iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-096709

Ensembl Protein ID

ENSPFOP00000025218.1

UniProt Accession

A0A096M1C7; A0A096M1C7_POEFO

Genbank Protein ID

ENSPFOP00000025218

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AYCK01007415

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000003126.2	ENSPFOT00000026080.1	ENSPFOP00000025218.1
ENSPFOG00000003126.2	ENSPFOT00000003415.2	ENSPFOP00000003409.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.80e-130	433.9	565	897

Active Site

Position(s)	Description	Evidence
866	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 565  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 652
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+kk +l+dle++dpe+y+s++++ken   +++++g++l f ++ eilg+++++ Lk+gGe++ Vt+e keeY++l+++
   Q: 653  GFTLPFYKRMLDKKPTLKDLESIDPEFYNSIMWVKEN---NLKDCGVELYFAQDMEILGKVSSHALKEGGEDELVTEETKEEYISLLTD 738
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev+ple+l++F+e+elel++cG++eid+ d++k+t y++ yt++s++i+wFw+v++e+++e+r ++LqFv
   Q: 739  WRFTRGVEEQTKAFLDGFNEVVPLEWLRYFDEKELELMLCGMQEIDLADWQKNTIYRH-YTKNSKQIHWFWQVVKEMDNEKRIRLLQFV 826
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGf el     p++f+i + +++++lP+s+TCfn+L+LP+Y s e+l+ekLl+Aieet+gF++
   Q: 827  TGTCRLPVGGFTELIgsngPQKFCIDRVGKETWLPRSHTCFNRLDLPPYRSLEQLREKLLFAIEETEGFGQ 897
           *********************************************************************96 PP

Organism

Poecilia formosa

Protein Sequence
(Fasta)

MAAASVTRPG STQTPEKSQL ILKVVSAKPQ SPKLPNRHSR LSSFVEVTAD GLTSETKKTG 60
KRTGHLELQW NEDLTLNVTP QSHLDLKLWS CHTLRKELLG SATIDLLDTL RTHDGKMENV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTGTGATG TCATGGCGGC TGCCAGCGTG ACCCGACCTG GCAGTACCCA GACCCCCGAA 60
AAGTCTCAGT TGATCCTGAA AGGTAAAGAG CTGATTAGCA TGTAAAGTGT TCTGTTTTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	73.22	0.00e+00	1308.00
IUUC-Apl-003912	Anas platyrhynchos	85.57	0.00e+00	1060.00
IUUC-Aca-004291	Anolis carolinensis	71.85	0.00e+00	1291.00
IUUC-Bta-013231	Bos taurus	90.48	0.00e+00	1113.00
IUUC-Cja-019455	Callithrix jacchus	72.13	0.00e+00	1309.00
IUUC-Cfa-021017	Canis familiaris	90.83	0.00e+00	1117.00
IUUC-Cpo-021988	Cavia porcellus	73.03	0.00e+00	1310.00
IUUC-Csa-023549	Chlorocebus sabaeus	71.72	0.00e+00	1318.00
IUUC-Dre-028513	Danio rerio	78.31	0.00e+00	1390.00
IUUC-Dno-028976	Dasypus novemcinctus	71.86	0.00e+00	1319.00
IUUC-Dor-030176	Dipodomys ordii	90.12	0.00e+00	1105.00
IUUC-Eca-033949	Equus caballus	72.95	0.00e+00	1303.00
IUUC-Eeu-034529	Erinaceus europaeus	67.12	0.00e+00	1064.00
IUUC-Fca-036236	Felis catus	72.49	0.00e+00	1328.00
IUUC-Fal-036948	Ficedula albicollis	90.91	0.00e+00	1120.00
IUUC-Gmo-038842	Gadus morhua	92.77	0.00e+00	1101.00
IUUC-Gga-040617	Gallus gallus	71.86	0.00e+00	1279.00
IUUC-Gac-041338	Gasterosteus aculeatus	93.85	0.00e+00	1139.00
IUUC-Ggo-045278	Gorilla gorilla	71.91	0.00e+00	1321.00
IUUC-Hsa-046148	Homo sapiens	72.02	0.00e+00	1323.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	90.30	0.00e+00	1041.00
IUUC-Lch-050663	Latimeria chalumnae	72.87	0.00e+00	1330.00
IUUC-Loc-052604	Lepisosteus oculatus	76.01	0.00e+00	1344.00
IUUC-Laf-053944	Loxodonta africana	73.36	0.00e+00	1320.00
IUUC-Mcc-055655	Macaca mulatta	71.48	0.00e+00	1316.00
IUUC-Meu-055953	Macropus eugenii	75.25	0.00e+00	960.00
IUUC-Mga-060190	Meleagris gallopavo	71.54	0.00e+00	1282.00
IUUC-Mmr-060896	Microcebus murinus	71.32	0.00e+00	1303.00
IUUC-Mdo-062536	Monodelphis domestica	73.61	0.00e+00	1333.00
IUUC-Mmu-064017	Mus musculus	71.89	0.00e+00	1316.00
IUUC-Mpu-066608	Mustela putorius furo	71.21	0.00e+00	1254.00
IUUC-Mlu-067623	Myotis lucifugus	70.42	0.00e+00	1253.00
IUUC-Nle-069496	Nomascus leucogenys	70.27	0.00e+00	1275.00
IUUC-Opr-071054	Ochotona princeps	89.95	0.00e+00	1102.00
IUUC-Ont-071279	Oreochromis niloticus	88.08	0.00e+00	1526.00
IUUC-Oan-073512	Ornithorhynchus anatinus	70.30	0.00e+00	1258.00
IUUC-Ocu-074271	Oryctolagus cuniculus	72.02	0.00e+00	1292.00
IUUC-Ola-087237	Oryzias latipes	82.14	0.00e+00	1451.00
IUUC-Oga-088164	Otolemur garnettii	72.81	0.00e+00	1313.00
IUUC-Oar-089698	Ovis aries	90.48	0.00e+00	1113.00
IUUC-Ptr-091306	Pan troglodytes	71.15	0.00e+00	1297.00
IUUC-Pan-092814	Papio anubis	69.00	0.00e+00	1242.00
IUUC-Pab-098494	Pongo abelii	72.98	0.00e+00	1285.00
IUUC-Pca-100596	Procavia capensis	65.25	0.00e+00	1107.00
IUUC-Pva-103154	Pteropus vampyrus	86.01	0.00e+00	1071.00
IUUC-Rno-104954	Rattus norvegicus	74.27	0.00e+00	1174.00
IUUC-Sha-106781	Sarcophilus harrisii	73.11	0.00e+00	1332.00
IUUC-Ssc-116307	Sus scrofa	66.99	0.00e+00	1146.00
IUUC-Tgu-116530	Taeniopygia guttata	85.01	0.00e+00	1017.00
IUUC-Tru-118287	Takifugu rubripes	79.79	0.00e+00	1429.00
IUUC-Tni-120801	Tetraodon nigroviridis	80.77	0.00e+00	1356.00
IUUC-Tbe-127793	Tupaia belangeri	63.96	0.00e+00	1099.00
IUUC-Ttr-128275	Tursiops truncatus	90.48	0.00e+00	1117.00
IUUC-Xtr-132866	Xenopus tropicalis	84.60	0.00e+00	1099.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence