iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098702

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase RNF139

Genbank Nucleotide ID

ABGA01324805

Gene Name

RNF139

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000018867.1	ENSPPYT00000022011.1	ENSPPYP00000021168.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.80e-09	37.0	547	585

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC+ +f +  +++pC+H fha Cl kw       + +++CP C
   Q: 547  CAICYHEFTTSARITPCNHYFHALCLRKW------LYIQDTCPMC 585
           ********999******************......********** PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MAAVGPPQQQ VRMAHQQVWA ALEVALRVPC LYIIDAIFNS YPDSSQSRFC IVLQIFLRLL 60
GVFVSSIVLI LSQRSLFKFY MYSSAFLLAA TSVLVNYYAS LHIDFYGAYN TSAFGIELLP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGTGGCAG CGGCTCATGG CGGCCGTGGG GCCCCCGCAG CAGCAGGTGC GGATGGCCCA 60
TCAGCAGGTC TGGGCGGCGC TCGAAGTGGC GCTCCGGGTG CCCTGCCTTT ACATCATCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR025754--TRC8_N_dom
IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13705--TRC8_N
PF13639--zf-RING_2

SMART

SM00184--RING
SM00744--RINGv

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0036503--P:ERAD pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0017148--P:negative regulation of translation
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031648--P:protein destabilization
GO:0060628--P:regulation of ER to Golgi vesicle-mediated transport
GO:0070613--P:regulation of protein processing

KEGG

pon:100447707

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002401	Ailuropoda melanoleuca	97.43	0.00e+00	1212.00
IUUC-Apl-004214	Anas platyrhynchos	85.87	0.00e+00	961.00
IUUC-Aca-005326	Anolis carolinensis	78.59	0.00e+00	973.00
IUUC-Ame-011687	Astyanax mexicanus	74.04	0.00e+00	870.00
IUUC-Bta-013394	Bos taurus	96.39	0.00e+00	1245.00
IUUC-Bci-013813	Botrytis cinerea	41.38	5.00e-08	52.00
IUUC-Cja-019499	Callithrix jacchus	96.99	0.00e+00	1285.00
IUUC-Cfa-020357	Canis familiaris	96.99	0.00e+00	1220.00
IUUC-Cpo-021924	Cavia porcellus	94.93	0.00e+00	1161.00
IUUC-Csa-023513	Chlorocebus sabaeus	99.55	0.00e+00	1284.00
IUUC-Cho-024285	Choloepus hoffmanni	89.92	0.00e+00	1081.00
IUUC-Cin-025223	Ciona intestinalis	53.93	7.00e-75	273.00
IUUC-Csv-026018	Ciona savignyi	47.92	1.00e-64	239.00
IUUC-Dre-028660	Danio rerio	72.53	0.00e+00	788.00
IUUC-Dno-029463	Dasypus novemcinctus	96.12	5.00e-166	577.00
IUUC-Dor-030728	Dipodomys ordii	94.44	0.00e+00	1109.00
IUUC-Dse-031284	Dothistroma septosporum	43.40	4.00e-09	55.10
IUUC-Dme-032186	Drosophila melanogaster	44.27	7.00e-98	351.00
IUUC-Ete-032368	Echinops telfairi	87.71	0.00e+00	1157.00
IUUC-Eca-034325	Equus caballus	96.09	0.00e+00	1189.00
IUUC-Fca-035537	Felis catus	95.25	0.00e+00	1167.00
IUUC-Fal-037459	Ficedula albicollis	85.10	0.00e+00	935.00
IUUC-Gmo-039442	Gadus morhua	78.65	2.00e-97	349.00
IUUC-Ggr-039921	Gaeumannomyces graminis	31.91	8.00e-08	52.80
IUUC-Gga-041071	Gallus gallus	82.82	0.00e+00	996.00
IUUC-Gac-042483	Gasterosteus aculeatus	66.57	0.00e+00	889.00
IUUC-Ggo-044672	Gorilla gorilla	99.85	0.00e+00	1335.00
IUUC-Hsa-045836	Homo sapiens	99.10	0.00e+00	1249.00
IUUC-Itr-048588	Ictidomys tridecemlineatus	95.89	0.00e+00	1248.00
IUUC-Lch-050073	Latimeria chalumnae	73.20	0.00e+00	969.00
IUUC-Loc-052908	Lepisosteus oculatus	70.53	0.00e+00	935.00
IUUC-Laf-053519	Loxodonta africana	93.23	0.00e+00	1246.00
IUUC-Mcc-054674	Macaca mulatta	97.99	3.00e-109	387.00
IUUC-Mor-057262	Magnaporthe oryzae	32.93	3.00e-08	53.90
IUUC-Mga-059922	Meleagris gallopavo	85.92	0.00e+00	956.00
IUUC-Mmr-061452	Microcebus murinus	95.20	0.00e+00	1197.00
IUUC-Mdo-062412	Monodelphis domestica	89.29	0.00e+00	1166.00
IUUC-Mmu-063147	Mus musculus	93.71	0.00e+00	1205.00
IUUC-Mpu-065929	Mustela putorius furo	96.84	0.00e+00	1221.00
IUUC-Mlu-067899	Myotis lucifugus	92.93	0.00e+00	1201.00
IUUC-Nle-070083	Nomascus leucogenys	99.55	0.00e+00	1283.00
IUUC-Opr-070461	Ochotona princeps	91.45	0.00e+00	1213.00
IUUC-Ont-072256	Oreochromis niloticus	70.33	0.00e+00	909.00
IUUC-Oan-073150	Ornithorhynchus anatinus	85.07	0.00e+00	934.00
IUUC-Ocu-073748	Oryctolagus cuniculus	93.55	0.00e+00	1202.00
IUUC-Oga-088565	Otolemur garnettii	96.50	0.00e+00	1225.00
IUUC-Oar-089432	Ovis aries	96.52	0.00e+00	1159.00
IUUC-Ptr-091422	Pan troglodytes	99.70	0.00e+00	1285.00
IUUC-Pan-092331	Papio anubis	99.40	0.00e+00	1282.00
IUUC-Psi-092933	Pelodiscus sinensis	84.04	0.00e+00	937.00
IUUC-Pfo-097466	Poecilia formosa	69.85	0.00e+00	905.00
IUUC-Pca-100125	Procavia capensis	91.09	0.00e+00	1188.00
IUUC-Pva-102628	Pteropus vampyrus	96.68	0.00e+00	1212.00
IUUC-Rno-104886	Rattus norvegicus	93.90	0.00e+00	1216.00
IUUC-Sha-106702	Sarcophilus harrisii	86.57	0.00e+00	1139.00
IUUC-Ssc-116164	Sus scrofa	95.34	0.00e+00	1255.00
IUUC-Tgu-116829	Taeniopygia guttata	83.53	0.00e+00	972.00
IUUC-Tru-118557	Takifugu rubripes	69.88	0.00e+00	868.00
IUUC-Tsy-119399	Tarsius syrichta	91.97	0.00e+00	674.00
IUUC-Tni-120006	Tetraodon nigroviridis	60.94	0.00e+00	756.00
IUUC-Tbe-127664	Tupaia belangeri	95.02	0.00e+00	1218.00
IUUC-Ttr-129144	Tursiops truncatus	95.34	0.00e+00	1265.00
IUUC-Vpa-130226	Vicugna pacos	96.54	0.00e+00	1246.00
IUUC-Xtr-132461	Xenopus tropicalis	71.72	0.00e+00	906.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence