iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	circBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
iRefIndex	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/ZnF_A20	ZnF_A20	16424905

Classification

Family	E-value	Score	Start	End
UBD/ZnF/ZnF_A20	1.80e-19	70.5	9	42

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/ZnF_A20

   S: 2    pskllCkkgCgfYGnpetngyCSkCyreelrrrr 35
           ++++lC++gCgfYGnp+tng+CS+Cy+e+l+r++
   Q: 9    QAPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQN 42
           89******************************95 PP

Organism

Mus musculus

Functional Description
(View)

Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1 (By similarity). Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes.

Protein Sequence
(Fasta)

MAQETNHSQA PMLCSTGCGF YGNPRTNGMC SVCYKEHLQR QNSSNGRISP PAASVSSLSE 60
SLPVQCADGS VPDAQSALDS TSSSMQPGPV SNQSLLSESV APSQVDSTSV DKAVSETEDL 120

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Nucleotide Sequence
(Fasta)

GCGTCAGCGC GCGTTGAGAG CCAATCGCGG GCGCTCCCTT GAGGCCGCGT CACAGGCCGA 60
GCAGCCAAAC AGAAAAGTTT AATAAACAGC GGACGGAGGG CCGGCGGCGG CGGGCCGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002653--Znf_A20
IPR000058--Znf_AN1

PROSITE

PS51036--ZF_A20
PS51039--ZF_AN1

Pfam

PF01754--zf-A20
PF01428--zf-AN1

SMART

SM00259--ZnF_A20
SM00154--ZnF_AN1

Gene Ontology

GO:0005737--C:cytoplasm
GO:0003677--F:DNA binding
GO:0031593--F:polyubiquitin binding
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0071356--P:cellular response to tumor necrosis factor
GO:0043066--P:negative regulation of apoptotic process
GO:0006625--P:protein targeting to peroxisome
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling

KEGG

mmu:65098

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001996	Ailuropoda melanoleuca	68.94	7.00e-83	299.00
IUUC-Apl-003230	Anas platyrhynchos	75.11	1.00e-90	325.00
IUUC-Aca-004458	Anolis carolinensis	72.57	2.00e-87	315.00
IUUC-Aly-005845	Arabidopsis lyrata	50.75	9.00e-20	89.40
IUUC-Ath-007039	Arabidopsis thaliana	50.62	2.00e-21	95.10
IUUC-Bol-015417	Brassica oleracea	31.63	2.00e-24	105.00
IUUC-Bra-017534	Brassica rapa	63.93	9.00e-22	96.30
IUUC-Cja-019854	Callithrix jacchus	87.44	8.00e-99	352.00
IUUC-Cfa-020592	Canis familiaris	87.44	3.00e-110	390.00
IUUC-Cpo-022191	Cavia porcellus	80.72	2.00e-86	311.00
IUUC-Csa-023200	Chlorocebus sabaeus	87.89	3.00e-96	343.00
IUUC-Cho-025055	Choloepus hoffmanni	75.86	1.00e-62	231.00
IUUC-Cme-027230	Cyanidioschyzon merolae	65.38	9.00e-07	46.60
IUUC-Dno-029778	Dasypus novemcinctus	87.89	7.00e-102	362.00
IUUC-Dor-030783	Dipodomys ordii	71.30	4.00e-68	250.00
IUUC-Dme-032180	Drosophila melanogaster	37.67	6.00e-33	133.00
IUUC-Ete-033057	Echinops telfairi	83.93	1.00e-98	351.00
IUUC-Eca-033680	Equus caballus	86.10	1.00e-101	362.00
IUUC-Fca-036284	Felis catus	86.49	3.00e-109	387.00
IUUC-Fal-036744	Ficedula albicollis	73.21	2.00e-86	311.00
IUUC-Gga-041083	Gallus gallus	72.77	2.00e-84	304.00
IUUC-Gma-043379	Glycine max	51.35	5.00e-19	87.00
IUUC-Ggo-045187	Gorilla gorilla	87.89	1.00e-99	355.00
IUUC-Hsa-046323	Homo sapiens	88.34	6.00e-103	366.00
IUUC-Itr-048209	Ictidomys tridecemlineatus	95.96	1.00e-115	408.00
IUUC-Lch-049537	Latimeria chalumnae	64.76	6.00e-72	263.00
IUUC-Loc-051871	Lepisosteus oculatus	61.33	7.00e-72	263.00
IUUC-Laf-053415	Loxodonta africana	93.72	2.00e-122	431.00
IUUC-Mcc-055523	Macaca mulatta	87.89	4.00e-96	343.00
IUUC-Meu-056041	Macropus eugenii	70.54	9.00e-81	292.00
IUUC-Mga-059999	Meleagris gallopavo	74.01	2.00e-87	314.00
IUUC-Mmr-061275	Microcebus murinus	80.72	1.00e-98	352.00
IUUC-Mdo-062315	Monodelphis domestica	84.82	4.00e-107	380.00
IUUC-Mac-065404	Musa acuminata	33.02	3.00e-24	104.00
IUUC-Mpu-066705	Mustela putorius furo	85.20	2.00e-106	378.00
IUUC-Mlu-067748	Myotis lucifugus	86.61	1.00e-93	335.00
IUUC-Nle-069143	Nomascus leucogenys	87.44	9.00e-98	349.00
IUUC-Opr-070483	Ochotona princeps	82.06	2.00e-89	321.00
IUUC-Oan-073186	Ornithorhynchus anatinus	75.89	2.00e-92	331.00
IUUC-Ocu-073771	Oryctolagus cuniculus	83.86	4.00e-86	310.00
IUUC-Oga-088957	Otolemur garnettii	86.10	1.00e-100	358.00
IUUC-Oar-089228	Ovis aries	86.10	4.00e-109	386.00
IUUC-Ptr-090990	Pan troglodytes	87.89	1.00e-99	355.00
IUUC-Pan-092389	Papio anubis	87.44	3.00e-96	343.00
IUUC-Psi-093513	Pelodiscus sinensis	74.55	9.00e-86	309.00
IUUC-Pma-094271	Petromyzon marinus	50.21	5.00e-55	207.00
IUUC-Ppa-095693	Physcomitrella patens	32.09	1.00e-23	102.00
IUUC-Pab-098666	Pongo abelii	88.34	6.00e-100	356.00
IUUC-Pca-100099	Procavia capensis	76.68	1.00e-89	322.00
IUUC-Pva-102935	Pteropus vampyrus	85.40	3.00e-97	347.00
IUUC-Rno-104975	Rattus norvegicus	100.00	2.00e-130	457.00
IUUC-Sha-106855	Sarcophilus harrisii	88.44	5.00e-113	400.00
IUUC-Smo-109137	Selaginella moellendorffii	59.21	7.00e-23	99.80
IUUC-Sly-111918	Solanum lycopersicum	36.00	7.00e-25	106.00
IUUC-Ssc-116012	Sus scrofa	78.54	4.00e-99	353.00
IUUC-Tgu-116855	Taeniopygia guttata	73.21	4.00e-87	313.00
IUUC-Tsy-119175	Tarsius syrichta	82.06	2.00e-100	358.00
IUUC-Ttr-128188	Tursiops truncatus	87.89	1.00e-82	298.00
IUUC-Vpa-130770	Vicugna pacos	88.34	5.00e-93	333.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence