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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064268
Ensembl Protein ID ENSMUSP00000041955.3
UniProt Accession Q91VL9; Q8CDP7; Q99LD2; ZBTB1_MOUSE
Genbank Protein ID BAC26603.1; BAC28921.1; BAC33733.1; AAH03372.1; AAH12239.1
Protein Name Zinc finger and BTB domain-containing protein 1
Genbank Nucleotide ID AK029762; AK035036; AK049397; BC003372; BC012239
Gene Name Zbtb1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000033454.6 ENSMUST00000042779.3 ENSMUSP00000041955.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 1.50e-12 48.8 24 87
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalf.lmeleesksklmveikdvqpevfrallkFlYtgkl 65
           +D+++ +++ +f+ahk+vLaa+Ss+F+  f +++ +  +  +  ++k +++e+f  +l+F+Y gk+
   Q: 24   CDCCIAIDDIYFQAHKAVLAACSSYFRMFFmNHQHSTAQ-LNLSNMK-ISAECFDLILQFMYLGKI 87
           8*************************9999333333333.5555666.****************97 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Acts as a transcriptional repressor (By similarity). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (By similarity). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (By similarity). Plays a key role in the transcriptional regulation of T lymphocyte development (PubMed:22201126, PubMed:22753936).
 Acts as a transcriptional repressor (By similarity). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (By similarity). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (By similarity). Plays a key role in the transcriptional regulation of T lymphocyte development (PubMed:22201126, PubMed:22753936).
Protein Sequence
(Fasta)
MAKPSHSSYV LQQLNNQREW GFLCDCCIAI DDIYFQAHKA VLAACSSYFR MFFMNHQHST 60
AQLNLSNMKI SAECFDLILQ FMYLGKIMTA PSSFEQFKVA MNYLQLYNVP DCLEDIQDAD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064268|E3,BTB_Other|Mus musculus
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Nucleotide Sequence
(Fasta)
GAGGAGGGCC AAGCCGACTC CGGGGAGAGG GGCGACAGTG CTGCTCCAGC CGCCGCCGCC 60
CGGGCGCCCG CGCTGCGGGC AGTGCCAGCC TCCCCGGCCC GACGCAGAAA CTTGTTGCAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064268|E3,BTB_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0221--Differentiation
KW-0238--DNA-binding
KW-0391--Immunity
KW-0399--Innate immunity
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0016604--C:nuclear body
GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0030183--P:B cell differentiation
GO:0006974--P:cellular response to DNA damage stimulus
GO:0034644--P:cellular response to UV
GO:0006338--P:chromatin remodeling
GO:0006281--P:DNA repair
GO:0045087--P:innate immune response
GO:0042789--P:mRNA transcription from RNA polymerase II promoter
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032825--P:positive regulation of natural killer cell differentiation
GO:2000176--P:positive regulation of pro-T cell differentiation
GO:0045582--P:positive regulation of T cell differentiation
GO:0002711--P:positive regulation of T cell mediated immunity
GO:0051260--P:protein homooligomerization
GO:0033077--P:T cell differentiation in thymus
GO:0048538--P:thymus development
GO:0019985--P:translesion synthesis
KEGG mmu:268564
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001844 Ailuropoda melanoleuca 93.28 0.00e+00 1307.00
IUUC-Apl-003725 Anas platyrhynchos 78.84 0.00e+00 1097.00
IUUC-Aca-004672 Anolis carolinensis 70.40 0.00e+00 941.00
IUUC-Ame-011859 Astyanax mexicanus 48.70 7.00e-178 617.00
IUUC-Bta-013323 Bos taurus 94.40 0.00e+00 1358.00
IUUC-Cja-018727 Callithrix jacchus 94.68 0.00e+00 1320.00
IUUC-Cfa-020390 Canis familiaris 93.69 0.00e+00 1323.00
IUUC-Cpo-022434 Cavia porcellus 93.55 0.00e+00 1349.00
IUUC-Csa-023909 Chlorocebus sabaeus 92.73 0.00e+00 1132.00
IUUC-Cho-024288 Choloepus hoffmanni 92.98 0.00e+00 906.00
IUUC-Dre-027623 Danio rerio 47.57 5.00e-179 621.00
IUUC-Dno-029224 Dasypus novemcinctus 94.82 0.00e+00 1358.00
IUUC-Ete-032672 Echinops telfairi 88.28 0.00e+00 951.00
IUUC-Eca-034361 Equus caballus 93.52 0.00e+00 1146.00
IUUC-Eeu-035254 Erinaceus europaeus 88.03 4.00e-149 521.00
IUUC-Fca-036217 Felis catus 93.84 0.00e+00 1348.00
IUUC-Fal-037026 Ficedula albicollis 76.01 0.00e+00 929.00
IUUC-Gga-040550 Gallus gallus 74.00 7.00e-135 473.00
IUUC-Gac-041379 Gasterosteus aculeatus 46.17 8.00e-168 583.00
IUUC-Ggo-044852 Gorilla gorilla 94.82 0.00e+00 1358.00
IUUC-Hsa-046418 Homo sapiens 94.96 0.00e+00 1360.00
IUUC-Itr-048065 Ictidomys tridecemlineatus 93.70 0.00e+00 1340.00
IUUC-Lch-050025 Latimeria chalumnae 54.88 0.00e+00 769.00
IUUC-Loc-052590 Lepisosteus oculatus 50.41 0.00e+00 649.00
IUUC-Laf-054526 Loxodonta africana 93.70 0.00e+00 1330.00
IUUC-Mcc-055796 Macaca mulatta 93.42 0.00e+00 1303.00
IUUC-Mga-059889 Meleagris gallopavo 79.25 0.00e+00 1109.00
IUUC-Mmr-061304 Microcebus murinus 94.12 0.00e+00 1316.00
IUUC-Mdo-062964 Monodelphis domestica 87.39 0.00e+00 1250.00
IUUC-Mpu-065817 Mustela putorius furo 92.26 0.00e+00 1133.00
IUUC-Mlu-068225 Myotis lucifugus 93.70 0.00e+00 1323.00
IUUC-Nle-069390 Nomascus leucogenys 94.68 0.00e+00 1357.00
IUUC-Opr-070274 Ochotona princeps 91.46 0.00e+00 1292.00
IUUC-Ont-072145 Oreochromis niloticus 46.66 4.00e-170 591.00
IUUC-Oan-073144 Ornithorhynchus anatinus 82.61 0.00e+00 994.00
IUUC-Ocu-074835 Oryctolagus cuniculus 87.11 0.00e+00 1214.00
IUUC-Ola-087520 Oryzias latipes 47.40 8.00e-167 580.00
IUUC-Oga-088605 Otolemur garnettii 93.70 0.00e+00 1343.00
IUUC-Oar-089788 Ovis aries 94.40 0.00e+00 1358.00
IUUC-Ptr-091274 Pan troglodytes 94.96 0.00e+00 1360.00
IUUC-Psi-093560 Pelodiscus sinensis 77.52 0.00e+00 976.00
IUUC-Pfo-097221 Poecilia formosa 44.28 3.00e-167 582.00
IUUC-Pab-097799 Pongo abelii 94.47 0.00e+00 1190.00
IUUC-Pva-102769 Pteropus vampyrus 92.72 0.00e+00 1313.00
IUUC-Rno-105959 Rattus norvegicus 93.83 0.00e+00 1196.00
IUUC-Sha-106613 Sarcophilus harrisii 87.11 0.00e+00 1243.00
IUUC-Sar-112951 Sorex araneus 83.54 0.00e+00 1048.00
IUUC-Ssc-115673 Sus scrofa 94.12 0.00e+00 1313.00
IUUC-Tgu-116806 Taeniopygia guttata 78.28 0.00e+00 1077.00
IUUC-Tru-117544 Takifugu rubripes 44.08 5.00e-133 468.00
IUUC-Tsy-119233 Tarsius syrichta 86.41 0.00e+00 1194.00
IUUC-Tni-120273 Tetraodon nigroviridis 44.65 6.00e-157 547.00
IUUC-Tbe-128020 Tupaia belangeri 93.04 0.00e+00 1141.00
IUUC-Ttr-128357 Tursiops truncatus 94.12 0.00e+00 1311.00
IUUC-Vpa-130487 Vicugna pacos 94.12 0.00e+00 1352.00
IUUC-Xtr-132415 Xenopus tropicalis 58.14 0.00e+00 787.00
Created Date 25-Jun-2017

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