iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UFD/RAWUL	9.20e-21	74.5	254	341

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/RAWUL

   S: 1    islsLeplesnkakddsk.lkkkylrcsarltVkhlkkflaeklklsssyevdllcedevLednetLeeikyifiwk..kegpLvLqY 85
           +sl Le++ +n++++++k l+kk++r+s+++t++h++kfl++k+ l+++++vd++c d++Le ++tL+ei++++ +   ++g LvL+Y
   Q: 254  VSLLLEFIGANEDTGHFKpLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLERYQTLREIRRAIGDTamQDGLLVLHY 341
           689*******************************************************************9999887889******** PP

Organism

Rattus norvegicus

Functional Description
(View)

Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity).

Protein Sequence
(Fasta)

MEEAETDATE NKRASEAKRA SAMLPPPPPP ISPPALIPAP AAGEEGPASL AQAGAPGCSR 60
SRPPELEPER SLGRLRGRFE DYDEELEEDE EMEEEEEEEE EMSHFSLRLE SGRADSEDEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCACCGGAC TCCCCTCGCC TCGCGCTCAG CTCGCCTGGT TTCTGATCCC CGCCATGGAG 60
GAGGCTGAGA CGGACGCCAC GGAAAACAAG CGCGCCTCTG AGGCCAAGCG AGCCTCGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR029071--Ubiquitin-rel_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227--F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0006351--P:transcription, DNA-templated

KEGG

rno:309457

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001804	Ailuropoda melanoleuca	94.22	5.00e-149	520.00
IUUC-Apl-003651	Anas platyrhynchos	89.52	6.00e-120	422.00
IUUC-Aca-005303	Anolis carolinensis	82.70	3.00e-85	306.00
IUUC-Ame-011707	Astyanax mexicanus	60.83	3.00e-84	304.00
IUUC-Bta-012998	Bos taurus	94.93	9.00e-151	526.00
IUUC-Cja-018814	Callithrix jacchus	93.36	7.00e-143	499.00
IUUC-Cfa-020385	Canis familiaris	94.58	3.00e-150	524.00
IUUC-Cpo-021535	Cavia porcellus	92.18	4.00e-146	510.00
IUUC-Csa-023795	Chlorocebus sabaeus	93.07	4.00e-153	533.00
IUUC-Cho-024728	Choloepus hoffmanni	72.09	8.00e-70	257.00
IUUC-Dre-028499	Danio rerio	60.50	2.00e-81	295.00
IUUC-Dno-029702	Dasypus novemcinctus	94.80	3.00e-138	484.00
IUUC-Ete-032808	Echinops telfairi	90.04	2.00e-131	461.00
IUUC-Eca-033860	Equus caballus	93.24	4.00e-147	513.00
IUUC-Eeu-035280	Erinaceus europaeus	90.17	1.00e-142	499.00
IUUC-Fca-036544	Felis catus	95.60	3.00e-142	497.00
IUUC-Fal-037301	Ficedula albicollis	91.23	2.00e-115	409.00
IUUC-Gmo-038862	Gadus morhua	54.55	4.00e-58	217.00
IUUC-Gga-040130	Gallus gallus	91.30	3.00e-116	411.00
IUUC-Gac-041439	Gasterosteus aculeatus	56.06	4.00e-61	227.00
IUUC-Ggo-045646	Gorilla gorilla	84.04	3.00e-130	457.00
IUUC-Hsa-046736	Homo sapiens	93.38	2.00e-153	535.00
IUUC-Itr-048489	Ictidomys tridecemlineatus	94.58	4.00e-149	520.00
IUUC-Lch-049961	Latimeria chalumnae	81.25	5.00e-60	224.00
IUUC-Loc-052192	Lepisosteus oculatus	66.67	2.00e-84	305.00
IUUC-Laf-053828	Loxodonta africana	95.20	1.00e-139	489.00
IUUC-Mcc-055235	Macaca mulatta	94.00	6.00e-153	533.00
IUUC-Meu-056696	Macropus eugenii	91.46	3.00e-77	281.00
IUUC-Mmr-060686	Microcebus murinus	95.60	6.00e-142	496.00
IUUC-Mdo-062342	Monodelphis domestica	85.76	1.00e-131	462.00
IUUC-Mmu-063449	Mus musculus	96.03	2.00e-164	571.00
IUUC-Mpu-065971	Mustela putorius furo	94.24	1.00e-150	525.00
IUUC-Mlu-068172	Myotis lucifugus	94.58	9.00e-149	519.00
IUUC-Nle-070080	Nomascus leucogenys	77.59	2.00e-129	454.00
IUUC-Oan-073170	Ornithorhynchus anatinus	90.58	3.00e-62	229.00
IUUC-Ocu-074478	Oryctolagus cuniculus	92.93	3.00e-148	518.00
IUUC-Opu-083660	Oryza punctata	46.38	3.00e-11	63.20
IUUC-Ola-086801	Oryzias latipes	64.26	6.00e-85	306.00
IUUC-Oga-088951	Otolemur garnettii	94.89	3.00e-132	464.00
IUUC-Oar-089539	Ovis aries	93.92	7.00e-149	519.00
IUUC-Ptr-090745	Pan troglodytes	93.38	2.00e-153	535.00
IUUC-Pan-091899	Papio anubis	94.00	6.00e-153	533.00
IUUC-Psi-092970	Pelodiscus sinensis	85.33	9.00e-103	365.00
IUUC-Pma-094764	Petromyzon marinus	55.16	1.00e-70	259.00
IUUC-Pfo-096092	Poecilia formosa	59.83	3.00e-81	294.00
IUUC-Pab-098230	Pongo abelii	94.00	5.00e-153	533.00
IUUC-Pca-101116	Procavia capensis	81.60	1.00e-115	409.00
IUUC-Pva-102607	Pteropus vampyrus	84.46	9.00e-116	409.00
IUUC-Smo-109158	Selaginella moellendorffii	42.31	2.00e-11	64.30
IUUC-Sbi-114041	Sorghum bicolor	43.59	2.00e-12	65.50
IUUC-Tgu-116601	Taeniopygia guttata	90.79	4.00e-115	407.00
IUUC-Tni-120638	Tetraodon nigroviridis	57.66	4.00e-42	163.00
IUUC-Tbe-127300	Tupaia belangeri	69.40	4.00e-86	310.00
IUUC-Ttr-129281	Tursiops truncatus	89.14	4.00e-144	504.00
IUUC-Vpa-130504	Vicugna pacos	95.65	1.00e-127	449.00
IUUC-Xtr-132184	Xenopus tropicalis	77.43	2.00e-103	368.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence