iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/CUE	CUE	17347654

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/CUE	2.20e-06	29.2	146	187

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 3    etaleqLkeiFPnldysviqvvLeantgsleaavnnLLegse 44
            + ++ L e+FP++++++ q+vL   +g+le+av++L eg+e
   Q: 146  LPGVDVLLEVFPTCSVEQAQWVLAKARGDLEEAVQMLVEGKE 187
           56778999*******************************985 PP

Organism

Homo sapiens

Functional Description
(View)

Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.

Protein Sequence
(Fasta)

MELERIVSAA LLAFVQTHLP EADLSGLDEV IFSYVLGVLE DLGPSGPSEE NFDMEAFTEM 60
MEAYVPGFAH IPRGTIGDMM QKLSGQLSDA RNKENLQPQS SGVQGQVPIS PEPLQRPEML 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCCTTCTCA AACATGGCCG CCACGGCGCC TCTGGAAGGG AACCGCTCTG GGCCCCGCCT 60
TTGATCTCGT TGGTGGGGCT GGGGGATGAG AGCTGCACCG CGCGGGACAA GTCGCCGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR003892--CUE

PROSITE

PS51140--CUE

Pfam

PF02845--CUE

Gene Ontology

GO:0005829--C:cytosol
GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:1900016--P:negative regulation of cytokine production involved in inflammatory response
GO:0010936--P:negative regulation of macrophage cytokine production

KEGG

hsa:79004

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001790	Ailuropoda melanoleuca	96.17	4.00e-156	543.00
IUUC-Apl-003944	Anas platyrhynchos	54.67	7.00e-74	270.00
IUUC-Acl-008346	Aspergillus clavatus	36.11	4.70e+00	27.30
IUUC-Ang-009821	Aspergillus niger	42.11	5.00e-03	36.20
IUUC-Ame-011202	Astyanax mexicanus	46.58	2.00e-70	258.00
IUUC-Bta-012549	Bos taurus	71.70	4.00e-121	427.00
IUUC-Cja-019719	Callithrix jacchus	91.67	2.00e-147	514.00
IUUC-Cfa-021223	Canis familiaris	95.12	4.00e-159	553.00
IUUC-Cpo-021485	Cavia porcellus	88.50	1.00e-145	508.00
IUUC-Cre-022630	Chlamydomonas reinhardtii	63.64	2.20e-01	30.80
IUUC-Csa-023808	Chlorocebus sabaeus	98.95	8.00e-153	532.00
IUUC-Cne-026987	Cryptococcus neoformans	34.29	4.20e+00	27.30
IUUC-Dre-027377	Danio rerio	43.34	1.00e-55	209.00
IUUC-Dno-029148	Dasypus novemcinctus	92.68	4.00e-156	543.00
IUUC-Dor-030884	Dipodomys ordii	90.08	5.00e-128	449.00
IUUC-Dme-031833	Drosophila melanogaster	31.25	2.00e-17	83.20
IUUC-Eca-033224	Equus caballus	95.47	6.00e-160	556.00
IUUC-Fca-036557	Felis catus	94.77	4.00e-156	543.00
IUUC-Fal-036631	Ficedula albicollis	53.92	3.00e-78	284.00
IUUC-Fso-038371	Fusarium solani	35.14	4.70e+00	27.30
IUUC-Gmo-038930	Gadus morhua	44.90	5.00e-63	234.00
IUUC-Gga-041066	Gallus gallus	55.82	8.00e-81	293.00
IUUC-Gac-041736	Gasterosteus aculeatus	43.69	2.00e-66	246.00
IUUC-Ggo-045551	Gorilla gorilla	99.65	2.00e-152	531.00
IUUC-Itr-047925	Ictidomys tridecemlineatus	92.33	7.00e-155	539.00
IUUC-Lch-049728	Latimeria chalumnae	58.87	5.00e-45	173.00
IUUC-Loc-052375	Lepisosteus oculatus	47.97	1.00e-63	236.00
IUUC-Laf-054367	Loxodonta africana	89.90	7.00e-148	516.00
IUUC-Mcc-055535	Macaca mulatta	94.46	1.00e-151	528.00
IUUC-Meu-056716	Macropus eugenii	57.99	2.00e-88	318.00
IUUC-Mla-059087	Melampsora laricipopulina	39.13	1.30e-02	32.30
IUUC-Mga-059259	Meleagris gallopavo	55.63	3.00e-80	291.00
IUUC-Mdo-062874	Monodelphis domestica	59.26	5.00e-63	234.00
IUUC-Mmu-063091	Mus musculus	87.11	6.00e-143	499.00
IUUC-Mpu-066538	Mustela putorius furo	94.77	2.00e-156	545.00
IUUC-Mlu-068118	Myotis lucifugus	93.73	8.00e-150	522.00
IUUC-Nle-069262	Nomascus leucogenys	100.00	5.00e-154	536.00
IUUC-Opr-070887	Ochotona princeps	89.90	8.00e-145	506.00
IUUC-Ont-072566	Oreochromis niloticus	43.88	8.00e-65	240.00
IUUC-Oan-073555	Ornithorhynchus anatinus	58.13	4.00e-86	311.00
IUUC-Ocu-073954	Oryctolagus cuniculus	93.75	1.00e-156	545.00
IUUC-Ola-087131	Oryzias latipes	42.12	2.00e-59	222.00
IUUC-Oga-088232	Otolemur garnettii	89.55	8.00e-130	456.00
IUUC-Oar-090288	Ovis aries	87.46	8.00e-141	492.00
IUUC-Ptr-091641	Pan troglodytes	100.00	5.00e-154	536.00
IUUC-Pan-092307	Papio anubis	96.94	3.00e-163	567.00
IUUC-Psi-093174	Pelodiscus sinensis	50.51	8.00e-58	217.00
IUUC-Pfo-096255	Poecilia formosa	45.21	8.00e-68	250.00
IUUC-Pab-098066	Pongo abelii	98.28	3.00e-163	567.00
IUUC-Pca-101113	Procavia capensis	87.80	9.00e-139	486.00
IUUC-Pva-102662	Pteropus vampyrus	91.29	2.00e-143	501.00
IUUC-Rno-105183	Rattus norvegicus	81.53	2.00e-119	421.00
IUUC-Sha-107507	Sarcophilus harrisii	62.59	3.00e-99	354.00
IUUC-Spo-108252	Schizosaccharomyces pombe	24.54	1.70e-01	31.20
IUUC-Sre-115033	Sporisorium reilianum	25.33	1.20e+00	29.30
IUUC-Ssc-115243	Sus scrofa	71.29	2.00e-66	247.00
IUUC-Tgu-117106	Taeniopygia guttata	53.63	7.00e-75	273.00
IUUC-Tru-117992	Takifugu rubripes	43.69	4.00e-64	238.00
IUUC-Tni-120145	Tetraodon nigroviridis	44.75	4.00e-67	248.00
IUUC-Tbe-127268	Tupaia belangeri	94.14	5.00e-119	419.00
IUUC-Uma-129410	Ustilago maydis	37.84	3.80e-01	30.80
IUUC-Xtr-132299	Xenopus tropicalis	50.17	5.00e-78	283.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence