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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045962
UUCD1 version UUC-HoS-00457
Ensembl Protein ID ENSP00000359206.3
UniProt Accession Q9Y297; B5MD49; Q5W141; Q5W142; Q9Y213; FBW1A_HUMAN
Genbank Protein ID AAD08702.1; CAA74572.1; AAF04464.1; ADU87633.1; BAG36155.1; CAH70019.1; CAH70019.1; CAH70019.1; CAH70020.1; CAH70020.1; CAH70020.1; CAI12963.1; CAI12963.1; CAI12963.1; CAI12964.1; CAI12964.1; CAI12964.1; CAI41042.1; CAI41042.1; CAI41042.1; CAI41043.1; CAI41043.1; CAI41043.1; EAW49772.1; EAW49774.1; AAH27994.1
Protein Name F-box/WD repeat-containing protein 1A; E3RSIkappaB; Epididymis tissue protein Li 2a; F-box and WD repeats protein beta-TrCP; pIkappaBalpha-E3 receptor subunit
Genbank Nucleotide ID AF101784; Y14153; AF129530; GU727631; AK313353; AL133387; AL445463; AL627424; AL133387; AL445463; AL627424; AL445463; AL133387; AL627424; AL445463; AL133387; AL627424; AL627424; AL133387; AL445463; AL627424; AL133387; AL445463; CH471066; CH471066; BC027994
Gene Name BTRC; BTRCP; FBW1A; FBXW1A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000166167.17 ENST00000370187.7 ENSP00000359206.3
ENSG00000166167.17 ENST00000408038.6 ENSP00000385339.2
ENSG00000166167.17 ENST00000393441.8 ENSP00000377088.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanmiRecordsRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 18166147; 18378670; 18460583; 18500245; 10074433; 18650423; 18354483; 19004823; 19631635; 19478868; 19297328; 15082796; 19276348; 19270156; 19244340; 17965458; 10437795; 19211746; 19196987; 17217622; 14525958; 14988407; 20068069; 19929170; 16303288; 21173164; 18575781; 19797085; 16219772; 21402774; 21068446; 17445772
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 18166147; 18460583; 18500245; 10074433; 18650423; 19004823; 19631635; 19557001; 19478868; 19297328; 19276348; 17965458; 10437795; 19196987; 17217622; 19929170; 16303288; 21173164; 19797085; 16219772
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 0.00097 20.9 191 228
E3 adaptor/Cullin RING/DCX/DWD 1.60e-58 193.6 504 539
UBD/Beta-Prp 2.20e-68 232.3 418 582
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 109  eilveilklldkeellraarvcrrwqelasqkalwktv 146
           +i  +il++ld+++l++a++vc++w++++s+  lwk++
   Q: 191  HIAENILSYLDAKSLCAAELVCKEWYRVTSDGMLWKKL 228
           7899**************************9****987 PP
   

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvll 36
           gH++ v+c++f d +++vsG++Dg+ikvWDl    ++
   Q: 504  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLVAALDP 539
           8**********.44****************9876665 PP
   

   UBD/Beta-Prp
   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsg 135
           l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ +l+g
   Q: 418  LRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR-VLEG 504
           445569*************9..8**************************************..************************.**** PP
   S: 136  hdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           h+++v+c++++   + +vsG++D+++++Wdl         +   +lrtl + h ++v  l+fd+  +++vs s+d t+ +wd+
   Q: 505  HEELVRCIRFDN--KRIVSGAYDGKIKVWDLvaaldprapAGTLCLRTLVE-HSGRVFRLQFDE--FQIVSSSHDDTILIWDF 582
           ***********9..*************************877889****98.************..99**************7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25704143, PubMed:25503564). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3.
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25704143, PubMed:25503564). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3.
Protein Sequence
(Fasta)
MDPAEAVLQE KALKFMCSMP RSLWLGCSSL ADSMPSLRCL YNPGTGALTA FQNSSEREDC 60
NNGEPPRKII PEKNSLRQTY NSCARLCLNQ ETVCLASTAM KTENCVAKTK LANGTSSMIV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045962|E3,F-box;E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GATTCTCCTT GGCCCCTCAG CCTGCGCCTG AGAGGTAAGA GAGGGCGGGG GGAAGGAAGA 60
GGAGGCGGGA TCCGGGCGCT GCGTTGGCTG CGGCCTGGCA CCAAAGGGGC GGCCCCGGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045962|E3,F-box;E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0945--Host-virus interaction
KW-0436--Ligase
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
KW-0879--Wnt signaling pathway
Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0008013--F:beta-catenin binding
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0060444--P:branching involved in mammary gland duct morphogenesis
GO:0071407--P:cellular response to organic cyclic compound
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0033598--P:mammary gland epithelial cell proliferation
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045879--P:negative regulation of smoothened signaling pathway
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0038061--P:NIK/NF-kappaB signaling
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0060828--P:regulation of canonical Wnt signaling pathway
GO:0042752--P:regulation of circadian rhythm
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0048511--P:rhythmic process
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0007165--P:signal transduction
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0051403--P:stress-activated MAPK cascade
GO:0050852--P:T cell receptor signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0016032--P:viral process
GO:0016055--P:Wnt signaling pathway
KEGG hsa:8945
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001961 Ailuropoda melanoleuca 99.67 0.00e+00 1260.00
IUUC-Apl-003437 Anas platyrhynchos 98.60 0.00e+00 1024.00
IUUC-Aca-004410 Anolis carolinensis 92.83 0.00e+00 1209.00
IUUC-Acl-008355 Aspergillus clavatus 29.69 3.00e-51 196.00
IUUC-Afl-008580 Aspergillus flavus 27.46 2.00e-44 174.00
IUUC-Afu-008790 Aspergillus fumigatus 30.02 6.00e-49 189.00
IUUC-Ani-009324 Aspergillus nidulans 29.40 1.00e-48 187.00
IUUC-Aor-010185 Aspergillus oryzae 29.58 2.00e-51 197.00
IUUC-Ate-010492 Aspergillus terreus 30.18 2.00e-50 193.00
IUUC-Bgr-012194 Blumeria graminis 32.52 3.00e-54 206.00
IUUC-Bta-013453 Bos taurus 93.72 0.00e+00 1166.00
IUUC-Bci-013685 Botrytis cinerea 31.58 5.00e-55 209.00
IUUC-Cel-018392 Caenorhabditis elegans 63.71 0.00e+00 635.00
IUUC-Cja-019121 Callithrix jacchus 95.37 0.00e+00 1190.00
IUUC-Cfa-020553 Canis familiaris 99.83 0.00e+00 1261.00
IUUC-Cpo-022126 Cavia porcellus 97.14 0.00e+00 1169.00
IUUC-Csa-023688 Chlorocebus sabaeus 100.00 0.00e+00 1263.00
IUUC-Cin-025188 Ciona intestinalis 80.50 0.00e+00 827.00
IUUC-Csv-026020 Ciona savignyi 76.54 0.00e+00 790.00
IUUC-Cgl-026429 Colletotrichum gloeosporioides 33.55 3.00e-61 229.00
IUUC-Dno-029484 Dasypus novemcinctus 93.55 0.00e+00 1167.00
IUUC-Dor-031010 Dipodomys ordii 92.70 0.00e+00 1099.00
IUUC-Dse-031287 Dothistroma septosporum 29.34 5.00e-53 202.00
IUUC-Dme-031885 Drosophila melanogaster 80.41 0.00e+00 819.00
IUUC-Ete-032978 Echinops telfairi 86.72 0.00e+00 1055.00
IUUC-Eca-033374 Equus caballus 98.82 0.00e+00 1224.00
IUUC-Eeu-034760 Erinaceus europaeus 78.35 0.00e+00 946.00
IUUC-Fca-035427 Felis catus 95.54 0.00e+00 1192.00
IUUC-Fal-037530 Ficedula albicollis 98.64 0.00e+00 1212.00
IUUC-Fox-037978 Fusarium oxysporum 33.55 2.00e-62 234.00
IUUC-Fso-038077 Fusarium solani 32.75 3.00e-57 216.00
IUUC-Ggr-039974 Gaeumannomyces graminis 32.08 4.00e-56 213.00
IUUC-Gga-041087 Gallus gallus 95.06 0.00e+00 1232.00
IUUC-Ggo-045369 Gorilla gorilla 99.64 0.00e+00 1152.00
IUUC-Itr-047872 Ictidomys tridecemlineatus 99.56 0.00e+00 941.00
IUUC-Lch-050285 Latimeria chalumnae 90.18 0.00e+00 945.00
IUUC-Loc-052686 Lepisosteus oculatus 92.56 0.00e+00 1171.00
IUUC-Lma-053289 Leptosphaeria maculans 38.43 8.00e-48 185.00
IUUC-Laf-054022 Loxodonta africana 98.82 0.00e+00 1224.00
IUUC-Mcc-055782 Macaca mulatta 100.00 0.00e+00 1226.00
IUUC-Meu-056078 Macropus eugenii 84.60 0.00e+00 900.00
IUUC-Mor-057283 Magnaporthe oryzae 33.26 6.00e-59 222.00
IUUC-Mpo-057540 Magnaporthe poae 32.30 9.00e-57 215.00
IUUC-Mla-058989 Melampsora laricipopulina 40.88 4.00e-61 228.00
IUUC-Mga-059388 Meleagris gallopavo 97.33 0.00e+00 1217.00
IUUC-Mmr-060969 Microcebus murinus 99.83 0.00e+00 1261.00
IUUC-Mdo-063041 Monodelphis domestica 99.34 0.00e+00 1224.00
IUUC-Mmu-064096 Mus musculus 98.68 0.00e+00 1249.00
IUUC-Mpu-066875 Mustela putorius furo 99.64 0.00e+00 1149.00
IUUC-Mlu-067621 Myotis lucifugus 99.01 0.00e+00 1036.00
IUUC-Nfi-068263 Neosartorya fischeri 29.50 2.00e-50 193.00
IUUC-Ncr-068639 Neurospora crassa 34.82 3.00e-45 177.00
IUUC-Nle-069548 Nomascus leucogenys 99.83 0.00e+00 1261.00
IUUC-Opr-071194 Ochotona princeps 93.72 0.00e+00 1166.00
IUUC-Oan-072867 Ornithorhynchus anatinus 95.67 0.00e+00 1233.00
IUUC-Ocu-074246 Oryctolagus cuniculus 99.83 0.00e+00 1261.00
IUUC-Oga-088244 Otolemur garnettii 99.60 0.00e+00 1037.00
IUUC-Oar-089199 Ovis aries 99.02 0.00e+00 1047.00
IUUC-Ptr-090475 Pan troglodytes 79.70 0.00e+00 939.00
IUUC-Pan-092826 Papio anubis 100.00 0.00e+00 1263.00
IUUC-Psi-093485 Pelodiscus sinensis 95.96 0.00e+00 1182.00
IUUC-Pma-094315 Petromyzon marinus 80.79 0.00e+00 894.00
IUUC-Pab-097680 Pongo abelii 99.50 0.00e+00 1257.00
IUUC-Pca-100843 Procavia capensis 92.73 0.00e+00 1136.00
IUUC-Pva-102793 Pteropus vampyrus 89.42 0.00e+00 1096.00
IUUC-Pgr-103331 Puccinia graminis 37.69 3.00e-52 199.00
IUUC-Ptt-103853 Puccinia triticina 32.08 6.00e-61 228.00
IUUC-Pte-104392 Pyrenophora teres 37.37 9.00e-48 185.00
IUUC-Pyt-104678 Pyrenophora triticirepentis 37.72 5.00e-48 186.00
IUUC-Rno-105304 Rattus norvegicus 98.47 0.00e+00 1211.00
IUUC-Sha-107454 Sarcophilus harrisii 94.79 0.00e+00 1207.00
IUUC-Spo-108200 Schizosaccharomyces pombe 32.08 1.00e-66 247.00
IUUC-Sar-113471 Sorex araneus 78.18 0.00e+00 926.00
IUUC-Sre-114916 Sporisorium reilianum 33.71 8.00e-46 179.00
IUUC-Ssc-115490 Sus scrofa 99.60 0.00e+00 1054.00
IUUC-Tgu-117445 Taeniopygia guttata 98.51 0.00e+00 1244.00
IUUC-Tsy-118983 Tarsius syrichta 95.25 0.00e+00 1164.00
IUUC-Tre-122207 Trichoderma reesei 33.63 8.00e-56 211.00
IUUC-Tvi-122344 Trichoderma virens 34.00 7.00e-56 212.00
IUUC-Tme-127141 Tuber melanosporum 35.86 2.00e-64 240.00
IUUC-Tbe-128146 Tupaia belangeri 89.92 0.00e+00 1070.00
IUUC-Ttr-128946 Tursiops truncatus 99.67 0.00e+00 1260.00
IUUC-Uma-129491 Ustilago maydis 33.42 7.00e-47 182.00
IUUC-Vda-129941 Verticillium dahliae 32.23 2.00e-57 217.00
IUUC-Vpa-130709 Vicugna pacos 97.85 0.00e+00 1228.00
IUUC-Xtr-132861 Xenopus tropicalis 92.54 0.00e+00 1167.00
Created Date 25-Jun-2017

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