iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-055317

Ensembl Protein ID

ENSMMUP00000000156.3

UniProt Accession

F7H8A7; F7H8A7_MACMU

Genbank Protein ID

ENSMMUP00000000156

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

JSUE03004589

Gene Name

HCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000000117.3	ENSMMUT00000000168.3	ENSMMUP00000000156.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	8.00e-16	58.9	60	115

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            v +lydyea + ++L+++kGd++ v+   e++++W+k+ + ++ k+G +P+n+v++++
   Q: 60   IVVALYDYEAIHHEDLSFQKGDQMVVL---EESGEWWKARSLATRKEGYIPSNYVARVD 115
           689************************...99*************************97 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MGCMKSKFLQ SGGNTFSKTE TSANPHCPVY VPDPTSTIKP GPNSNNRNTP GIGEGSEDII 60
VVALYDYEAI HHEDLSFQKG DQMVVLEESG EWWKARSLAT RKEGYIPSNY VARVDSLETE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGGCATGG GAGCGGGTGC TGGGGTTCTT AGACGGCGAG GGCTTCGAAA TCCCACGGGG 60
CCCAGGGGTG GCATTTGGGA TCCTTCGGAG ACTGCGGTAG GACGCTGGGC GGTGGGATGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

mcc:715723

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000140	Aegilops tauschii	30.62	1.00e-21	98.60
IUUC-Aml-001284	Ailuropoda melanoleuca	91.30	0.00e+00	952.00
IUUC-Apl-003285	Anas platyrhynchos	78.78	0.00e+00	813.00
IUUC-Aca-004724	Anolis carolinensis	78.15	0.00e+00	788.00
IUUC-Ame-011954	Astyanax mexicanus	75.69	0.00e+00	773.00
IUUC-Bta-013060	Bos taurus	91.67	0.00e+00	966.00
IUUC-Bdi-014122	Brachypodium distachyon	31.40	9.00e-22	99.00
IUUC-Cja-019817	Callithrix jacchus	95.84	0.00e+00	982.00
IUUC-Cfa-020511	Canis familiaris	91.87	0.00e+00	963.00
IUUC-Cpo-022538	Cavia porcellus	90.30	0.00e+00	952.00
IUUC-Csa-024143	Chlorocebus sabaeus	99.40	0.00e+00	1046.00
IUUC-Dre-028157	Danio rerio	76.88	0.00e+00	799.00
IUUC-Dno-029761	Dasypus novemcinctus	89.50	0.00e+00	936.00
IUUC-Eca-034090	Equus caballus	88.69	0.00e+00	924.00
IUUC-Fca-035937	Felis catus	89.48	0.00e+00	905.00
IUUC-Fal-036624	Ficedula albicollis	77.84	0.00e+00	806.00
IUUC-Gmo-039009	Gadus morhua	73.02	0.00e+00	762.00
IUUC-Gga-040296	Gallus gallus	79.11	0.00e+00	785.00
IUUC-Gac-042362	Gasterosteus aculeatus	81.84	0.00e+00	784.00
IUUC-Ggo-044570	Gorilla gorilla	98.02	0.00e+00	1020.00
IUUC-Hsa-046378	Homo sapiens	98.02	0.00e+00	1033.00
IUUC-Itr-048695	Ictidomys tridecemlineatus	90.50	0.00e+00	944.00
IUUC-Loc-052904	Lepisosteus oculatus	79.13	0.00e+00	829.00
IUUC-Laf-053654	Loxodonta africana	89.68	0.00e+00	937.00
IUUC-Mga-060194	Meleagris gallopavo	81.51	0.00e+00	772.00
IUUC-Mmr-061510	Microcebus murinus	90.50	0.00e+00	947.00
IUUC-Mdo-062035	Monodelphis domestica	84.16	0.00e+00	884.00
IUUC-Mmu-064037	Mus musculus	90.48	0.00e+00	953.00
IUUC-Mpu-066874	Mustela putorius furo	91.29	0.00e+00	958.00
IUUC-Mlu-068202	Myotis lucifugus	88.29	0.00e+00	907.00
IUUC-Nle-069222	Nomascus leucogenys	98.41	0.00e+00	1026.00
IUUC-Opr-070705	Ochotona princeps	87.52	0.00e+00	928.00
IUUC-Ont-072347	Oreochromis niloticus	83.18	0.00e+00	773.00
IUUC-Ocu-074490	Oryctolagus cuniculus	89.68	0.00e+00	937.00
IUUC-Ola-086521	Oryzias latipes	82.06	0.00e+00	782.00
IUUC-Oga-088153	Otolemur garnettii	92.08	0.00e+00	961.00
IUUC-Oar-090184	Ovis aries	91.52	0.00e+00	962.00
IUUC-Ptr-090505	Pan troglodytes	94.26	0.00e+00	969.00
IUUC-Pan-092260	Papio anubis	99.60	0.00e+00	1053.00
IUUC-Pma-094311	Petromyzon marinus	68.67	0.00e+00	743.00
IUUC-Pfo-096566	Poecilia formosa	76.33	0.00e+00	800.00
IUUC-Pab-097908	Pongo abelii	77.62	0.00e+00	765.00
IUUC-Pva-103021	Pteropus vampyrus	91.49	0.00e+00	954.00
IUUC-Rno-105309	Rattus norvegicus	90.48	0.00e+00	951.00
IUUC-Sha-107099	Sarcophilus harrisii	82.85	0.00e+00	879.00
IUUC-Tgu-116912	Taeniopygia guttata	78.39	0.00e+00	802.00
IUUC-Tru-118449	Takifugu rubripes	82.02	0.00e+00	767.00
IUUC-Tae-123706	Triticum aestivum	31.01	3.00e-22	100.00
IUUC-Tur-126022	Triticum urartu	31.01	3.00e-22	100.00
IUUC-Tbe-128144	Tupaia belangeri	87.11	0.00e+00	805.00
IUUC-Xtr-132224	Xenopus tropicalis	71.81	0.00e+00	697.00
IUUC-Xma-133902	Xiphophorus maculatus	76.24	0.00e+00	799.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence