iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000012207.3	ENSMMUT00000057178.1	ENSMMUP00000046927.1
ENSMMUG00000012207.3	ENSMMUT00000017096.3	ENSMMUP00000016010.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/CARD	3.80e-22	79.7	203	255

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 3    eeyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaa 55
           +e+rl+++t+++r+r+lLd+++v++++l++fll++++el+++ a + +++++ 
   Q: 203  DEIRLPIFTPSQRARRLLDLATVKANGLAAFLLQHVQELPVPLALPLEAATCR 255
           8*************************************************997 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MPTPFHFRFF EALHQPLSTD PTTIAELTML RDFLSCSEIL PGLEAPGGLL ALKFPEPTAG 60
CEMCSQEAFQ AQRSQLVELL VSGSLEGFES VLDWLLSWEV LSWEDYEGIH LLGQPLSHLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCTGCTC CCCAAGCCTA ATGGGCTTTG ATGGGGGAAG AGGGGGTGGT CCAGTCTCTC 60
CCGATGAGGA GGAAAGAGCA AGTGTCCTCC TTGGACATTT TCTGGGTAAG AGGAGCAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome

Interpro

IPR007109--Brix
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase
IPR027417--P-loop_NTPase

PROSITE

PS50209--CARD
PS51450--LRR
PS50837--NACHT

Pfam

PF00619--CARD
PF13516--LRR_6

Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0009986--C:cell surface
GO:0008180--C:COP9 signalosome
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0031982--C:vesicle
GO:0005524--F:ATP binding
GO:0032500--F:muramyl dipeptide binding
GO:0042834--F:peptidoglycan binding
GO:0071225--P:cellular response to muramyl dipeptide
GO:0002374--P:cytokine secretion involved in immune response
GO:0042742--P:defense response to bacterium
GO:0016045--P:detection of bacterium
GO:0032498--P:detection of muramyl dipeptide
GO:0045087--P:innate immune response
GO:0030277--P:maintenance of gastrointestinal epithelium
GO:0070431--P:nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0050871--P:positive regulation of B cell activation
GO:1900017--P:positive regulation of cytokine production involved in inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050718--P:positive regulation of interleukin-1 beta secretion
GO:0032740--P:positive regulation of interleukin-17 production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0046330--P:positive regulation of JNK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0002830--P:positive regulation of type 2 immune response
GO:0042981--P:regulation of apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001822	Ailuropoda melanoleuca	81.24	0.00e+00	1480.00
IUUC-Ame-011021	Astyanax mexicanus	45.97	0.00e+00	872.00
IUUC-Bta-013241	Bos taurus	81.54	0.00e+00	1619.00
IUUC-Cja-019633	Callithrix jacchus	90.77	0.00e+00	1373.00
IUUC-Cfa-020039	Canis familiaris	83.22	0.00e+00	1620.00
IUUC-Cpo-022337	Cavia porcellus	80.46	0.00e+00	1539.00
IUUC-Csa-023906	Chlorocebus sabaeus	99.21	0.00e+00	1948.00
IUUC-Dre-027568	Danio rerio	48.47	0.00e+00	841.00
IUUC-Dno-029098	Dasypus novemcinctus	81.12	0.00e+00	1495.00
IUUC-Dor-031102	Dipodomys ordii	74.84	0.00e+00	701.00
IUUC-Ete-032943	Echinops telfairi	76.70	0.00e+00	1113.00
IUUC-Eca-034310	Equus caballus	84.18	0.00e+00	1611.00
IUUC-Eeu-034589	Erinaceus europaeus	84.38	8.00e-165	574.00
IUUC-Fca-036252	Felis catus	79.62	0.00e+00	808.00
IUUC-Gac-041442	Gasterosteus aculeatus	46.10	0.00e+00	816.00
IUUC-Ggo-044861	Gorilla gorilla	96.46	0.00e+00	1824.00
IUUC-Hsa-046093	Homo sapiens	95.87	0.00e+00	1817.00
IUUC-Itr-048543	Ictidomys tridecemlineatus	81.77	0.00e+00	1477.00
IUUC-Lch-049454	Latimeria chalumnae	53.88	0.00e+00	926.00
IUUC-Laf-053553	Loxodonta africana	83.30	0.00e+00	1506.00
IUUC-Meu-056785	Macropus eugenii	53.40	4.00e-149	522.00
IUUC-Mvi-060491	Microbotryum violaceum	36.00	9.70e-01	28.90
IUUC-Mmr-060596	Microcebus murinus	84.27	0.00e+00	1600.00
IUUC-Mdo-062983	Monodelphis domestica	67.33	0.00e+00	1117.00
IUUC-Mmu-063951	Mus musculus	77.78	0.00e+00	1524.00
IUUC-Mpu-066412	Mustela putorius furo	82.53	0.00e+00	1614.00
IUUC-Mlu-067601	Myotis lucifugus	81.13	0.00e+00	1450.00
IUUC-Nle-069913	Nomascus leucogenys	95.37	0.00e+00	1515.00
IUUC-Opr-070999	Ochotona princeps	84.27	0.00e+00	990.00
IUUC-Ont-072512	Oreochromis niloticus	46.79	0.00e+00	889.00
IUUC-Oan-073564	Ornithorhynchus anatinus	62.30	0.00e+00	1105.00
IUUC-Ocu-074837	Oryctolagus cuniculus	86.54	0.00e+00	1646.00
IUUC-Ola-086555	Oryzias latipes	45.33	0.00e+00	811.00
IUUC-Oga-088909	Otolemur garnettii	84.18	0.00e+00	1611.00
IUUC-Oar-089315	Ovis aries	80.77	0.00e+00	1555.00
IUUC-Ptr-090542	Pan troglodytes	96.26	0.00e+00	1821.00
IUUC-Pan-092545	Papio anubis	99.21	0.00e+00	1911.00
IUUC-Pma-094167	Petromyzon marinus	33.18	6.00e-63	235.00
IUUC-Ppa-095344	Physcomitrella patens	36.92	1.00e-03	38.90
IUUC-Pfo-096976	Poecilia formosa	44.34	0.00e+00	822.00
IUUC-Pab-098481	Pongo abelii	95.96	0.00e+00	1810.00
IUUC-Pca-100135	Procavia capensis	77.06	0.00e+00	1300.00
IUUC-Pva-102127	Pteropus vampyrus	82.19	0.00e+00	1449.00
IUUC-Pte-104066	Pyrenophora teres	38.71	3.20e+00	28.50
IUUC-Rno-105783	Rattus norvegicus	79.80	0.00e+00	1506.00
IUUC-Sce-106163	Saccharomyces cerevisiae	25.96	3.70e-02	34.70
IUUC-Sar-113448	Sorex araneus	74.54	0.00e+00	923.00
IUUC-Tru-118708	Takifugu rubripes	44.54	0.00e+00	778.00
IUUC-Tni-120172	Tetraodon nigroviridis	36.84	2.00e-31	129.00
IUUC-Tbe-127661	Tupaia belangeri	87.15	0.00e+00	851.00
IUUC-Ttr-128318	Tursiops truncatus	78.05	0.00e+00	1428.00
IUUC-Vpa-130502	Vicugna pacos	73.95	5.00e-159	555.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence