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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046736
UUCD1 version UUC-HoS-00928
Ensembl Protein ID ENSP00000358862.3
UniProt Accession Q9BYE7; A8K3R4; Q5SYD1; Q5SYD6; Q96ID9; Q96SJ1; PCGF6_HUMAN
Genbank Protein ID BAB40779.1; BAF83368.1; CAI16745.1; CAI16746.1; AAH07602.1; AAH10235.1
Protein Name Polycomb group RING finger protein 6; Mel18 and Bmi1-like RING finger; RING finger protein 134
Genbank Nucleotide ID AB047006; AK027885; AL591408; AL591408; BC007602; BC010235
Gene Name PCGF6; MBLR; RNF134
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000156374.14 ENST00000337211.8 ENSP00000338845.4
ENSG00000156374.14 ENST00000369847.3 ENSP00000358862.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPMSZDB
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
MethyCancerTCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UDP/UFD/RAWUL RAWUL 17320162; 18588675
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.00071 21.7 134 173
ULD/UDP/UFD/RAWUL 1.90e-20 74.8 253 340
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC+  + d + ++ C H+f+++C+ +        + + rCP C+
   Q: 134  CSICKGYLIDATTITECLHTFCKSCIVRH------FYYSNRCPKCN 173
           ********99999*************555......689999**996 PP
   

   ULD/UDP/UFD/RAWUL
   S: 1    islsLeplesnkakddsk.lkkkylrcsarltVkhlkkflaeklklsssyevdllcedevLednetLeeikyifiwk..kegpLvLqY 85
           +sl Le++ +n+ ++++k l+kk++r+s+++t++h++kfl++k+ l+++++vd++c d++Le+++tL+ei++++ +   ++g LvL+Y
   Q: 253  MSLLLEFIGANEGTGHFKpLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLREIRRAIGDAamQDGLLVLHY 340
           799*******************************************************************9999988899******** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
 Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Protein Sequence
(Fasta)
MEGVAVVTAG SVGAAKTEGA AALPPPPPVS PPALTPAPAA GEEGPAPLSE TGAPGCSGSR 60
PPELEPERSL GRFRGRFEDE DEELEEEEEL EEEEEEEEED MSHFSLRLEG GRQDSEDEEE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046736|ULD,RAWUL;E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCGTCCGAG GCCGGCCGAA CTCCCGCGCT CTCCCGCCGC CTCGCCTCGC CTGGTGTCTC 60
TCCCGACCAT GGAGGGGGTC GCGGTGGTGA CGGCGGGCAG CGTAGGCGCT GCCAAAACCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046736|ULD,RAWUL;E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR029071--Ubiquitin-rel_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0003677--F:DNA binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001227--F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG hsa:84108
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001804 Ailuropoda melanoleuca 98.30 6.00e-155 540.00
IUUC-Apl-003651 Anas platyrhynchos 89.52 2.00e-120 424.00
IUUC-Aca-005303 Anolis carolinensis 83.24 9.00e-86 309.00
IUUC-Ath-007327 Arabidopsis thaliana 49.25 8.00e-12 65.10
IUUC-Ame-011707 Astyanax mexicanus 62.93 1.00e-85 309.00
IUUC-Bta-012998 Bos taurus 97.30 7.00e-154 536.00
IUUC-Cja-018814 Callithrix jacchus 99.67 6.00e-151 526.00
IUUC-Cfa-020385 Canis familiaris 98.31 3.00e-156 544.00
IUUC-Cpo-021535 Cavia porcellus 91.53 9.00e-145 506.00
IUUC-Csa-023795 Chlorocebus sabaeus 99.67 6.00e-162 563.00
IUUC-Cho-024728 Choloepus hoffmanni 62.57 4.00e-80 291.00
IUUC-Dre-028499 Danio rerio 60.76 3.00e-82 298.00
IUUC-Dno-029702 Dasypus novemcinctus 98.80 2.00e-142 497.00
IUUC-Ete-032808 Echinops telfairi 92.20 2.00e-132 464.00
IUUC-Eca-033860 Equus caballus 95.95 2.00e-149 521.00
IUUC-Eeu-035280 Erinaceus europaeus 88.86 4.00e-146 510.00
IUUC-Fca-036544 Felis catus 99.60 4.00e-147 513.00
IUUC-Fal-037301 Ficedula albicollis 91.67 3.00e-116 411.00
IUUC-Gmo-038862 Gadus morhua 54.55 2.00e-58 218.00
IUUC-Gga-040130 Gallus gallus 91.30 7.00e-117 413.00
IUUC-Gac-041439 Gasterosteus aculeatus 56.57 8.00e-62 229.00
IUUC-Ggo-045646 Gorilla gorilla 88.31 8.00e-137 479.00
IUUC-Itr-048489 Ictidomys tridecemlineatus 96.61 5.00e-154 536.00
IUUC-Lch-049961 Latimeria chalumnae 79.86 7.00e-59 220.00
IUUC-Loc-052192 Lepisosteus oculatus 66.22 3.00e-84 305.00
IUUC-Laf-053828 Loxodonta africana 98.40 2.00e-142 498.00
IUUC-Mcc-055235 Macaca mulatta 100.00 5.00e-161 560.00
IUUC-Meu-056696 Macropus eugenii 94.51 2.00e-79 288.00
IUUC-Mmr-060686 Microcebus murinus 97.01 9.00e-147 512.00
IUUC-Mdo-062342 Monodelphis domestica 88.85 2.00e-134 472.00
IUUC-Mmu-063449 Mus musculus 94.02 3.00e-152 531.00
IUUC-Mpu-065971 Mustela putorius furo 98.31 2.00e-156 545.00
IUUC-Mlu-068172 Myotis lucifugus 96.27 3.00e-152 531.00
IUUC-Nle-070080 Nomascus leucogenys 81.61 2.00e-135 474.00
IUUC-Oan-073170 Ornithorhynchus anatinus 92.75 1.00e-63 234.00
IUUC-Ocu-074478 Oryctolagus cuniculus 95.29 5.00e-153 533.00
IUUC-Opu-083660 Oryza punctata 46.38 2.00e-11 63.50
IUUC-Ola-086801 Oryzias latipes 63.68 3.00e-85 308.00
IUUC-Oga-088951 Otolemur garnettii 96.18 5.00e-137 480.00
IUUC-Oar-089539 Ovis aries 96.28 1.00e-151 529.00
IUUC-Ptr-090745 Pan troglodytes 100.00 2.00e-162 564.00
IUUC-Pan-091899 Papio anubis 100.00 5.00e-161 560.00
IUUC-Psi-092970 Pelodiscus sinensis 85.78 8.00e-104 369.00
IUUC-Pma-094764 Petromyzon marinus 54.26 8.00e-69 253.00
IUUC-Pfo-096092 Poecilia formosa 60.78 5.00e-82 297.00
IUUC-Pab-098230 Pongo abelii 99.67 3.00e-161 561.00
IUUC-Pca-101116 Procavia capensis 81.71 4.00e-122 431.00
IUUC-Pva-102607 Pteropus vampyrus 86.82 1.00e-116 412.00
IUUC-Rno-106016 Rattus norvegicus 93.69 3.00e-145 508.00
IUUC-Smo-109158 Selaginella moellendorffii 42.31 1.00e-11 64.70
IUUC-Sbi-114041 Sorghum bicolor 44.87 7.00e-13 66.60
IUUC-Tgu-116601 Taeniopygia guttata 91.23 9.00e-116 409.00
IUUC-Tru-117540 Takifugu rubripes 55.47 2.00e-41 160.00
IUUC-Tni-120638 Tetraodon nigroviridis 56.20 2.00e-42 164.00
IUUC-Tbe-127300 Tupaia belangeri 71.98 8.00e-89 319.00
IUUC-Ttr-129281 Tursiops truncatus 92.43 5.00e-148 516.00
IUUC-Vpa-130504 Vicugna pacos 98.70 3.00e-130 457.00
IUUC-Xtr-132184 Xenopus tropicalis 77.43 3.00e-104 370.00
Created Date 25-Jun-2017

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