iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012391

UUCD1 version

UUC-BoT-00519

Ensembl Protein ID

ENSBTAP00000010457.5

UniProt Accession

F1MNN4; Q0VCX6; FBXW7_BOVIN

Genbank Protein ID

AAI19947.1

Protein Name

F-box/WD repeat-containing protein 7; F-box and WD-40 domain-containing protein 7

Genbank Nucleotide ID

DAAA02044177

Gene Name

FBXW7; FBW7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000007953.5	ENSBTAT00000010457.5	ENSBTAP00000010457.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.20e-61	199.5	543	576
UBD/Beta-Prp	2.50e-102	342.2	294	576

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H++ vtcl+f+ ++++++sdDgt+k+WDl+tg  
   Q: 543  HQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEF 576
           9*********449******************976 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk 91
           k+lkgh+++vitc++f   ++ +++gs+d+t+kvw++ tgk+lr+l gh+++v++ ++ ++  i+++gs+Drt+kvw+ +tg+c+htl 
   Q: 294  KVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLY 378
           6799************..*******************************************..************************** PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
           gh+++v+++++++  +++vsGs+d t+rvwd+etgqcl+ +l gh ++v+cv++++  + +vsG++D +v++Wd +t+++l+tl+g ht
   Q: 379  GHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLH-VLMGHVAAVRCVQYDG--RRVVSGAYDFMVKVWDPETETCLHTLQG-HT 461
           *************..************************.****************..***************************9.** PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvis 269
           ++vysl+fd    ++vsgsld+++++wd++tg+c++tl+gh++ ++ +++   d++lvsg++D +++iWd+++g++l+tlq++n++ ++
   Q: 462  NRVYSLQFDG--IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 546
           *********9..9**************************************..************************************ PP
   S: 270  vavlsfgdnvlvlgsedskvniwklkknep 299
           v++l+f++n +++ s+d++v++w+lk+ e+
   Q: 547  VTCLQFNKNFVITSSDDGTVKLWDLKTGEF 576
           *************************98776 PP

Organism

Bos taurus

Functional Description
(View)

Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation.

Protein Sequence
(Fasta)

MCVPRSGLIL SCICLYCGVL LPVLLPNLPF LTCLSMSTLE SVTYLPEKGL YCQRLPSSRT 60
HGGTESLKGK NPENMGFYGT LKMIFYKMKR KLDHGSEVRS FSLGKKPCKV SEYTSTTGLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATAATTGAT GTGCAGTCTG CATTGCTGAA TCCTGGACTG CACCATTCTG TGTTCAAGGG 60
AAGATGTAAT CTGATCCCTC TGCTGCTGAG GGAGGAATCT CTCCAGTCCA GGCTTTGACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0019005--C:SCF ubiquitin ligase complex
GO:0050816--F:phosphothreonine binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0032876--P:negative regulation of DNA endoreduplication
GO:0045741--P:positive regulation of epidermal growth factor-activated receptor activity
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:1903378--P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1901800--P:positive regulation of proteasomal protein catabolic process
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:1903146--P:regulation of mitophagy
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0007062--P:sister chromatid cohesion

KEGG

bta:540932

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002406	Ailuropoda melanoleuca	99.63	0.00e+00	1098.00
IUUC-Apl-003489	Anas platyrhynchos	98.55	0.00e+00	1100.00
IUUC-Aca-005318	Anolis carolinensis	98.99	0.00e+00	1196.00
IUUC-Ago-007794	Ashbya gossypii	31.07	2.00e-61	229.00
IUUC-Acl-008123	Aspergillus clavatus	32.40	2.00e-74	273.00
IUUC-Afl-008730	Aspergillus flavus	31.33	1.00e-73	271.00
IUUC-Afu-009014	Aspergillus fumigatus	32.53	7.00e-75	275.00
IUUC-Ani-009332	Aspergillus nidulans	33.47	5.00e-80	291.00
IUUC-Ang-009790	Aspergillus niger	31.52	2.00e-75	276.00
IUUC-Aor-010215	Aspergillus oryzae	30.71	4.00e-74	272.00
IUUC-Ate-010535	Aspergillus terreus	32.54	8.00e-76	278.00
IUUC-Ame-010898	Astyanax mexicanus	95.01	0.00e+00	1041.00
IUUC-Bgr-012075	Blumeria graminis	33.47	6.00e-79	288.00
IUUC-Bci-013725	Botrytis cinerea	33.20	6.00e-78	285.00
IUUC-Cel-018495	Caenorhabditis elegans	48.73	6.00e-131	461.00
IUUC-Cja-018902	Callithrix jacchus	100.00	0.00e+00	1100.00
IUUC-Cfa-020237	Canis familiaris	100.00	0.00e+00	1100.00
IUUC-Cpo-022234	Cavia porcellus	99.83	0.00e+00	1203.00
IUUC-Cre-022837	Chlamydomonas reinhardtii	37.42	6.00e-49	188.00
IUUC-Csa-023532	Chlorocebus sabaeus	100.00	0.00e+00	1101.00
IUUC-Cho-025026	Choloepus hoffmanni	82.25	0.00e+00	732.00
IUUC-Cin-025516	Ciona intestinalis	70.34	2.00e-140	491.00
IUUC-Csv-026312	Ciona savignyi	75.47	0.00e+00	749.00
IUUC-Cgl-026492	Colletotrichum gloeosporioides	34.82	2.00e-84	306.00
IUUC-Cne-027018	Cryptococcus neoformans	33.08	2.00e-72	267.00
IUUC-Cme-027168	Cyanidioschyzon merolae	31.11	3.00e-30	127.00
IUUC-Dre-028303	Danio rerio	94.09	0.00e+00	1045.00
IUUC-Dno-029576	Dasypus novemcinctus	97.26	0.00e+00	1081.00
IUUC-Dor-030196	Dipodomys ordii	97.28	0.00e+00	1077.00
IUUC-Dse-031558	Dothistroma septosporum	38.98	6.00e-70	258.00
IUUC-Dme-031702	Drosophila melanogaster	76.61	0.00e+00	799.00
IUUC-Ete-032791	Echinops telfairi	90.93	0.00e+00	999.00
IUUC-Eca-033424	Equus caballus	99.68	0.00e+00	1240.00
IUUC-Eeu-034996	Erinaceus europaeus	95.28	0.00e+00	1061.00
IUUC-Fca-036422	Felis catus	99.27	0.00e+00	1101.00
IUUC-Fal-037267	Ficedula albicollis	98.35	0.00e+00	1091.00
IUUC-Fox-037800	Fusarium oxysporum	34.07	1.00e-83	303.00
IUUC-Fso-038258	Fusarium solani	34.21	1.00e-82	300.00
IUUC-Gmo-039119	Gadus morhua	81.07	0.00e+00	937.00
IUUC-Ggr-039781	Gaeumannomyces graminis	34.66	1.00e-84	307.00
IUUC-Gga-040667	Gallus gallus	99.27	0.00e+00	1102.00
IUUC-Gac-042423	Gasterosteus aculeatus	75.45	0.00e+00	825.00
IUUC-Ggo-044422	Gorilla gorilla	100.00	0.00e+00	1100.00
IUUC-Hsa-045898	Homo sapiens	100.00	0.00e+00	1100.00
IUUC-Itr-048241	Ictidomys tridecemlineatus	99.79	0.00e+00	967.00
IUUC-Kpa-049097	Komagataella pastoris	32.06	9.00e-76	278.00
IUUC-Lch-050414	Latimeria chalumnae	97.97	0.00e+00	1080.00
IUUC-Loc-052348	Lepisosteus oculatus	97.29	0.00e+00	1095.00
IUUC-Lma-053185	Leptosphaeria maculans	32.60	1.00e-72	268.00
IUUC-Laf-054054	Loxodonta africana	99.09	0.00e+00	1101.00
IUUC-Mcc-055056	Macaca mulatta	100.00	0.00e+00	1101.00
IUUC-Meu-056778	Macropus eugenii	96.85	4.00e-180	624.00
IUUC-Mor-057133	Magnaporthe oryzae	39.13	7.00e-73	268.00
IUUC-Mpo-057542	Magnaporthe poae	39.13	2.00e-73	270.00
IUUC-Mla-059081	Melampsora laricipopulina	32.57	3.00e-76	279.00
IUUC-Mga-059255	Meleagris gallopavo	99.09	0.00e+00	1101.00
IUUC-Mvi-060490	Microbotryum violaceum	38.75	1.00e-66	249.00
IUUC-Mmr-061292	Microcebus murinus	100.00	0.00e+00	1099.00
IUUC-Mdo-062304	Monodelphis domestica	98.90	0.00e+00	1105.00
IUUC-Mmu-063610	Mus musculus	98.19	0.00e+00	1100.00
IUUC-Mpu-065931	Mustela putorius furo	100.00	0.00e+00	1099.00
IUUC-Mlu-066976	Myotis lucifugus	98.55	0.00e+00	1102.00
IUUC-Nfi-068428	Neosartorya fischeri	31.93	1.00e-74	274.00
IUUC-Ncr-068688	Neurospora crassa	35.97	8.00e-87	314.00
IUUC-Nle-070174	Nomascus leucogenys	100.00	0.00e+00	1100.00
IUUC-Opr-070851	Ochotona princeps	86.58	0.00e+00	650.00
IUUC-Ont-071997	Oreochromis niloticus	94.58	0.00e+00	1093.00
IUUC-Oan-072936	Ornithorhynchus anatinus	99.09	0.00e+00	1101.00
IUUC-Ocu-074742	Oryctolagus cuniculus	100.00	0.00e+00	1103.00
IUUC-Obr-076806	Oryza brachyantha	31.52	1.00e-29	125.00
IUUC-Oin-079809	Oryza indica	31.52	1.00e-29	125.00
IUUC-Ola-087098	Oryzias latipes	93.39	0.00e+00	1058.00
IUUC-Olu-087837	Ostreococcus lucimarinus	34.47	4.00e-38	151.00
IUUC-Oga-088884	Otolemur garnettii	100.00	0.00e+00	780.00
IUUC-Oar-090220	Ovis aries	99.27	0.00e+00	1097.00
IUUC-Ptr-090492	Pan troglodytes	100.00	0.00e+00	1100.00
IUUC-Pan-091770	Papio anubis	100.00	0.00e+00	1101.00
IUUC-Psi-093207	Pelodiscus sinensis	99.66	0.00e+00	1206.00
IUUC-Pma-094749	Petromyzon marinus	83.84	0.00e+00	965.00
IUUC-Pno-095026	Phaeosphaeria nodorum	38.83	2.00e-70	260.00
IUUC-Pfo-096493	Poecilia formosa	95.56	0.00e+00	1051.00
IUUC-Pab-098141	Pongo abelii	99.84	0.00e+00	1242.00
IUUC-Pca-100571	Procavia capensis	99.74	0.00e+00	779.00
IUUC-Pva-102988	Pteropus vampyrus	98.91	0.00e+00	1101.00
IUUC-Pgr-103612	Puccinia graminis	35.41	2.00e-61	231.00
IUUC-Pte-104275	Pyrenophora teres	32.36	5.00e-73	269.00
IUUC-Pyt-104438	Pyrenophora triticirepentis	31.93	5.00e-72	265.00
IUUC-Rno-105706	Rattus norvegicus	98.00	0.00e+00	1099.00
IUUC-Sce-106314	Saccharomyces cerevisiae	29.39	6.00e-60	225.00
IUUC-Sha-107653	Sarcophilus harrisii	98.90	0.00e+00	1101.00
IUUC-Sja-107840	Schizosaccharomyces japonicus	33.83	1.00e-78	287.00
IUUC-Spo-108115	Schizosaccharomyces pombe	32.14	6.00e-62	231.00
IUUC-Sar-113600	Sorex araneus	92.20	0.00e+00	1008.00
IUUC-Sre-114901	Sporisorium reilianum	48.13	8.00e-67	249.00
IUUC-Ssc-115787	Sus scrofa	96.91	0.00e+00	1074.00
IUUC-Tgu-117510	Taeniopygia guttata	99.08	0.00e+00	1098.00
IUUC-Tru-117819	Takifugu rubripes	95.01	0.00e+00	1076.00
IUUC-Tsy-118828	Tarsius syrichta	98.73	0.00e+00	1100.00
IUUC-Tni-120468	Tetraodon nigroviridis	93.79	0.00e+00	1093.00
IUUC-Tre-122193	Trichoderma reesei	36.25	8.00e-85	308.00
IUUC-Tvi-122615	Trichoderma virens	35.03	3.00e-83	302.00
IUUC-Tme-127021	Tuber melanosporum	34.26	1.00e-83	303.00
IUUC-Tbe-127925	Tupaia belangeri	100.00	0.00e+00	1099.00
IUUC-Ttr-128899	Tursiops truncatus	99.63	0.00e+00	1098.00
IUUC-Uma-129449	Ustilago maydis	46.89	7.00e-66	246.00
IUUC-Vda-129802	Verticillium dahliae	36.05	6.00e-87	315.00
IUUC-Vpa-130082	Vicugna pacos	98.48	0.00e+00	921.00
IUUC-Xtr-132213	Xenopus tropicalis	98.34	0.00e+00	1088.00
IUUC-Xma-133646	Xiphophorus maculatus	95.49	0.00e+00	1074.00
IUUC-Yli-134429	Yarrowia lipolytica	34.27	2.00e-86	313.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence