iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBA	7.90e-19	67.5	298	330
ULD/UDP/UBQ/UBQ_PIM	2.40e-16	59.8	14	98

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 7    leqlveMGFdreealqaLraannnleaAveyLl 39
           +  l+eMGFd++e++ aLr +nn+ +aA+e+Ll
   Q: 298  VISLMEMGFDEKEVIDALRVNNNQQNAACEWLL 330
           5679****************************9 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesg...vp....peqqkLIyaG..kiLkDdttLselgikdgsvvhlvvkksks 76
           ++l++++ +g+e+ +e++ed++ve+lKe + k+     ++    ++++kLI+a+  ++L+D++t+ e +i+d++v++l++k+++s
   Q: 14   LRLHICAADGSEWLEEATEDTSVEKLKESCLKHGAhgsLEdpknVTHHKLIHAAseRVLSDSKTILEENIQDQDVLLLIKKRAPS 98
           589******************************66767447778*************************************9875 PP

Organism

Rattus norvegicus

Functional Description
(View)

Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle (By similarity).

Protein Sequence
(Fasta)

MFVQEEKIFA GKVLRLHICA ADGSEWLEEA TEDTSVEKLK ESCLKHGAHG SLEDPKNVTH 60
HKLIHAASER VLSDSKTILE ENIQDQDVLL LIKKRAPSPI PKMADVSAEE KKKQEQKAPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGCTCCTGC CCCTTCAGTG ACGGGCGGCC AAGCTGACAG GAGCCGGGGC GGGGCGGCGG 60
CGGCCAGCGA AGGAGCGCGC GGCGGCCCGG CCCCGCCCCT GGTCCTCCCG CCAGCCCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom

PROSITE

PS50030--UBA

Pfam

PF00627--UBA

SMART

SM00727--STI1
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0016567--P:protein ubiquitination

KEGG

rno:362087

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002260	Ailuropoda melanoleuca	85.18	3.00e-164	570.00
IUUC-Apl-003707	Anas platyrhynchos	81.73	3.00e-133	468.00
IUUC-Aca-004298	Anolis carolinensis	74.47	7.00e-16	74.70
IUUC-Ame-010990	Astyanax mexicanus	75.35	4.00e-153	534.00
IUUC-Bta-012350	Bos taurus	83.62	3.00e-179	620.00
IUUC-Cja-019641	Callithrix jacchus	80.94	4.00e-142	497.00
IUUC-Cfa-020817	Canis familiaris	87.10	0.00e+00	663.00
IUUC-Cpo-022281	Cavia porcellus	87.25	2.00e-179	622.00
IUUC-Csa-023235	Chlorocebus sabaeus	87.53	0.00e+00	660.00
IUUC-Cho-024473	Choloepus hoffmanni	84.42	2.00e-131	461.00
IUUC-Cin-025423	Ciona intestinalis	30.81	2.00e-43	169.00
IUUC-Csv-026357	Ciona savignyi	31.12	2.00e-35	143.00
IUUC-Dre-028611	Danio rerio	76.87	7.00e-163	566.00
IUUC-Dno-029898	Dasypus novemcinctus	84.38	6.00e-160	556.00
IUUC-Dor-030157	Dipodomys ordii	89.78	3.00e-157	547.00
IUUC-Dme-032139	Drosophila melanogaster	28.70	3.00e-22	100.00
IUUC-Ete-032241	Echinops telfairi	78.50	5.00e-35	141.00
IUUC-Eca-033465	Equus caballus	86.63	0.00e+00	637.00
IUUC-Eeu-034757	Erinaceus europaeus	89.40	3.00e-93	335.00
IUUC-Fca-035878	Felis catus	81.22	1.00e-166	578.00
IUUC-Fal-037270	Ficedula albicollis	80.65	8.00e-152	529.00
IUUC-Gmo-038625	Gadus morhua	77.62	2.00e-167	581.00
IUUC-Gga-041270	Gallus gallus	79.71	3.00e-174	604.00
IUUC-Gac-041881	Gasterosteus aculeatus	76.39	2.00e-165	575.00
IUUC-Ggo-045434	Gorilla gorilla	87.29	0.00e+00	657.00
IUUC-Hsa-046531	Homo sapiens	87.53	0.00e+00	657.00
IUUC-Itr-048688	Ictidomys tridecemlineatus	88.95	1.00e-163	568.00
IUUC-Lch-050375	Latimeria chalumnae	79.95	4.00e-166	577.00
IUUC-Loc-052806	Lepisosteus oculatus	78.23	9.00e-162	562.00
IUUC-Laf-054021	Loxodonta africana	83.37	0.00e+00	661.00
IUUC-Mcc-054798	Macaca mulatta	85.40	0.00e+00	628.00
IUUC-Meu-056193	Macropus eugenii	61.61	3.00e-102	365.00
IUUC-Mga-059853	Meleagris gallopavo	75.18	1.00e-156	545.00
IUUC-Mmr-061109	Microcebus murinus	87.25	0.00e+00	652.00
IUUC-Mdo-062799	Monodelphis domestica	81.91	3.00e-168	584.00
IUUC-Mmu-063873	Mus musculus	98.53	0.00e+00	677.00
IUUC-Mpu-066105	Mustela putorius furo	84.31	2.00e-122	431.00
IUUC-Mlu-067997	Myotis lucifugus	84.82	5.00e-99	353.00
IUUC-Nle-070022	Nomascus leucogenys	87.53	0.00e+00	659.00
IUUC-Ont-072395	Oreochromis niloticus	76.83	1.00e-162	565.00
IUUC-Oan-073631	Ornithorhynchus anatinus	83.38	6.00e-143	500.00
IUUC-Ola-086861	Oryzias latipes	75.82	1.00e-73	270.00
IUUC-Oga-088505	Otolemur garnettii	85.33	0.00e+00	656.00
IUUC-Oar-090395	Ovis aries	83.13	2.00e-180	625.00
IUUC-Ptr-091265	Pan troglodytes	86.80	0.00e+00	646.00
IUUC-Pan-091760	Papio anubis	87.53	0.00e+00	660.00
IUUC-Psi-092977	Pelodiscus sinensis	81.48	1.00e-118	419.00
IUUC-Pfo-097495	Poecilia formosa	77.78	8.00e-97	347.00
IUUC-Pab-097995	Pongo abelii	85.41	6.00e-164	570.00
IUUC-Pca-100468	Procavia capensis	64.64	2.00e-103	369.00
IUUC-Pva-102145	Pteropus vampyrus	85.82	8.00e-179	619.00
IUUC-Sha-106496	Sarcophilus harrisii	83.62	1.00e-164	572.00
IUUC-Tgu-116846	Taeniopygia guttata	79.85	6.00e-163	566.00
IUUC-Tru-118687	Takifugu rubripes	75.30	3.00e-162	564.00
IUUC-Tni-119838	Tetraodon nigroviridis	77.26	1.00e-162	565.00
IUUC-Tbe-127323	Tupaia belangeri	68.52	6.00e-107	380.00
IUUC-Ttr-129174	Tursiops truncatus	71.15	9.00e-143	499.00
IUUC-Vpa-130792	Vicugna pacos	71.77	2.00e-125	441.00
IUUC-Xtr-132912	Xenopus tropicalis	73.76	7.00e-128	450.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence