iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-107081

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin thioesterase

Genbank Nucleotide ID

AEFK01223733

Gene Name

OTUB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000004156.1	ENSSHAT00000004781.1	ENSSHAP00000004733.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	3.90e-51	173.2	109	299

Active Site

Position(s)	Description	Evidence
116	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
119	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
293		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+kt++DGnC++rA+++s                                                          ll++f+d+s+sd
   Q: 109  YIRKTRPDGNCFYRAFGFShlealledskelqrfkaisakskedlvsqgfteftiedfhntfmdlieqvekrtsvadLLASFNDQSTSD 197
           89*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           +lv++Lr+lts ylq+es+ff++fie+++++kefcq++vep++k +++ihi+aLaq+Ls++i+v+++d++e   gg+++p++fpe + +
   Q: 198  YLVVYLRLLTSGYLQRESKFFEHFIEGGRTVKEFCQQEVEPMCKeSDHIHIIALAQALSVSIQVEYMDRGE---GGTTNPHVFPEGS-E 282
           **********************************************************************9...9************.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlYr+gHYd+L++
   Q: 283  PKVYLLYRPGHYDILYK 299
           ***************96 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

RRGGCSLPGG EALITRKWSW VRRCLKMAAE EPQQQKPEEA PLVAPPRGVN CLAYDEAIMA 60
QQDRIQQEIA VQNPLVSERL ELSVLYKEYA EDDNIYQQKI KDLHKKYSYI RKTRPDGNCF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCGGGGCG GTTGTTCACT TCCGGGAGGA GAAGCGCTAA TAACCCGGAA GTGGTCGTGG 60
GTGCGGCGCT GTTTAAAGAT GGCGGCGGAG GAACCTCAGC AGCAGAAGCC GGAGCCNNNN 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	92.64	5.00e-163	566.00
IUUC-Apl-003233	Anas platyrhynchos	60.00	3.00e-19	85.90
IUUC-Aca-004648	Anolis carolinensis	84.42	3.00e-135	473.00
IUUC-Aly-005710	Arabidopsis lyrata	40.96	7.00e-53	200.00
IUUC-Ath-007112	Arabidopsis thaliana	43.63	4.00e-51	194.00
IUUC-Ame-010662	Astyanax mexicanus	84.52	6.00e-128	449.00
IUUC-Bta-013533	Bos taurus	96.90	9.00e-149	518.00
IUUC-Bol-016100	Brassica oleracea	43.41	1.00e-50	192.00
IUUC-Bra-017705	Brassica rapa	40.22	2.00e-45	175.00
IUUC-Cja-019190	Callithrix jacchus	93.31	1.00e-157	548.00
IUUC-Cfa-020430	Canis familiaris	98.41	3.00e-148	516.00
IUUC-Cpo-022355	Cavia porcellus	96.90	4.00e-149	520.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	38.54	1.00e-46	179.00
IUUC-Csa-023286	Chlorocebus sabaeus	93.26	3.00e-146	510.00
IUUC-Csv-026273	Ciona savignyi	46.69	2.00e-69	255.00
IUUC-Dre-027843	Danio rerio	78.39	6.00e-126	442.00
IUUC-Dno-029165	Dasypus novemcinctus	97.00	2.00e-116	410.00
IUUC-Dor-030943	Dipodomys ordii	96.90	4.00e-149	520.00
IUUC-Dme-031922	Drosophila melanogaster	56.40	3.00e-78	284.00
IUUC-Ete-032296	Echinops telfairi	95.60	4.00e-88	317.00
IUUC-Eca-033695	Equus caballus	98.02	9.00e-148	515.00
IUUC-Fca-036441	Felis catus	94.38	1.00e-148	518.00
IUUC-Gmo-038908	Gadus morhua	78.60	4.00e-125	440.00
IUUC-Ggr-040020	Gaeumannomyces graminis	31.69	1.00e-33	137.00
IUUC-Gga-040460	Gallus gallus	81.68	3.00e-130	457.00
IUUC-Gac-042417	Gasterosteus aculeatus	80.40	1.00e-121	429.00
IUUC-Ggo-044552	Gorilla gorilla	98.11	7.00e-91	326.00
IUUC-Hsa-046766	Homo sapiens	96.51	5.00e-149	519.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	96.90	4.00e-149	520.00
IUUC-Lch-050602	Latimeria chalumnae	80.95	1.00e-118	418.00
IUUC-Laf-053705	Loxodonta africana	96.90	4.00e-149	520.00
IUUC-Mcc-055745	Macaca mulatta	90.22	1.00e-144	504.00
IUUC-Meu-056569	Macropus eugenii	84.25	1.00e-131	462.00
IUUC-Mmr-061123	Microcebus murinus	95.89	4.00e-122	430.00
IUUC-Mdo-062613	Monodelphis domestica	85.77	1.00e-119	422.00
IUUC-Mmu-063658	Mus musculus	96.90	4.00e-149	520.00
IUUC-Mpu-066172	Mustela putorius furo	96.51	5.00e-149	519.00
IUUC-Mlu-066966	Myotis lucifugus	92.98	8.00e-158	549.00
IUUC-Nle-069519	Nomascus leucogenys	96.89	2.00e-91	328.00
IUUC-Ont-071901	Oreochromis niloticus	81.67	5.00e-124	436.00
IUUC-Ola-087331	Oryzias latipes	80.90	1.00e-85	308.00
IUUC-Oga-088064	Otolemur garnettii	96.51	5.00e-149	519.00
IUUC-Oar-089251	Ovis aries	98.80	8.00e-147	512.00
IUUC-Ptr-091430	Pan troglodytes	93.31	1.00e-157	548.00
IUUC-Psi-093823	Pelodiscus sinensis	90.20	1.00e-133	468.00
IUUC-Pma-094366	Petromyzon marinus	70.74	2.00e-102	364.00
IUUC-Pfo-096734	Poecilia formosa	79.68	3.00e-113	400.00
IUUC-Pab-097919	Pongo abelii	98.59	4.00e-122	430.00
IUUC-Pva-102499	Pteropus vampyrus	98.41	7.00e-148	515.00
IUUC-Rno-105233	Rattus norvegicus	96.90	4.00e-149	520.00
IUUC-Ssc-116202	Sus scrofa	96.51	5.00e-149	519.00
IUUC-Tru-117664	Takifugu rubripes	74.91	2.00e-120	424.00
IUUC-Tbe-128116	Tupaia belangeri	96.89	1.00e-91	329.00
IUUC-Ttr-128622	Tursiops truncatus	95.74	3.00e-146	510.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence