iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091479

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AACZ03148525

Gene Name

USP51

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000021952.3	ENSPTRT00000040830.3	ENSPTRP00000037727.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.90e-90	302.9	364	706

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L++ip l++++l+ +k+k+  +   +p+ +l++++ +lf+++++++++   p +ll+ ++  ae++ gy+qq
   Q: 364  GLINLGNTCFMNCIVQALTHIPLLKDFFLS-DKHKCIMT---SPSLCLVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQ 448
           9*****************************.99999875...78********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl  +ld l+++ k                  s  +e ++++  +++i+++F g l+s+++c++c++vs++ +p +d+sl++pg+
   Q: 449  DAHEFLIAILDVLHRHSKD----------------DSGGQEANNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGS 521
           *****************22................1223456899******************************************99 PP
   S: 180  eetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
             t  +                    sl+dcL+ ft++e+l ++ k++c++c+++qe++k+l++kklP v ++hLkRf  ++ +k+r+k
   Q: 522  CATFDSqnperadsavsrddhipgipSLTDCLQWFTRPEHLGSSAKIKCNSCQSYQESTKQLTMKKLPIVACFHLKRF--EHVGKQRRK 608
           98776689999*******************************************************************..88889**** PP
   S: 249  inkkvefpleLdlspfctspeekqke...........kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleet 326
           in+ ++fpleLd++pf++s++e+  +           ++kY+L+av++H+G+l+sGHY+++++++k++W+ +dD  +t+ + e+ l   
   Q: 609  INTFISFPLELDMTPFLASTKESRMKegqpptdcvpnENKYSLFAVINHHGTLESGHYTSFIRQQKDQWFSCDDAIITKATIEDLLY-- 695
           *****************99665555578888888888**************************************************.. PP
   S: 327  gstaYvlfYkrr 338
            s++Y+lfY+++
   Q: 696  -SEGYLLFYHKQ 706
           .********985 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MAQVRETSLP SGSGVRWISG GGGGASPEEA VEKAGKMEEA VAGATKASSR REAEEMKLEP 60
LQEREPAPEE NLTWSSSGGD EKVLPSIPLR CHTSSSPVCP RRKPRPRPQP RARSRSQPGL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTGGCATGA TCTGATCGCC TTTAAAGCAG GTAACCGCCT CGGTCTCCCC ATCAGCTCCA 60
GGGGCCTCTC AGTTGAGTGG GTGGAGCCGA CAGAAGCCGC GGGCTGAGCT CAAGGGCCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR033383--USP51
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016578--P:histone deubiquitination
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ptr:107966380; ptr:465660

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001480	Ailuropoda melanoleuca	93.36	0.00e+00	992.00
IUUC-Cja-019402	Callithrix jacchus	97.18	0.00e+00	759.00
IUUC-Csa-023824	Chlorocebus sabaeus	98.48	0.00e+00	1045.00
IUUC-Eca-033872	Equus caballus	94.13	0.00e+00	1001.00
IUUC-Fca-035534	Felis catus	93.83	0.00e+00	1012.00
IUUC-Gma-043933	Glycine max	35.74	5.00e-87	315.00
IUUC-Ggo-045109	Gorilla gorilla	96.93	0.00e+00	1013.00
IUUC-Hsa-045765	Homo sapiens	99.58	0.00e+00	1153.00
IUUC-Itr-048281	Ictidomys tridecemlineatus	94.89	0.00e+00	953.00
IUUC-Mcc-055420	Macaca mulatta	98.35	0.00e+00	1083.00
IUUC-Mmr-061690	Microcebus murinus	94.93	0.00e+00	1035.00
IUUC-Mmu-063435	Mus musculus	80.23	0.00e+00	829.00
IUUC-Mac-065419	Musa acuminata	34.07	2.00e-74	273.00
IUUC-Mpu-065679	Mustela putorius furo	94.12	0.00e+00	984.00
IUUC-Mlu-067084	Myotis lucifugus	92.74	0.00e+00	1010.00
IUUC-Nle-069859	Nomascus leucogenys	99.02	0.00e+00	1138.00
IUUC-Ocu-074365	Oryctolagus cuniculus	93.02	0.00e+00	972.00
IUUC-Pan-091707	Papio anubis	98.29	0.00e+00	1042.00
IUUC-Pab-097894	Pongo abelii	99.62	0.00e+00	1068.00
IUUC-Pop-099893	Populus trichocarpa	36.80	2.00e-82	299.00
IUUC-Ppe-101583	Prunus persica	36.72	1.00e-78	287.00
IUUC-Rno-105644	Rattus norvegicus	79.42	0.00e+00	838.00
IUUC-Sar-113426	Sorex araneus	80.00	0.00e+00	832.00
IUUC-Sre-115195	Sporisorium reilianum	26.59	4.00e-49	189.00
IUUC-Ssc-115500	Sus scrofa	91.30	0.00e+00	979.00
IUUC-Tsy-119413	Tarsius syrichta	92.74	0.00e+00	1003.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence