iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067829

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02032227

Gene Name

SOCS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000000674.2	ENSMLUT00000000669.2	ENSMLUP00000000610.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	4.10e-13	49.0	162	209

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            ++l+++++r+Lq+LCR +I+ ++g+++l    ++PL+++L+dYL+++++q
   Q: 162  GAPLRQRRVRPLQELCRQRIVATVGRENL---GRIPLNPVLRDYLSSFPFQ 209
           6789*************************...***************9986 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MVAHNQVAAD NAISAAAEPR RRPEPSSSSS TPAALVRPRP CPAVPTPAPG DTHFRTFRSH 60
ADYRRITHTS ALLDACGFYW GPLSVHGAHE RLRAEPVGTF LVRDSRQRNC FFALSVKMSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTAGCAC ACAACCAGGT GGCAGCCGAC AATGCAATCT CCGCGGCAGC AGAGCCCCGA 60
CGGCGGCCCG AGCCTTCCTC CTCTTCCTCC ACGCCCGCGG CCCTGGTGCG CCCGCGGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028411--SOCS1
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0000932--C:P-body
GO:0019210--F:kinase inhibitor activity
GO:0071230--P:cellular response to amino acid stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0045444--P:fat cell differentiation
GO:0007259--P:JAK-STAT cascade
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0016567--P:protein ubiquitination
GO:0010534--P:regulation of activation of JAK2 kinase activity
GO:0050707--P:regulation of cytokine secretion
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001204	Ailuropoda melanoleuca	86.75	1.00e-77	282.00
IUUC-Apl-003313	Anas platyrhynchos	69.94	2.00e-70	258.00
IUUC-Aca-005109	Anolis carolinensis	67.09	9.00e-62	229.00
IUUC-Ame-011550	Astyanax mexicanus	51.25	2.00e-49	188.00
IUUC-Bta-013411	Bos taurus	96.89	8.00e-90	322.00
IUUC-Cja-019595	Callithrix jacchus	97.53	5.00e-91	326.00
IUUC-Cfa-020563	Canis familiaris	95.03	6.00e-88	316.00
IUUC-Cpo-021374	Cavia porcellus	98.14	6.00e-91	326.00
IUUC-Csa-023333	Chlorocebus sabaeus	96.89	7.00e-90	322.00
IUUC-Dre-028507	Danio rerio	47.44	7.00e-45	173.00
IUUC-Dno-029406	Dasypus novemcinctus	96.27	9.00e-89	318.00
IUUC-Ete-032399	Echinops telfairi	96.27	6.00e-89	319.00
IUUC-Eca-033519	Equus caballus	94.38	4.00e-85	306.00
IUUC-Fal-036726	Ficedula albicollis	70.55	7.00e-72	263.00
IUUC-Gmo-039667	Gadus morhua	49.56	5.00e-26	110.00
IUUC-Gga-040970	Gallus gallus	70.55	3.00e-71	260.00
IUUC-Gac-041838	Gasterosteus aculeatus	43.02	5.00e-36	144.00
IUUC-Ggo-045569	Gorilla gorilla	97.50	5.00e-90	323.00
IUUC-Hsa-046010	Homo sapiens	97.52	3.00e-90	324.00
IUUC-Itr-047995	Ictidomys tridecemlineatus	97.52	5.00e-90	323.00
IUUC-Lch-050219	Latimeria chalumnae	61.49	8.00e-62	229.00
IUUC-Loc-052494	Lepisosteus oculatus	57.86	8.00e-55	206.00
IUUC-Laf-054219	Loxodonta africana	94.85	1.00e-70	258.00
IUUC-Mcc-054830	Macaca mulatta	96.89	8.00e-90	322.00
IUUC-Meu-056565	Macropus eugenii	75.27	1.00e-78	285.00
IUUC-Mga-060153	Meleagris gallopavo	69.57	2.00e-69	254.00
IUUC-Mmr-061365	Microcebus murinus	97.52	3.00e-90	324.00
IUUC-Mdo-062824	Monodelphis domestica	76.57	2.00e-77	281.00
IUUC-Mmu-064120	Mus musculus	96.27	9.00e-90	322.00
IUUC-Mpu-066839	Mustela putorius furo	97.52	3.00e-90	324.00
IUUC-Nle-069592	Nomascus leucogenys	93.79	4.00e-86	310.00
IUUC-Ont-072173	Oreochromis niloticus	45.18	3.00e-38	151.00
IUUC-Oan-073586	Ornithorhynchus anatinus	51.28	4.00e-26	110.00
IUUC-Ocu-073996	Oryctolagus cuniculus	97.52	3.00e-90	323.00
IUUC-Oba-075150	Oryza barthii	30.59	2.50e-02	31.60
IUUC-Ola-087158	Oryzias latipes	46.88	2.00e-39	155.00
IUUC-Oga-088076	Otolemur garnettii	95.29	2.00e-93	334.00
IUUC-Ptr-091241	Pan troglodytes	97.52	2.00e-90	324.00
IUUC-Pan-091836	Papio anubis	96.88	2.00e-89	321.00
IUUC-Psi-093628	Pelodiscus sinensis	73.01	3.00e-72	264.00
IUUC-Pfo-097501	Poecilia formosa	45.91	8.00e-37	146.00
IUUC-Pab-098170	Pongo abelii	97.52	3.00e-90	324.00
IUUC-Pop-100072	Populus trichocarpa	32.69	1.20e-02	33.90
IUUC-Pva-102796	Pteropus vampyrus	96.89	7.00e-90	322.00
IUUC-Rno-105319	Rattus norvegicus	96.27	9.00e-90	322.00
IUUC-Sha-107201	Sarcophilus harrisii	79.87	5.00e-73	266.00
IUUC-Ssc-116004	Sus scrofa	97.52	5.00e-90	323.00
IUUC-Tgu-116836	Taeniopygia guttata	71.17	2.00e-71	261.00
IUUC-Tru-118090	Takifugu rubripes	43.75	4.00e-36	144.00
IUUC-Tni-120719	Tetraodon nigroviridis	44.38	5.00e-32	130.00
IUUC-Vpa-130235	Vicugna pacos	97.52	2.00e-90	324.00
IUUC-Xtr-132610	Xenopus tropicalis	62.01	5.00e-68	249.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence