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Tag Content
iUUCD ID IUUC-Bta-013509
Ensembl Protein ID ENSBTAP00000021459.5
UniProt Accession A7MBI0; A7Z043; PACN1_BOVIN
Genbank Protein ID AAI51573.1; AAI53242.1
Protein Name Protein kinase C and casein kinase substrate in neurons protein 1
Genbank Nucleotide ID BC151572; BC153241
Gene Name PACSIN1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000016124.5 ENSBTAT00000021459.5 ENSBTAP00000021459.5
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 3.20e-15 56.0 389 444
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +v++lydy++q++deL++k+Gd ++ +  ee ++gW++g + ++g+ Gl P+n+ve +
   Q: 389  RVRALYDYDGQEQDELSFKAGDELTKL-GEEDEQGWCRG-RLDSGQLGLYPANYVEVV 444
           699************************.***********.59*************975 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity).
 Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity).
Protein Sequence
(Fasta)
MSGSYDEASL APEETTDSFW EVGNYKRTVK RIDDGHRLCN DLMSCVQERA KIEKAYAQQL 60
TDWAKRWRQL LEKGPQYGSL ERAWGAIMTE ADKVSELHQE MKNSLLNEDL EKVKNWQKDA 120
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Protein Fasta Sequence


>IUUC-Bta-013509|UBD,SH3|Bos taurus
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Nucleotide Sequence
(Fasta)
GTCCGGAGGG ACGCGGCGGC GCAGCCTCTC TTGCCCCCCG GGAAGTCGAT CGGGCTTGAG 60
GCCGGGCCCC CAGACGCCCC GCTTGGCCCC GCGGCGCCGC CGATGGTGCC GGGCGCCCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-013509|UBD,SH3|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0965--Cell junction
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0254--Endocytosis
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0770--Synapse
KW-0771--Synaptosome
Interpro

IPR027267--AH/BAR-dom
IPR031160--F_BAR
IPR001060--FCH_dom
IPR028518--PACSIN1
IPR001452--SH3_domain
PROSITE

PS51741--F_BAR
PS50002--SH3
Pfam

PF00611--FCH
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
SMART

SM00055--FCH
SM00326--SH3
Gene Ontology

GO:0043679--C:axon terminus
GO:0030054--C:cell junction
GO:0030137--C:COPI-coated vesicle
GO:0005737--C:cytoplasm
GO:0030659--C:cytoplasmic vesicle membrane
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0043209--C:myelin sheath
GO:0032587--C:ruffle membrane
GO:0005543--F:phospholipid binding
GO:0007015--P:actin filament organization
GO:0045806--P:negative regulation of endocytosis
GO:0048812--P:neuron projection morphogenesis
GO:0097320--P:plasma membrane tubulation
GO:0072657--P:protein localization to membrane
GO:0030100--P:regulation of endocytosis
GO:0048488--P:synaptic vesicle endocytosis
KEGG bta:520488
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001861 Ailuropoda melanoleuca 86.68 0.00e+00 764.00
IUUC-Apl-003667 Anas platyrhynchos 83.26 0.00e+00 696.00
IUUC-Aca-005229 Anolis carolinensis 80.04 0.00e+00 709.00
IUUC-Ame-011410 Astyanax mexicanus 72.65 3.00e-177 614.00
IUUC-Cja-019659 Callithrix jacchus 94.14 0.00e+00 805.00
IUUC-Cfa-020396 Canis familiaris 95.95 0.00e+00 789.00
IUUC-Cpo-022376 Cavia porcellus 95.27 0.00e+00 784.00
IUUC-Csa-023701 Chlorocebus sabaeus 94.37 0.00e+00 777.00
IUUC-Dre-027456 Danio rerio 74.72 0.00e+00 672.00
IUUC-Eca-033679 Equus caballus 90.38 0.00e+00 724.00
IUUC-Fca-036314 Felis catus 95.72 0.00e+00 788.00
IUUC-Fal-037300 Ficedula albicollis 84.30 0.00e+00 734.00
IUUC-Gmo-038571 Gadus morhua 67.92 2.00e-162 565.00
IUUC-Gga-040626 Gallus gallus 85.20 0.00e+00 691.00
IUUC-Gac-041445 Gasterosteus aculeatus 68.61 6.00e-165 573.00
IUUC-Ggo-045557 Gorilla gorilla 94.14 0.00e+00 776.00
IUUC-Hsa-045778 Homo sapiens 94.14 0.00e+00 776.00
IUUC-Itr-048856 Ictidomys tridecemlineatus 94.37 0.00e+00 779.00
IUUC-Lch-050070 Latimeria chalumnae 70.88 0.00e+00 665.00
IUUC-Loc-051764 Lepisosteus oculatus 77.85 0.00e+00 685.00
IUUC-Laf-054465 Loxodonta africana 93.48 0.00e+00 788.00
IUUC-Mcc-055324 Macaca mulatta 94.14 0.00e+00 778.00
IUUC-Meu-056348 Macropus eugenii 90.09 0.00e+00 739.00
IUUC-Mga-059285 Meleagris gallopavo 85.21 0.00e+00 677.00
IUUC-Mmr-061367 Microcebus murinus 95.05 0.00e+00 740.00
IUUC-Mdo-062432 Monodelphis domestica 57.94 6.00e-138 483.00
IUUC-Mmu-064347 Mus musculus 93.92 0.00e+00 814.00
IUUC-Mpu-066864 Mustela putorius furo 95.95 0.00e+00 789.00
IUUC-Nle-070027 Nomascus leucogenys 93.87 0.00e+00 732.00
IUUC-Ont-072188 Oreochromis niloticus 72.04 0.00e+00 637.00
IUUC-Ocu-074297 Oryctolagus cuniculus 96.40 0.00e+00 762.00
IUUC-Ola-087188 Oryzias latipes 71.81 3.00e-161 561.00
IUUC-Oga-088856 Otolemur garnettii 94.59 0.00e+00 758.00
IUUC-Oar-090278 Ovis aries 91.44 0.00e+00 674.00
IUUC-Pan-092056 Papio anubis 94.37 0.00e+00 777.00
IUUC-Pfo-097528 Poecilia formosa 68.46 7.00e-155 540.00
IUUC-Pab-098202 Pongo abelii 94.14 0.00e+00 777.00
IUUC-Pca-100881 Procavia capensis 93.24 0.00e+00 767.00
IUUC-Pva-102181 Pteropus vampyrus 94.82 0.00e+00 781.00
IUUC-Rno-105295 Rattus norvegicus 91.22 0.00e+00 756.00
IUUC-Sha-107163 Sarcophilus harrisii 75.74 0.00e+00 648.00
IUUC-Ssc-115685 Sus scrofa 95.27 0.00e+00 785.00
IUUC-Tgu-116524 Taeniopygia guttata 78.03 0.00e+00 650.00
IUUC-Tru-118248 Takifugu rubripes 68.75 2.00e-153 535.00
IUUC-Tni-120717 Tetraodon nigroviridis 69.57 7.00e-157 546.00
IUUC-Ttr-129069 Tursiops truncatus 96.45 0.00e+00 753.00
IUUC-Xtr-132759 Xenopus tropicalis 71.36 0.00e+00 651.00
Created Date 25-Jun-2017

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