iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-010686

Ensembl Protein ID

ENSAMXP00000002742.1

UniProt Accession

W5K581; W5K581_ASTMX

Genbank Protein ID

ENSAMXP00000002742

Protein Name

Presenilin

Genbank Nucleotide ID

APWO01119950

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000002667.1	ENSAMXT00000002742.1	ENSAMXP00000002742.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	1.40e-06	28.4	231	259

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantg 30
           +eta+e++++iFP+l+ys+++ +++ +++
   Q: 231  VETAQERNEPIFPALIYSSTMIWMVGMAN 259
           89**********************99876 PP

Organism

Astyanax mexicanus

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

DTEAGHAARG GVAAPRERDS GPIPDGEDEE LTVKYGAKHV IMLFVPVTLC MVVVVATIKS 60
VSFYTEKNGQ QLIYTPFTED TNSVGQRLLN SVLNTIIMIS VIVVMTIFLV VLYKYRCYKF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACTAAATAC CACAAAAAAT ATTAATATGG CACCAATTTT TTTTTTTTTA ATCTTCTTAG 60
CGACGGCATG CTAACTCCGA CACGGAGGCG GGACACGCTG CCCGCGGGGG TGTCGCAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0034205--P:beta-amyloid formation
GO:0007420--P:brain development
GO:0035556--P:intracellular signal transduction
GO:0030318--P:melanocyte differentiation
GO:0022008--P:neurogenesis
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing
GO:0061053--P:somite development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	29.60	5.00e-23	103.00
IUUC-Aml-002356	Ailuropoda melanoleuca	72.82	6.00e-116	410.00
IUUC-Atr-003039	Amborella trichopoda	31.07	2.00e-36	147.00
IUUC-Apl-003959	Anas platyrhynchos	75.90	2.00e-140	492.00
IUUC-Aca-005160	Anolis carolinensis	74.34	1.00e-152	532.00
IUUC-Aly-005455	Arabidopsis lyrata	41.55	4.00e-17	82.40
IUUC-Ath-006730	Arabidopsis thaliana	31.63	1.00e-18	87.40
IUUC-Bta-013097	Bos taurus	79.42	3.00e-140	491.00
IUUC-Bol-015841	Brassica oleracea	31.67	2.00e-30	127.00
IUUC-Bra-017580	Brassica rapa	51.28	1.00e-18	87.00
IUUC-Cel-018553	Caenorhabditis elegans	51.87	5.00e-96	344.00
IUUC-Cja-018824	Callithrix jacchus	78.63	7.00e-137	480.00
IUUC-Cfa-020253	Canis familiaris	76.62	1.00e-141	496.00
IUUC-Cpo-021401	Cavia porcellus	80.21	7.00e-141	493.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	31.80	9.00e-29	121.00
IUUC-Csa-023369	Chlorocebus sabaeus	80.21	1.00e-141	496.00
IUUC-Cin-025780	Ciona intestinalis	61.85	3.00e-121	428.00
IUUC-Csv-025967	Ciona savignyi	62.62	1.00e-123	436.00
IUUC-Dre-028526	Danio rerio	82.95	3.00e-163	568.00
IUUC-Dor-031127	Dipodomys ordii	78.68	3.00e-139	488.00
IUUC-Dme-031929	Drosophila melanogaster	54.42	7.00e-110	390.00
IUUC-Ete-033081	Echinops telfairi	66.08	4.00e-67	248.00
IUUC-Eca-034387	Equus caballus	80.74	1.00e-137	483.00
IUUC-Fca-035396	Felis catus	79.37	2.00e-149	521.00
IUUC-Fal-037457	Ficedula albicollis	79.57	9.00e-139	486.00
IUUC-Gmo-038550	Gadus morhua	74.23	8.00e-143	499.00
IUUC-Gga-040706	Gallus gallus	80.90	7.00e-142	497.00
IUUC-Gac-042511	Gasterosteus aculeatus	78.77	3.00e-142	498.00
IUUC-Gma-043822	Glycine max	35.00	4.00e-22	99.00
IUUC-Ggo-045338	Gorilla gorilla	80.21	2.00e-141	495.00
IUUC-Hsa-046455	Homo sapiens	80.21	2.00e-141	495.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	80.21	2.00e-141	495.00
IUUC-Lch-049638	Latimeria chalumnae	69.93	4.00e-133	468.00
IUUC-Lpe-051132	Leersia perrieri	34.78	7.00e-17	81.60
IUUC-Loc-052427	Lepisosteus oculatus	80.54	9.00e-161	559.00
IUUC-Laf-053758	Loxodonta africana	79.43	4.00e-151	527.00
IUUC-Mcc-054755	Macaca mulatta	80.21	3.00e-141	495.00
IUUC-Mtr-058392	Medicago truncatula	32.63	2.00e-30	126.00
IUUC-Mmr-060890	Microcebus murinus	80.21	2.00e-141	495.00
IUUC-Mdo-062197	Monodelphis domestica	79.79	5.00e-144	504.00
IUUC-Mmu-063823	Mus musculus	79.95	2.00e-142	499.00
IUUC-Mac-064858	Musa acuminata	40.45	7.00e-21	94.40
IUUC-Mpu-066181	Mustela putorius furo	80.21	2.00e-141	495.00
IUUC-Nle-069596	Nomascus leucogenys	78.46	1.00e-127	449.00
IUUC-Opr-070344	Ochotona princeps	78.39	8.00e-145	506.00
IUUC-Ont-071867	Oreochromis niloticus	84.37	4.00e-145	507.00
IUUC-Oan-073378	Ornithorhynchus anatinus	78.09	3.00e-129	454.00
IUUC-Ocu-074652	Oryctolagus cuniculus	81.05	1.00e-142	499.00
IUUC-Oba-075256	Oryza barthii	55.45	6.00e-17	82.00
IUUC-Obr-076302	Oryza brachyantha	34.78	2.00e-16	80.90
IUUC-Ogu-078570	Oryza glumaepatula	55.45	1.00e-16	81.30
IUUC-Oin-079244	Oryza indica	34.17	2.00e-32	133.00
IUUC-Olo-080484	Oryza longistaminata	56.44	2.00e-17	82.80
IUUC-Ome-081814	Oryza meridionalis	56.44	2.00e-17	83.60
IUUC-Oni-082057	Oryza nivara	34.17	2.00e-32	132.00
IUUC-Oru-084618	Oryza rufipogon	55.45	1.00e-16	81.30
IUUC-Ola-086707	Oryzias latipes	82.47	2.00e-110	392.00
IUUC-Olu-087811	Ostreococcus lucimarinus	36.78	9.00e-44	170.00
IUUC-Oga-088560	Otolemur garnettii	80.58	1.00e-142	499.00
IUUC-Oar-089200	Ovis aries	79.42	2.00e-140	492.00
IUUC-Ptr-090569	Pan troglodytes	80.21	2.00e-141	495.00
IUUC-Pan-091742	Papio anubis	80.21	2.00e-141	495.00
IUUC-Pma-094612	Petromyzon marinus	77.63	4.00e-128	451.00
IUUC-Ppa-095431	Physcomitrella patens	33.80	2.00e-27	117.00
IUUC-Pab-098531	Pongo abelii	80.21	1.00e-141	496.00
IUUC-Pop-099661	Populus trichocarpa	34.86	2.00e-37	149.00
IUUC-Pca-101120	Procavia capensis	78.10	1.00e-135	476.00
IUUC-Ppe-101495	Prunus persica	30.16	5.00e-36	145.00
IUUC-Pva-102934	Pteropus vampyrus	73.70	8.00e-138	483.00
IUUC-Rno-106052	Rattus norvegicus	80.21	1.00e-146	512.00
IUUC-Sha-106876	Sarcophilus harrisii	77.66	2.00e-143	501.00
IUUC-Sly-110865	Solanum lycopersicum	55.56	8.00e-07	45.40
IUUC-Stu-112433	Solanum tuberosum	32.94	3.00e-30	125.00
IUUC-Sbi-114305	Sorghum bicolor	32.04	2.00e-27	117.00
IUUC-Ssc-115380	Sus scrofa	80.21	6.00e-147	513.00
IUUC-Tgu-117280	Taeniopygia guttata	79.41	1.00e-139	489.00
IUUC-Tca-121865	Theobroma cacao	31.17	4.00e-37	149.00
IUUC-Tae-123984	Triticum aestivum	30.13	4.00e-26	112.00
IUUC-Tbe-127632	Tupaia belangeri	86.48	3.00e-117	414.00
IUUC-Ttr-129008	Tursiops truncatus	79.42	1.00e-138	486.00
IUUC-Vvi-131312	Vitis vinifera	32.81	8.00e-33	134.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence