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Tag Content
UUCD2 ID IUUC-Dre-028694
UUCD1 version UUC-DaR-01234
Ensembl Protein ID ENSDARP00000121765.1
UniProt Accession Q6NYM1; KLH21_DANRE
Genbank Protein ID AAH66537.1; AAI55819.1
Protein Name Kelch-like protein 21
Genbank Nucleotide ID BC066537; BC155818
Gene Name klhl21; zgc:76933
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000039255.5 ENSDART00000137486.2 ENSDARP00000121765.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 2.50e-18 67.1 39 103
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 1.30e-09 37.3 137 167
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 2    DvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           Dv+l+ +g+ef++h+ vLaa+S +F+a+f + l+es   ++v++++v++e +  l++F+Ytg+++ 
   Q: 39   DVTLCAEGKEFHCHRTVLAAASMYFRAMFAGTLRESV-MDRVVLHEVSAELLGLLVDFCYTGRVTV 103
           9***********************************9.*************************975 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           ++Ncl+i +fA++y c++L+ +a++f+lk+ 
   Q: 137  VSNCLEIQDFAEAYACRELAASARRFVLKNI 167
           69***************************95 PP
   
Organism Danio rerio
Functional Description
(View)

Functional Description


     Substrate-specific adapter of BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (By similarity).
 Substrate-specific adapter of BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (By similarity).
Protein Sequence
(Fasta)
MEKPVLQTQP SMLPFFDTAH AVNLLRGIHE LRAERKFFDV TLCAEGKEFH CHRTVLAAAS 60
MYFRAMFAGT LRESVMDRVV LHEVSAELLG LLVDFCYTGR VTVTHDNVDL LLKTADLFQF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dre-028694|E3,BTB_3-box|Danio rerio
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Nucleotide Sequence
(Fasta)
GAGCGAGCCC AAAACCGACA TGCTAGCAAA TTTAAACCAT ACATACACAA ATTAATCCAA 60
TCTGCCGAAC TATCCGAGGC GAATATTAAC AGAAACAGTC AACGGCTGGC TTCGGTAAGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dre-028694|E3,BTB_3-box|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0880--Kelch repeat
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005827--C:polar microtubule
GO:0051301--P:cell division
GO:0035853--P:chromosome passenger complex localization to spindle midzone
GO:0007067--P:mitotic nuclear division
GO:0016567--P:protein ubiquitination
GO:0032465--P:regulation of cytokinesis
KEGG dre:404613
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001782 Ailuropoda melanoleuca 68.23 0.00e+00 702.00
IUUC-Apl-003189 Anas platyrhynchos 75.81 2.00e-129 454.00
IUUC-Ame-011774 Astyanax mexicanus 93.24 0.00e+00 680.00
IUUC-Bta-012367 Bos taurus 72.01 0.00e+00 842.00
IUUC-Cja-019501 Callithrix jacchus 66.14 0.00e+00 763.00
IUUC-Cfa-020550 Canis familiaris 71.68 0.00e+00 843.00
IUUC-Cpo-022072 Cavia porcellus 72.01 0.00e+00 825.00
IUUC-Csa-023364 Chlorocebus sabaeus 73.71 0.00e+00 773.00
IUUC-Cin-025253 Ciona intestinalis 45.27 2.00e-153 535.00
IUUC-Csv-025871 Ciona savignyi 45.10 8.00e-157 547.00
IUUC-Dno-029082 Dasypus novemcinctus 73.79 0.00e+00 733.00
IUUC-Dor-030680 Dipodomys ordii 71.48 0.00e+00 835.00
IUUC-Ete-032315 Echinops telfairi 74.06 0.00e+00 741.00
IUUC-Eca-033570 Equus caballus 76.83 6.00e-159 553.00
IUUC-Eeu-035067 Erinaceus europaeus 80.72 2.00e-112 399.00
IUUC-Fal-037103 Ficedula albicollis 69.63 0.00e+00 766.00
IUUC-Gmo-039420 Gadus morhua 86.22 0.00e+00 1085.00
IUUC-Gga-040161 Gallus gallus 68.63 0.00e+00 750.00
IUUC-Gac-041755 Gasterosteus aculeatus 87.93 0.00e+00 1084.00
IUUC-Ggo-044899 Gorilla gorilla 71.83 0.00e+00 842.00
IUUC-Hsa-045834 Homo sapiens 71.83 0.00e+00 842.00
IUUC-Itr-048413 Ictidomys tridecemlineatus 72.01 0.00e+00 841.00
IUUC-Lch-050338 Latimeria chalumnae 77.46 0.00e+00 982.00
IUUC-Loc-051780 Lepisosteus oculatus 87.29 0.00e+00 1075.00
IUUC-Laf-053725 Loxodonta africana 77.58 0.00e+00 634.00
IUUC-Mcc-055032 Macaca mulatta 70.83 0.00e+00 728.00
IUUC-Meu-056661 Macropus eugenii 80.16 0.00e+00 653.00
IUUC-Mga-059821 Meleagris gallopavo 74.80 4.00e-114 404.00
IUUC-Mdo-062095 Monodelphis domestica 71.76 0.00e+00 744.00
IUUC-Mmu-063138 Mus musculus 72.36 0.00e+00 846.00
IUUC-Mpu-066386 Mustela putorius furo 83.85 2.00e-151 528.00
IUUC-Mlu-067807 Myotis lucifugus 81.99 2.00e-161 561.00
IUUC-Nle-069181 Nomascus leucogenys 71.13 0.00e+00 828.00
IUUC-Opr-070658 Ochotona princeps 72.89 0.00e+00 858.00
IUUC-Ont-072209 Oreochromis niloticus 90.39 0.00e+00 1110.00
IUUC-Ocu-074631 Oryctolagus cuniculus 65.85 0.00e+00 739.00
IUUC-Ola-087553 Oryzias latipes 86.92 0.00e+00 1068.00
IUUC-Oga-088782 Otolemur garnettii 72.01 0.00e+00 841.00
IUUC-Oar-089634 Ovis aries 71.48 0.00e+00 838.00
IUUC-Ptr-091259 Pan troglodytes 75.79 0.00e+00 655.00
IUUC-Pan-091734 Papio anubis 72.01 0.00e+00 844.00
IUUC-Psi-092979 Pelodiscus sinensis 69.84 0.00e+00 789.00
IUUC-Pma-094459 Petromyzon marinus 49.59 9.00e-118 417.00
IUUC-Pfo-097446 Poecilia formosa 89.85 0.00e+00 1102.00
IUUC-Pab-098765 Pongo abelii 70.17 0.00e+00 845.00
IUUC-Pva-102730 Pteropus vampyrus 68.31 0.00e+00 791.00
IUUC-Rno-104972 Rattus norvegicus 69.93 0.00e+00 850.00
IUUC-Ssc-115869 Sus scrofa 70.61 0.00e+00 731.00
IUUC-Tgu-116562 Taeniopygia guttata 69.89 0.00e+00 785.00
IUUC-Tru-118490 Takifugu rubripes 88.34 0.00e+00 1094.00
IUUC-Tni-119898 Tetraodon nigroviridis 85.42 0.00e+00 1050.00
IUUC-Ttr-128976 Tursiops truncatus 80.27 2.00e-111 396.00
IUUC-Xtr-132876 Xenopus tropicalis 75.80 0.00e+00 919.00
IUUC-Xma-133540 Xiphophorus maculatus 89.02 0.00e+00 1102.00
Created Date 25-Jun-2017

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