iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012934

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase ZNRF1; RING-type E3 ubiquitin transferase ZNRF1; Zinc/RING finger protein 1

Genbank Nucleotide ID

DAAA02045987

Gene Name

ZNRF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000034689.3	ENSBTAT00000049126.3	ENSBTAP00000046062.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	97.36	8.00e-128	453.00	IUUC-Hsa-046894

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes degeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (By similarity).

Protein Sequence
(Fasta)

MGGKQSTAAR SRGPFPGVST DDSAVPPPGG APHFGHYRAG GGAMGLRSRS VSSVAGMGMD 60
PSSAGGVSFG LYTPASRGAG DAERAPGSGG SASDSTYAHG NGYQETGGGH HRDGMLYLGS 120

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Nucleotide Sequence
(Fasta)

CCTTCCCCTC CGGTCTCCTT TCTGTCCCCC CCCTCCCCCG TATGCCAGCC CAGCCCTGCC 60
CCCGCCGCTG AGGACAGGGG GAGGGTCTCG GCCTGCAGGC TCCCGCCCCG CCGGGGCCCG 120

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Sequence Source

Ensembl

Keyword

KW-0965--Cell junction
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0967--Endosome
KW-0449--Lipoprotein
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0519--Myristate
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0770--Synapse
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0030054--C:cell junction
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0005764--C:lysosome
GO:0030672--C:synaptic vesicle membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination

KEGG

bta:509076

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-004093	Anas platyrhynchos	95.45	3.00e-60	222.00
IUUC-Cja-019419	Callithrix jacchus	96.48	4.00e-128	450.00
IUUC-Cfa-020388	Canis familiaris	97.28	3.00e-104	370.00
IUUC-Cpo-021584	Cavia porcellus	96.48	3.00e-128	450.00
IUUC-Cin-025162	Ciona intestinalis	46.56	1.00e-33	136.00
IUUC-Dre-027713	Danio rerio	76.21	2.00e-94	338.00
IUUC-Dse-031322	Dothistroma septosporum	46.81	6.00e-09	55.80
IUUC-Eca-033414	Equus caballus	100.00	8.00e-66	241.00
IUUC-Fca-036570	Felis catus	97.80	1.00e-129	454.00
IUUC-Fal-037096	Ficedula albicollis	96.30	1.00e-76	278.00
IUUC-Fso-038176	Fusarium solani	51.02	1.00e-08	55.10
IUUC-Gga-041242	Gallus gallus	87.72	1.00e-95	341.00
IUUC-Hsa-046894	Homo sapiens	97.36	3.00e-129	453.00
IUUC-Itr-048339	Ictidomys tridecemlineatus	100.00	5.00e-49	184.00
IUUC-Kpa-049401	Komagataella pastoris	32.67	8.00e-09	53.90
IUUC-Lch-049749	Latimeria chalumnae	69.72	2.00e-39	154.00
IUUC-Loc-052268	Lepisosteus oculatus	79.74	2.00e-95	341.00
IUUC-Laf-054263	Loxodonta africana	98.24	3.00e-130	456.00
IUUC-Mla-059140	Melampsora laricipopulina	33.33	5.00e-05	42.00
IUUC-Mga-059226	Meleagris gallopavo	98.82	1.00e-48	183.00
IUUC-Mmu-064275	Mus musculus	96.48	3.00e-128	450.00
IUUC-Mpu-066334	Mustela putorius furo	97.80	1.00e-129	454.00
IUUC-Mlu-067491	Myotis lucifugus	96.05	7.00e-123	432.00
IUUC-Ont-071907	Oreochromis niloticus	70.93	7.00e-82	296.00
IUUC-Oan-072941	Ornithorhynchus anatinus	88.10	4.00e-39	152.00
IUUC-Ocu-074256	Oryctolagus cuniculus	96.48	6.00e-125	439.00
IUUC-Ola-087551	Oryzias latipes	90.80	1.00e-46	177.00
IUUC-Pfo-097234	Poecilia formosa	73.68	6.00e-90	323.00
IUUC-Pab-098719	Pongo abelii	97.36	3.00e-129	453.00
IUUC-Rno-105985	Rattus norvegicus	96.04	8.00e-128	449.00
IUUC-Sja-107832	Schizosaccharomyces japonicus	34.26	1.00e-09	56.60
IUUC-Sre-115192	Sporisorium reilianum	38.78	2.00e-15	79.00
IUUC-Tgu-116682	Taeniopygia guttata	87.57	7.00e-82	295.00
IUUC-Tre-122233	Trichoderma reesei	32.32	9.00e-07	48.90
IUUC-Tvi-122664	Trichoderma virens	35.04	4.00e-09	56.60
IUUC-Tme-127002	Tuber melanosporum	56.25	1.00e-10	60.80
IUUC-Uma-129459	Ustilago maydis	37.62	4.00e-15	77.40
IUUC-Vda-129847	Verticillium dahliae	54.00	5.00e-10	59.30
IUUC-Xtr-132972	Xenopus tropicalis	64.32	3.00e-62	231.00
IUUC-Xma-134213	Xiphophorus maculatus	73.57	3.00e-89	320.00
IUUC-Yli-134502	Yarrowia lipolytica	30.81	6.00e-13	67.80

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence