iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
PHOSIDA	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	15242647; 15837425; 15916488; 15998872; 16405905; 17082762
ULD/UDP/UBQ/UBQ_PIM	UBQ_PIM	9490418; 10394357; 10471701; 11410533; 11571271; 12052895; 15117949; 15916488; 20061387

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	3.00e-22	76.5	147	185
ULD/UDP/UBQ/UBQ_PIM	1.60e-21	74.5	2	77

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLld 40
           e+++ +e ++eMG+ ree+ +aLraa+nn+++AveyLl 
   Q: 147  ERNETIERIMEMGYQREEVERALRAAFNNPDRAVEYLLM 185
           57999********************************95 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksks 76
           ++lt+k+ k+++++l++++++t+ e K k+a++++++ +q+kLIy+Gk+L+D++t+se+g+kdg+ v+ +v+++ks
   Q: 2    VSLTFKNFKKEKVPLDLEPSNTILETKTKLAQSISCEESQIKLIYSGKVLQDSKTVSECGLKDGDQVVFMVSQKKS 77
           689*********************************************************************9985 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Interacts directly with PNG1.

Protein Sequence
(Fasta)

MVSLTFKNFK KEKVPLDLEP SNTILETKTK LAQSISCEES QIKLIYSGKV LQDSKTVSEC 60
GLKDGDQVVF MVSQKKSTKT KVTEPPIAPE SATTPGRENS TEASPSTDAS AAPAATAPEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTTAGCT TAACCTTTAA AAATTTCAAG AAGGAAAAAG TTCCTTTAGA TCTGGAACCT 60
TCAAACACAA TTTTAGAGAC CAAGACCAAG CTTGCTCAAT CCATTTCTTG TGAAGAATCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR004806--Rad23
IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR015360--XPC-bd

PROSITE

PS50030--UBA
PS50053--UBIQUITIN_2

Pfam

PF00627--UBA
PF00240--ubiquitin
PF09280--XPC-binding

PRINTS

PR01839--RAD23PROTEIN

SMART

SM00727--STI1
SM00165--UBA
SM00213--UBQ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000111--C:nucleotide-excision repair factor 2 complex
GO:0000502--C:proteasome complex
GO:0003684--F:damaged DNA binding
GO:0070628--F:proteasome binding
GO:0030674--F:protein binding, bridging
GO:0043130--F:ubiquitin binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006289--P:nucleotide-excision repair
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006517--P:protein deglycosylation
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

sce:YEL037C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000770	Aegilops tauschii	33.08	2.00e-25	108.00
IUUC-Aml-001195	Ailuropoda melanoleuca	60.78	1.00e-13	68.60
IUUC-Atr-003116	Amborella trichopoda	31.73	2.00e-20	91.30
IUUC-Apl-003371	Anas platyrhynchos	39.84	4.00e-15	73.60
IUUC-Aca-004599	Anolis carolinensis	60.78	1.00e-13	68.90
IUUC-Aly-005694	Arabidopsis lyrata	30.20	5.00e-35	139.00
IUUC-Ath-007157	Arabidopsis thaliana	28.47	9.00e-33	132.00
IUUC-Ago-007830	Ashbya gossypii	41.31	1.00e-71	261.00
IUUC-Acl-008212	Aspergillus clavatus	32.98	1.00e-20	92.00
IUUC-Afl-008605	Aspergillus flavus	34.07	2.00e-24	104.00
IUUC-Afu-008877	Aspergillus fumigatus	32.11	2.00e-21	94.40
IUUC-Ani-009460	Aspergillus nidulans	54.72	1.00e-14	71.60
IUUC-Aor-010032	Aspergillus oryzae	30.43	3.00e-31	127.00
IUUC-Ate-010458	Aspergillus terreus	35.53	2.00e-27	114.00
IUUC-Ame-011704	Astyanax mexicanus	33.58	3.00e-14	69.70
IUUC-Bgr-012056	Blumeria graminis	31.03	2.00e-22	98.20
IUUC-Bta-012922	Bos taurus	34.85	2.00e-22	98.20
IUUC-Bci-013933	Botrytis cinerea	34.38	1.00e-20	92.00
IUUC-Bdi-014355	Brachypodium distachyon	26.38	2.00e-24	104.00
IUUC-Bol-015272	Brassica oleracea	30.69	2.00e-33	134.00
IUUC-Bra-016970	Brassica rapa	31.19	2.00e-33	134.00
IUUC-Cel-018364	Caenorhabditis elegans	35.23	1.00e-14	71.60
IUUC-Cja-018772	Callithrix jacchus	35.25	5.00e-22	96.70
IUUC-Cfa-020683	Canis familiaris	60.78	8.00e-14	69.30
IUUC-Cpo-022145	Cavia porcellus	60.78	8.00e-14	69.30
IUUC-Cre-022810	Chlamydomonas reinhardtii	34.33	2.00e-11	61.20
IUUC-Csa-023714	Chlorocebus sabaeus	34.10	2.00e-22	98.20
IUUC-Cho-024814	Choloepus hoffmanni	63.41	1.00e-10	58.90
IUUC-Cin-025741	Ciona intestinalis	28.74	2.00e-16	77.80
IUUC-Csv-025823	Ciona savignyi	30.46	6.00e-14	68.90
IUUC-Cgl-026495	Colletotrichum gloeosporioides	32.09	1.00e-19	88.20
IUUC-Cne-027056	Cryptococcus neoformans	57.14	5.00e-11	60.10
IUUC-Cme-027260	Cyanidioschyzon merolae	25.73	7.00e-18	82.80
IUUC-Dre-028369	Danio rerio	34.31	9.00e-14	68.90
IUUC-Dno-029543	Dasypus novemcinctus	35.25	1.00e-22	99.00
IUUC-Dor-030358	Dipodomys ordii	32.95	2.00e-20	90.90
IUUC-Dse-031336	Dothistroma septosporum	41.53	3.00e-18	84.00
IUUC-Dme-032027	Drosophila melanogaster	25.61	4.00e-29	120.00
IUUC-Ete-032583	Echinops telfairi	52.08	1.00e-09	55.10
IUUC-Eca-034243	Equus caballus	34.47	1.00e-21	95.10
IUUC-Eeu-034721	Erinaceus europaeus	60.78	3.00e-13	67.40
IUUC-Fca-035679	Felis catus	60.78	1.00e-13	68.90
IUUC-Fal-037148	Ficedula albicollis	37.40	5.00e-15	73.20
IUUC-Fox-037960	Fusarium oxysporum	36.32	1.00e-22	98.20
IUUC-Fso-038107	Fusarium solani	36.98	2.00e-24	104.00
IUUC-Gmo-039080	Gadus morhua	60.87	6.00e-12	62.40
IUUC-Ggr-040116	Gaeumannomyces graminis	40.65	7.00e-16	76.30
IUUC-Gga-040544	Gallus gallus	40.65	3.00e-15	73.90
IUUC-Gac-042298	Gasterosteus aculeatus	34.39	5.00e-14	69.70
IUUC-Gma-043331	Glycine max	27.45	8.00e-28	115.00
IUUC-Ggo-045125	Gorilla gorilla	34.48	3.00e-22	97.40
IUUC-Hsa-046519	Homo sapiens	34.48	3.00e-22	97.40
IUUC-Hvu-047832	Hordeum vulgare	35.02	5.00e-24	103.00
IUUC-Itr-048295	Ictidomys tridecemlineatus	60.78	1.00e-13	68.90
IUUC-Kpa-049314	Komagataella pastoris	34.99	1.00e-52	197.00
IUUC-Lch-050563	Latimeria chalumnae	31.37	2.00e-28	117.00
IUUC-Lpe-051168	Leersia perrieri	29.17	1.00e-29	121.00
IUUC-Loc-051758	Lepisosteus oculatus	36.57	3.00e-18	84.00
IUUC-Lma-053328	Leptosphaeria maculans	38.36	2.00e-08	48.10
IUUC-Laf-054293	Loxodonta africana	33.72	1.00e-21	95.10
IUUC-Mcc-055600	Macaca mulatta	34.10	3.00e-22	97.10
IUUC-Meu-056082	Macropus eugenii	63.41	2.00e-10	58.20
IUUC-Mor-057287	Magnaporthe oryzae	31.94	2.00e-18	84.30
IUUC-Mpo-057609	Magnaporthe poae	40.68	6.00e-15	72.80
IUUC-Mtr-058713	Medicago truncatula	30.00	5.00e-27	113.00
IUUC-Mla-058961	Melampsora laricipopulina	35.71	1.00e-21	95.50
IUUC-Mvi-060220	Microbotryum violaceum	48.98	4.00e-11	60.50
IUUC-Mmr-061771	Microcebus murinus	62.75	2.00e-14	70.90
IUUC-Mdo-062742	Monodelphis domestica	32.28	2.00e-31	127.00
IUUC-Mmu-063258	Mus musculus	34.72	1.00e-24	105.00
IUUC-Mac-065029	Musa acuminata	26.94	1.00e-23	102.00
IUUC-Mpu-066389	Mustela putorius furo	60.78	8.00e-14	69.30
IUUC-Mlu-067999	Myotis lucifugus	60.78	1.00e-13	68.60
IUUC-Nfi-068390	Neosartorya fischeri	30.72	1.00e-15	75.10
IUUC-Ncr-068685	Neurospora crassa	34.98	1.00e-21	95.10
IUUC-Nle-069655	Nomascus leucogenys	34.48	2.00e-22	97.80
IUUC-Ont-072626	Oreochromis niloticus	61.70	3.00e-13	67.40
IUUC-Oan-073572	Ornithorhynchus anatinus	29.11	3.00e-16	77.00
IUUC-Ocu-074831	Oryctolagus cuniculus	60.78	1.00e-13	68.90
IUUC-Oba-074972	Oryza barthii	28.57	1.00e-30	124.00
IUUC-Obr-076909	Oryza brachyantha	27.04	9.00e-26	108.00
IUUC-Ogl-077067	Oryza glaberrima	28.61	1.00e-29	121.00
IUUC-Ogu-078101	Oryza glumaepatula	33.10	5.00e-24	103.00
IUUC-Oin-079203	Oryza indica	28.43	7.00e-26	109.00
IUUC-Olo-080559	Oryza longistaminata	28.12	1.00e-28	118.00
IUUC-Ome-081652	Oryza meridionalis	33.10	5.00e-24	103.00
IUUC-Oni-082812	Oryza nivara	28.82	2.00e-30	124.00
IUUC-Opu-083963	Oryza punctata	28.33	5.00e-29	119.00
IUUC-Oru-084942	Oryza rufipogon	32.57	8.00e-27	112.00
IUUC-Osa-085951	Oryza sativa	28.43	7.00e-26	109.00
IUUC-Ola-086474	Oryzias latipes	38.61	6.00e-14	68.90
IUUC-Olu-087843	Ostreococcus lucimarinus	34.35	1.00e-15	75.10
IUUC-Oga-088023	Otolemur garnettii	33.33	2.00e-22	98.20
IUUC-Oar-089964	Ovis aries	35.25	5.00e-22	96.30
IUUC-Ptr-091165	Pan troglodytes	34.10	4.00e-22	96.70
IUUC-Pan-092009	Papio anubis	33.71	7.00e-21	92.80
IUUC-Psi-093477	Pelodiscus sinensis	60.78	1.00e-13	68.90
IUUC-Pno-095064	Phaeosphaeria nodorum	34.57	1.00e-12	65.50
IUUC-Ppa-095654	Physcomitrella patens	37.78	1.00e-14	72.00
IUUC-Pfo-097385	Poecilia formosa	33.83	9.00e-25	105.00
IUUC-Pab-097868	Pongo abelii	33.72	4.00e-22	96.30
IUUC-Pop-099726	Populus trichocarpa	30.88	4.00e-14	70.10
IUUC-Pca-100652	Procavia capensis	60.78	1.00e-13	68.90
IUUC-Ppe-101830	Prunus persica	29.57	1.00e-25	108.00
IUUC-Pva-102137	Pteropus vampyrus	34.47	4.00e-22	96.70
IUUC-Pgr-103641	Puccinia graminis	30.40	1.00e-35	141.00
IUUC-Ptt-103717	Puccinia triticina	34.44	7.00e-19	86.30
IUUC-Pte-104303	Pyrenophora teres	42.40	2.00e-16	78.20
IUUC-Pyt-104580	Pyrenophora triticirepentis	42.40	2.00e-16	78.20
IUUC-Rno-104844	Rattus norvegicus	35.09	1.00e-25	108.00
IUUC-Sha-107073	Sarcophilus harrisii	60.78	1.00e-13	68.60
IUUC-Sja-107851	Schizosaccharomyces japonicus	39.69	4.00e-36	143.00
IUUC-Spo-108298	Schizosaccharomyces pombe	36.93	3.00e-47	180.00
IUUC-Ssl-108382	Sclerotinia sclerotiorum	34.90	5.00e-23	99.80
IUUC-Smo-109518	Selaginella moellendorffii	26.80	8.00e-12	62.40
IUUC-Sit-109813	Setaria italica	27.41	4.00e-26	110.00
IUUC-Sly-111480	Solanum lycopersicum	31.83	2.00e-32	131.00
IUUC-Stu-112306	Solanum tuberosum	33.82	7.00e-15	72.80
IUUC-Sar-112925	Sorex araneus	65.91	2.00e-12	65.10
IUUC-Sbi-113871	Sorghum bicolor	33.96	2.00e-23	101.00
IUUC-Sre-114894	Sporisorium reilianum	65.12	2.00e-14	71.20
IUUC-Ssc-116329	Sus scrofa	34.85	4.00e-22	97.10
IUUC-Tgu-116918	Taeniopygia guttata	37.40	5.00e-15	73.20
IUUC-Tru-117920	Takifugu rubripes	34.46	1.00e-26	111.00
IUUC-Tsy-118836	Tarsius syrichta	52.08	2.00e-09	55.10
IUUC-Tni-120493	Tetraodon nigroviridis	33.07	2.00e-24	104.00
IUUC-Tca-121661	Theobroma cacao	33.83	1.00e-13	68.90
IUUC-Tre-121911	Trichoderma reesei	38.81	7.00e-30	122.00
IUUC-Tvi-122617	Trichoderma virens	35.60	1.00e-22	98.60
IUUC-Tae-125620	Triticum aestivum	29.33	2.00e-25	107.00
IUUC-Tur-126610	Triticum urartu	33.83	3.00e-26	111.00
IUUC-Tme-127092	Tuber melanosporum	39.49	4.00e-26	110.00
IUUC-Tbe-127603	Tupaia belangeri	36.30	5.00e-14	69.70
IUUC-Ttr-128464	Tursiops truncatus	33.71	8.00e-22	95.90
IUUC-Uma-129484	Ustilago maydis	54.72	2.00e-14	71.60
IUUC-Vda-129946	Verticillium dahliae	39.02	2.00e-15	74.70
IUUC-Vpa-130357	Vicugna pacos	60.78	1.00e-13	68.90
IUUC-Vvi-130842	Vitis vinifera	32.71	2.00e-26	111.00
IUUC-Xtr-132679	Xenopus tropicalis	58.49	1.00e-13	68.90
IUUC-Xma-133647	Xiphophorus maculatus	35.57	3.00e-22	97.40
IUUC-Yli-134615	Yarrowia lipolytica	32.39	3.00e-25	107.00
IUUC-Zma-135678	Zea mays	32.08	4.00e-26	110.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence