iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-034202

UUCD1 version

UUC-EqC-00509

Ensembl Protein ID

ENSECAP00000021352.1

UniProt Accession

F6YEM4; F6YEM4_HORSE

Protein Name

Uncharacterized protein

Gene Name

HECTD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000023602.1	ENSECAT00000025656.1	ENSECAP00000021352.1
ENSECAG00000023602.1	ENSECAT00000025663.1	ENSECAP00000021359.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.50e-79	265.7	3635	3995

Active Site

Position(s)	Description	Evidence
3969	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           d ++ ++++f+gEe+++++G++r+fl++++kelq+++l+l+       ++++++k+ l+p+p ++     +++l +flG+llg+a++
   Q: 3635 DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLllcpssaVNKNKGKYILTPSPLTY----GEEQLLHFLGQLLGIAIR 3717
           5667788*********************************9999999888888*********999....789*************** PP
   S: 84   dgrlldlplsksfyklllgkklsl.edleevdpelyks.lkeikenaesdieelgldltfs..vseei...............lget 151
            + +l+l+l +sf+k+l+g++l+  +dl+e d  +y++ +k+ + n+e+++e+l+++++++  +  ++                 + 
   Q: 3718 ADVPLPLDLLPSFWKTLVGEPLDPdQDLQEADVLTYNYvKKFESINDETELEALCAEIASQhlA--TEspdspnkpccrftylTMTG 3802
           **************************************56666677789999999999999532..33468999*******655555 PP
   S: 152  keeeLkpgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykg 237
           +e+eL+++G++ipV++eNk+ Y  ++ ++rl+e +  e+v+a+r+G+  +ipl+ll+ +++ e+el +cG ++i++e lk++t+y+ 
   Q: 3803 EEVELCSRGRHIPVAWENKDIYAAAIRSLRLRElENVECVTAVRAGLGAIIPLQLLTTLSPLEMELRTCGLPYINLEFLKAHTMYQV 3889
           6667*****************************99**************************************************** PP
   S: 238  gytedspaiqwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkLP 311
           g++e++++i++Fw +le+f +ee ++f++F+++++r+P+      gG ++ +    p+++  ++    ++d+r+++++TC++++kLP
   Q: 3890 GLMETDQHIEFFWGALEMFAQEELCKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgtaGSADSRYIRVETCMFMIKLP 3976
           *********************************************99999999988888888889977778**************** PP
   S: 312  eYsskeilkekLlyAieet 330
           +Yss ei+ ekL++Ai+++
   Q: 3977 QYSSLEIMLEKLRCAIHYR 3995
           ****************986 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MVPMPANHLP VGSTVSTVHL SSDGTYFYWI WSPASLNEKT PKGHSVFMDI FELVVEDGVF 60
VANPLQERTI LMRKEGESAK SINEMLLSRL SRYRASPSAT LAALTGSTIS NTLKEDQAAN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTGCCAGA TGGTACCAAT GCCAGCCAAT CACCTCCCTG TTGGCAGTAC TGTGAGCACT 60
GTGCACCTTT CTTCAGATGG CACTTACTTC TATTGGATCT GGTCACCTGC CAGTCTGAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	98.25	0.00e+00	7308.00
IUUC-Apl-004161	Anas platyrhynchos	92.70	0.00e+00	5194.00
IUUC-Aca-005341	Anolis carolinensis	89.72	0.00e+00	6684.00
IUUC-Ame-011574	Astyanax mexicanus	80.66	0.00e+00	4493.00
IUUC-Bta-012514	Bos taurus	97.42	0.00e+00	1946.00
IUUC-Cja-019148	Callithrix jacchus	96.86	0.00e+00	5289.00
IUUC-Cfa-020499	Canis familiaris	96.95	0.00e+00	7272.00
IUUC-Cpo-021894	Cavia porcellus	97.11	0.00e+00	2766.00
IUUC-Csa-023079	Chlorocebus sabaeus	96.58	0.00e+00	7268.00
IUUC-Cho-024415	Choloepus hoffmanni	94.27	0.00e+00	5102.00
IUUC-Dre-027452	Danio rerio	79.27	0.00e+00	4499.00
IUUC-Dno-029595	Dasypus novemcinctus	96.09	0.00e+00	7240.00
IUUC-Dor-030849	Dipodomys ordii	96.58	0.00e+00	1791.00
IUUC-Ete-032563	Echinops telfairi	90.42	0.00e+00	1635.00
IUUC-Eeu-035175	Erinaceus europaeus	96.75	0.00e+00	1076.00
IUUC-Fca-036295	Felis catus	96.61	0.00e+00	7062.00
IUUC-Fal-037003	Ficedula albicollis	91.81	0.00e+00	6242.00
IUUC-Gmo-038579	Gadus morhua	84.87	0.00e+00	2861.00
IUUC-Gga-040961	Gallus gallus	91.91	0.00e+00	7008.00
IUUC-Gac-041899	Gasterosteus aculeatus	84.58	0.00e+00	2898.00
IUUC-Ggo-045099	Gorilla gorilla	97.84	0.00e+00	6432.00
IUUC-Hsa-046331	Homo sapiens	96.83	0.00e+00	7342.00
IUUC-Itr-048190	Ictidomys tridecemlineatus	96.77	0.00e+00	2182.00
IUUC-Lch-049923	Latimeria chalumnae	86.27	0.00e+00	2666.00
IUUC-Loc-052630	Lepisosteus oculatus	84.00	0.00e+00	4040.00
IUUC-Laf-053394	Loxodonta africana	96.36	0.00e+00	7348.00
IUUC-Mcc-055763	Macaca mulatta	96.58	0.00e+00	7257.00
IUUC-Meu-056039	Macropus eugenii	89.24	0.00e+00	5083.00
IUUC-Mga-059500	Meleagris gallopavo	92.69	0.00e+00	7020.00
IUUC-Mmr-060868	Microcebus murinus	92.90	0.00e+00	6985.00
IUUC-Mdo-062772	Monodelphis domestica	93.15	0.00e+00	7086.00
IUUC-Mmu-063606	Mus musculus	95.22	0.00e+00	7200.00
IUUC-Mpu-065860	Mustela putorius furo	96.00	0.00e+00	7148.00
IUUC-Mlu-067376	Myotis lucifugus	98.11	0.00e+00	5412.00
IUUC-Nle-069693	Nomascus leucogenys	96.53	0.00e+00	7231.00
IUUC-Opr-071065	Ochotona princeps	94.72	0.00e+00	1218.00
IUUC-Ont-072470	Oreochromis niloticus	83.37	0.00e+00	4655.00
IUUC-Oan-073693	Ornithorhynchus anatinus	92.33	0.00e+00	5226.00
IUUC-Ocu-074032	Oryctolagus cuniculus	95.30	0.00e+00	7233.00
IUUC-Ola-087433	Oryzias latipes	83.38	0.00e+00	1584.00
IUUC-Oga-088546	Otolemur garnettii	97.91	0.00e+00	6977.00
IUUC-Oar-089643	Ovis aries	92.14	0.00e+00	766.00
IUUC-Ptr-090504	Pan troglodytes	97.95	0.00e+00	7354.00
IUUC-Pan-092543	Papio anubis	96.49	0.00e+00	7249.00
IUUC-Psi-093952	Pelodiscus sinensis	90.46	0.00e+00	6883.00
IUUC-Pfo-096356	Poecilia formosa	80.02	0.00e+00	6227.00
IUUC-Pab-098240	Pongo abelii	96.53	0.00e+00	7261.00
IUUC-Pca-100994	Procavia capensis	97.25	0.00e+00	3006.00
IUUC-Pva-102263	Pteropus vampyrus	96.77	0.00e+00	7178.00
IUUC-Rno-104888	Rattus norvegicus	95.15	0.00e+00	7167.00
IUUC-Sha-106944	Sarcophilus harrisii	93.74	0.00e+00	7133.00
IUUC-Sar-113556	Sorex araneus	84.30	0.00e+00	1003.00
IUUC-Ssc-116187	Sus scrofa	98.18	0.00e+00	5198.00
IUUC-Tgu-116655	Taeniopygia guttata	92.45	0.00e+00	5152.00
IUUC-Tru-118093	Takifugu rubripes	83.50	0.00e+00	2996.00
IUUC-Tni-119739	Tetraodon nigroviridis	83.59	0.00e+00	1611.00
IUUC-Tbe-127962	Tupaia belangeri	93.02	0.00e+00	1217.00
IUUC-Ttr-128819	Tursiops truncatus	93.59	0.00e+00	2898.00
IUUC-Vpa-130482	Vicugna pacos	95.81	0.00e+00	4484.00
IUUC-Xtr-132222	Xenopus tropicalis	87.09	0.00e+00	6637.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence