iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-134250

Ensembl Protein ID

ENSXMAP00000009942.1

UniProt Accession

M4A648; M4A648_XIPMA

Genbank Protein ID

ENSXMAP00000009942

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGAJ01004824

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000009868.1	ENSXMAT00000009956.1	ENSXMAP00000009942.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.80e-96	322.8	724	1048

Active Site

Position(s)	Description	Evidence
1017	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
            dlkk l+v f gEe++d+gGvt+ef+ ll+kel +p +g+f++ ++++  ++ ++        + ++F+++G+++g+a++++ ++d
   Q: 724  VDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLDPVYGMFTHYKDSNLLWFSDKCFV-----EQNWFHLIGIVCGLAIYNSTVVD 805
           589****************************************9999999999888665.....579******************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           l+++ ++yk+ll+++ sl+d++e+ p+ ++sl+++++++  d+ee+ + l+f ++ e++g t+++eL+pgGe+i V ++N++e+v++
   Q: 806  LHFPLALYKKLLDVSPSLDDFKELSPTEARSLQQLLDYEGGDVEET-FVLSFAITRENYGMTEVKELIPGGESIAVDKNNRKEFVEA 891
           **************************************99999997.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           ++ y + +++ eq+ af++Gf +v+  e+lslF+++el  ++ G++++++e+++k++ ykg+yt+++p+++ Fwev++ef  e++k+
   Q: 892  YLRYVFSDSVSEQYSAFSAGFLKVCGGEILSLFQPSELMAMVVGNNNYNWEEMEKNAVYKGEYTATHPTVRLFWEVFHEFPLEKKKQ 978
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           fL F+Tgs+r+P+ G+++l+   +vi+   a+++ lP ++TC+n+L++P+Y++ke+l+++L+ A+e+ +gF+l
   Q: 979  FLLFLTGSDRIPIHGMESLR---IVIQStTAEEHYLPVAHTCYNLLDMPRYQTKETLRRRLTQAVEQYEGFSL 1048
           ********************...8888867777**************************************97 PP

Organism

Xiphophorus maculatus

Protein Sequence
(Fasta)

MLCWGNARDG QLGIGAERNP AFEPRSCHVF SGRGLKEVVC GGQHTLFLLH DGSVYTCGSN 60
SCGQLGHNRD GTSPELVGAL DTQKITMVSC GRAHSMAINE QGQVFAWGAG EGGQLGLGTV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGCGGACCA ATCACATCAT TCCTACCTCT GAGGCGTTTG GTGACGTAAG CAGCTATAGC 60
ACTTCCTCGT TTGTTTTCTG AGTTGCACAC CAGAAGCCAA ACGCCCCTTC CTCAACATGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001673	Ailuropoda melanoleuca	65.53	0.00e+00	1363.00
IUUC-Apl-003535	Anas platyrhynchos	65.81	0.00e+00	1379.00
IUUC-Aca-005223	Anolis carolinensis	64.61	0.00e+00	1358.00
IUUC-Ame-010816	Astyanax mexicanus	77.89	0.00e+00	1393.00
IUUC-Bta-013373	Bos taurus	65.53	0.00e+00	1374.00
IUUC-Cja-019609	Callithrix jacchus	65.53	0.00e+00	1362.00
IUUC-Cfa-021071	Canis familiaris	65.34	0.00e+00	1360.00
IUUC-Cpo-021548	Cavia porcellus	65.43	0.00e+00	1361.00
IUUC-Csa-023987	Chlorocebus sabaeus	65.53	0.00e+00	1362.00
IUUC-Cho-024325	Choloepus hoffmanni	71.90	0.00e+00	876.00
IUUC-Dre-027472	Danio rerio	78.78	0.00e+00	1689.00
IUUC-Dno-029241	Dasypus novemcinctus	64.64	0.00e+00	1342.00
IUUC-Dor-030672	Dipodomys ordii	55.42	0.00e+00	652.00
IUUC-Ete-032642	Echinops telfairi	63.63	0.00e+00	1276.00
IUUC-Eca-033646	Equus caballus	65.24	0.00e+00	1357.00
IUUC-Eeu-035098	Erinaceus europaeus	61.82	0.00e+00	829.00
IUUC-Fal-036952	Ficedula albicollis	65.91	0.00e+00	1381.00
IUUC-Gmo-039297	Gadus morhua	78.12	0.00e+00	1638.00
IUUC-Gga-040591	Gallus gallus	65.43	0.00e+00	1371.00
IUUC-Gac-041741	Gasterosteus aculeatus	88.86	0.00e+00	1930.00
IUUC-Gma-043616	Glycine max	34.80	2.00e-51	196.00
IUUC-Ggo-044769	Gorilla gorilla	65.46	0.00e+00	1359.00
IUUC-Hsa-046066	Homo sapiens	65.43	0.00e+00	1361.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	65.46	0.00e+00	1363.00
IUUC-Lch-050301	Latimeria chalumnae	66.00	0.00e+00	1447.00
IUUC-Loc-052803	Lepisosteus oculatus	75.23	0.00e+00	1659.00
IUUC-Laf-053364	Loxodonta africana	65.81	0.00e+00	1368.00
IUUC-Mcc-054930	Macaca mulatta	65.53	0.00e+00	1362.00
IUUC-Meu-056274	Macropus eugenii	53.66	1.00e-158	554.00
IUUC-Mga-059563	Meleagris gallopavo	65.81	0.00e+00	1379.00
IUUC-Mmr-060792	Microcebus murinus	64.96	0.00e+00	1341.00
IUUC-Mdo-062195	Monodelphis domestica	65.78	0.00e+00	1371.00
IUUC-Mmu-063855	Mus musculus	65.15	0.00e+00	1365.00
IUUC-Mpu-066308	Mustela putorius furo	65.43	0.00e+00	1363.00
IUUC-Mlu-066927	Myotis lucifugus	65.15	0.00e+00	1362.00
IUUC-Nle-070090	Nomascus leucogenys	65.53	0.00e+00	1363.00
IUUC-Opr-070891	Ochotona princeps	58.21	0.00e+00	1149.00
IUUC-Ont-072201	Oreochromis niloticus	88.90	0.00e+00	1924.00
IUUC-Ocu-074770	Oryctolagus cuniculus	65.43	0.00e+00	1363.00
IUUC-Ola-086550	Oryzias latipes	86.16	0.00e+00	1887.00
IUUC-Oga-088831	Otolemur garnettii	65.15	0.00e+00	1351.00
IUUC-Oar-090449	Ovis aries	65.62	0.00e+00	1370.00
IUUC-Pan-092135	Papio anubis	65.56	0.00e+00	1363.00
IUUC-Psi-093832	Pelodiscus sinensis	65.15	0.00e+00	1389.00
IUUC-Pfo-097268	Poecilia formosa	98.67	0.00e+00	2097.00
IUUC-Pab-098249	Pongo abelii	65.34	0.00e+00	1361.00
IUUC-Pca-100855	Procavia capensis	58.56	0.00e+00	867.00
IUUC-Pva-102506	Pteropus vampyrus	59.77	0.00e+00	1172.00
IUUC-Rno-105242	Rattus norvegicus	65.43	0.00e+00	1407.00
IUUC-Sar-113612	Sorex araneus	72.59	3.00e-159	555.00
IUUC-Ssc-115473	Sus scrofa	65.53	0.00e+00	1364.00
IUUC-Tgu-116974	Taeniopygia guttata	65.94	0.00e+00	1359.00
IUUC-Tru-118077	Takifugu rubripes	83.82	0.00e+00	1812.00
IUUC-Tsy-119619	Tarsius syrichta	55.50	0.00e+00	1151.00
IUUC-Tni-120807	Tetraodon nigroviridis	84.69	0.00e+00	1829.00
IUUC-Tbe-127640	Tupaia belangeri	63.27	0.00e+00	1283.00
IUUC-Ttr-129172	Tursiops truncatus	65.15	0.00e+00	1353.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence