80
IUUC-Ath-007438	Arabidopsis thaliana	28.94	3.00e-23	102.00
IUUC-Ame-010671	Astyanax mexicanus	62.22	2.00e-132	465.00
IUUC-Bta-012407	Bos taurus	80.74	2.00e-166	578.00
IUUC-Bdi-014735	Brachypodium distachyon	25.15	9.00e-18	84.30
IUUC-Bol-015493	Brassica oleracea	27.22	7.00e-24	104.00
IUUC-Bra-016933	Brassica rapa	26.95	4.00e-20	92.40
IUUC-Cja-019709	Callithrix jacchus	98.13	0.00e+00	655.00
IUUC-Cfa-020818	Canis familiaris	94.03	0.00e+00	667.00
IUUC-Cpo-022490	Cavia porcellus	93.18	0.00e+00	638.00
IUUC-Csa-023259	Chlorocebus sabaeus	100.00	0.00e+00	728.00
IUUC-Cho-024730	Choloepus hoffmanni	94.60	0.00e+00	688.00
IUUC-Cin-025301	Ciona intestinalis	30.82	2.00e-44	172.00
IUUC-Dre-028644	Danio rerio	62.50	3.00e-134	471.00
IUUC-Dno-028925	Dasypus novemcinctus	92.05	0.00e+00	681.00
IUUC-Dor-030692	Dipodomys ordii	92.33	0.00e+00	644.00
IUUC-Dme-031761	Drosophila melanogaster	30.72	4.00e-33	135.00
IUUC-Ete-032329	Echinops telfairi	82.39	8.00e-156	543.00
IUUC-Eca-034008	Equus caballus	89.77	0.00e+00	668.00
IUUC-Eeu-034895	Erinaceus europaeus	75.96	1.00e-121	429.00
IUUC-Fca-036104	Felis catus	93.75	0.00e+00	668.00
IUUC-Fal-036900	Ficedula albicollis	73.76	6.00e-140	490.00
IUUC-Gmo-039049	Gadus morhua	59.09	3.00e-107	381.00
IUUC-Gga-040254	Gallus gallus	71.88	5.00e-147	513.00
IUUC-Gac-042277	Gasterosteus aculeatus	60.23	5.00e-134	470.00
IUUC-Gma-043979	Glycine max	27.19	1.00e-20	94.00
IUUC-Ggo-045509	Gorilla gorilla	100.00	0.00e+00	728.00
IUUC-Hvu-047335	Hordeum vulgare	25.36	5.00e-18	84.70
IUUC-Itr-048691	Ictidomys tridecemlineatus	94.03	0.00e+00	655.00
IUUC-Lch-050344	Latimeria chalumnae	69.03	3.00e-147	514.00
IUUC-Lpe-051343	Leersia perrieri	28.19	3.00e-14	72.40
IUUC-Loc-052376	Lepisosteus oculatus	67.33	3.00e-150	524.00
IUUC-Laf-054414	Loxodonta africana	94.32	0.00e+00	691.00
IUUC-Mcc-054604	Macaca mulatta	99.72	0.00e+00	726.00
IUUC-Meu-056087	Macropus eugenii	85.51	4.00e-174	603.00
IUUC-Mtr-057779	Medicago truncatula	27.35	4.00e-20	92.00
IUUC-Mga-060188	Meleagris gallopavo	73.08	2.00e-144	505.00
IUUC-Mmr-060704	Microcebus murinus	96.59	0.00e+00	705.00
IUUC-Mdo-062842	Monodelphis domestica	85.23	9.00e-167	579.00
IUUC-Mmu-064324	Mus musculus	89.77	7.00e-179	619.00
IUUC-Mpu-065940	Mustela putorius furo	90.06	3.00e-180	624.00
IUUC-Mlu-067028	Myotis lucifugus	92.90	0.00e+00	683.00
IUUC-Nle-069254	Nomascus leucogenys	92.09	0.00e+00	667.00
IUUC-Opr-070827	Ochotona princeps	88.07	0.00e+00	652.00
IUUC-Ont-072008	Oreochromis niloticus	62.22	2.00e-138	485.00
IUUC-Oan-072935	Ornithorhynchus anatinus	79.26	1.00e-167	582.00
IUUC-Ocu-074526	Oryctolagus cuniculus	92.61	0.00e+00	639.00
IUUC-Oba-075954	Oryza barthii	28.19	5.00e-14	72.00
IUUC-Obr-076592	Oryza brachyantha	27.25	4.00e-22	98.60
IUUC-Ogl-077732	Oryza glaberrima	27.62	6.00e-22	98.20
IUUC-Ogu-078565	Oryza glumaepatula	28.19	4.00e-14	72.00
IUUC-Oin-080188	Oryza indica	27.62	6.00e-22	98.20
IUUC-Olo-080705	Oryza longistaminata	25.31	7.00e-13	68.90
IUUC-Ome-081154	Oryza meridionalis	27.86	4.00e-14	72.80
IUUC-Oni-082201	Oryza nivara	28.19	5.00e-14	72.00
IUUC-Opu-083497	Oryza punctata	26.36	3.00e-14	72.80
IUUC-Oru-084332	Oryza rufipogon	28.19	5.00e-14	72.00
IUUC-Osa-086059	Oryza sativa	28.19	2.00e-14	73.20
IUUC-Ola-087288	Oryzias latipes	58.24	2.00e-126	445.00
IUUC-Oga-088402	Otolemur garnettii	94.60	0.00e+00	693.00
IUUC-Oar-089851	Ovis aries	91.98	2.00e-88	317.00
IUUC-Ptr-091226	Pan troglodytes	99.72	0.00e+00	726.00
IUUC-Pan-092575	Papio anubis	99.43	0.00e+00	725.00
IUUC-Psi-094062	Pelodiscus sinensis	77.27	1.00e-165	575.00
IUUC-Pma-094501	Petromyzon marinus	35.59	1.00e-44	173.00
IUUC-Ppa-095285	Physcomitrella patens	25.86	5.00e-16	78.60
IUUC-Pfo-096146	Poecilia formosa	56.82	2.00e-121	429.00
IUUC-Pab-098524	Pongo abelii	99.72	0.00e+00	727.00
IUUC-Pop-099864	Populus trichocarpa	27.48	3.00e-19	89.40
IUUC-Pca-100314	Procavia capensis	92.90	0.00e+00	681.00
IUUC-Ppe-101663	Prunus persica	25.45	3.00e-17	82.40
IUUC-Pva-102947	Pteropus vampyrus	92.61	0.00e+00	681.00
IUUC-Rno-105024	Rattus norvegicus	90.06	0.00e+00	631.00
IUUC-Sha-107500	Sarcophilus harrisii	67.89	2.00e-125	441.00
IUUC-Smo-109194	Selaginella moellendorffii	26.99	1.00e-19	90.50
IUUC-Sit-109922	Setaria italica	26.02	4.00e-21	95.50
IUUC-Sly-111826	Solanum lycopersicum	26.65	4.00e-20	92.40
IUUC-Stu-112907	Solanum tuberosum	26.27	3.00e-19	89.40
IUUC-Sar-113522	Sorex araneus	90.71	2.00e-168	585.00
IUUC-Sbi-114536	Sorghum bicolor	27.62	5.00e-23	102.00
IUUC-Ssc-115445	Sus scrofa	94.32	0.00e+00	646.00
IUUC-Tgu-116551	Taeniopygia guttata	72.73	6.00e-137	480.00
IUUC-Tru-118407	Takifugu rubripes	57.10	6.00e-116	410.00
IUUC-Tsy-118794	Tarsius syrichta	91.76	0.00e+00	671.00
IUUC-Tni-120128	Tetraodon nigroviridis	65.25	4.00e-94	337.00
IUUC-Tca-121508	Theobroma cacao	27.67	8.00e-22	97.80
IUUC-Tae-125185	Triticum aestivum	25.94	1.00e-21	97.40
IUUC-Tur-126470	Triticum urartu	25.65	1.00e-21	97.10
IUUC-Tbe-127432	Tupaia belangeri	95.74	0.00e+00	648.00
IUUC-Ttr-128573	Tursiops truncatus	90.34	0.00e+00	650.00
IUUC-Vpa-130583	Vicugna pacos	92.95	7.00e-177	612.00
IUUC-Vvi-131710	Vitis vinifera	26.57	3.00e-17	82.80
IUUC-Xtr-132009	Xenopus tropicalis	61.58	1.00e-135	475.00
IUUC-Xma-134121	Xiphophorus maculatus	57.79	1.00e-126	446.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence