iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mcc-054888

UUCD1 version

UUC-MaM-00261

Ensembl Protein ID

ENSMMUP00000015133.2

UniProt Accession

F7C057; F7C057_MACMU

Genbank Protein ID

AFH29654.1; AFI34470.1; AFJ71692.1

Protein Name

TNF receptor-associated factor 2

Genbank Nucleotide ID

JSUE03013795; JV044399; JV636352

Gene Name

TRAF2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000011527.3	ENSMMUT00000016146.3	ENSMMUP00000015133.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	98.40	0.00e+00	1022.00	IUUC-Hsa-046952

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MAAASVTPPG SLELLQPGFS KTLLGTKLEA KYLCSACGNV LRRPFQAQCG HRYCSFCLAS 60
ILSSGPQNCA ACVHEGIYEE GISILESSSA FPDNAARREV ESLPAVCPID GCTWKGTLKE 120

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Nucleotide Sequence
(Fasta)

GGCTTGGTCG TTTGCGGGGG TCACAGCTCT TATGGCTGCA GCTAGCGTGA CCCCCCCTGG 60
CTCCTTGGAG TTGCTACAGC CTGGCTTCTC CAAGACCCTC CTGGGGACCA AGCTGGAAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0675--Receptor
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027133--TRAF2
IPR032070--TRAF_BIRC3-bd
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF16673--TRAF_BIRC3_bd
PF00097--zf-C3HC4
PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:1990597--C:AIP1-IRE1 complex
GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:1990604--C:IRE1-TRAF2-ASK1 complex
GO:0045121--C:membrane raft
GO:0097057--C:TRAF2-GSTP1 complex
GO:0000151--C:ubiquitin ligase complex
GO:0012506--C:vesicle membrane
GO:0046625--F:sphingolipid binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0043623--P:cellular protein complex assembly
GO:0071732--P:cellular response to nitric oxide
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:1903721--P:positive regulation of I-kappaB phosphorylation
GO:0032743--P:positive regulation of interleukin-2 production
GO:0043507--P:positive regulation of JUN kinase activity
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0090073--P:positive regulation of protein homodimerization activity
GO:0002726--P:positive regulation of T cell cytokine production
GO:1903265--P:positive regulation of tumor necrosis factor-mediated signaling pathway
GO:0097300--P:programmed necrotic cell death
GO:0051865--P:protein autoubiquitination
GO:0030163--P:protein catabolic process
GO:0070207--P:protein homotrimerization
GO:0070534--P:protein K63-linked ubiquitination
GO:0051023--P:regulation of immunoglobulin secretion
GO:0033209--P:tumor necrosis factor-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002344	Ailuropoda melanoleuca	86.04	0.00e+00	903.00
IUUC-Apl-004202	Anas platyrhynchos	74.48	0.00e+00	827.00
IUUC-Aca-005029	Anolis carolinensis	59.16	4.00e-149	521.00
IUUC-Ame-011841	Astyanax mexicanus	55.65	0.00e+00	638.00
IUUC-Bta-013180	Bos taurus	86.13	0.00e+00	889.00
IUUC-Cja-019813	Callithrix jacchus	96.81	0.00e+00	1010.00
IUUC-Cfa-021205	Canis familiaris	90.62	0.00e+00	917.00
IUUC-Cpo-021346	Cavia porcellus	89.42	0.00e+00	924.00
IUUC-Csa-023809	Chlorocebus sabaeus	98.43	0.00e+00	914.00
IUUC-Dre-027669	Danio rerio	58.93	1.00e-177	616.00
IUUC-Dno-029458	Dasypus novemcinctus	84.14	0.00e+00	890.00
IUUC-Dor-030338	Dipodomys ordii	86.43	0.00e+00	829.00
IUUC-Eca-034401	Equus caballus	90.30	0.00e+00	944.00
IUUC-Eeu-034668	Erinaceus europaeus	70.68	1.00e-107	383.00
IUUC-Fca-036057	Felis catus	86.62	0.00e+00	926.00
IUUC-Fal-037560	Ficedula albicollis	72.83	0.00e+00	734.00
IUUC-Gmo-038964	Gadus morhua	63.02	0.00e+00	664.00
IUUC-Gga-040425	Gallus gallus	75.14	0.00e+00	825.00
IUUC-Gac-041908	Gasterosteus aculeatus	64.29	0.00e+00	681.00
IUUC-Ggo-044606	Gorilla gorilla	90.42	0.00e+00	929.00
IUUC-Hsa-046952	Homo sapiens	98.40	0.00e+00	1022.00
IUUC-Itr-049016	Ictidomys tridecemlineatus	76.45	0.00e+00	777.00
IUUC-Lch-049571	Latimeria chalumnae	59.41	0.00e+00	705.00
IUUC-Loc-051973	Lepisosteus oculatus	62.98	0.00e+00	631.00
IUUC-Laf-053815	Loxodonta africana	84.09	0.00e+00	852.00
IUUC-Meu-056547	Macropus eugenii	74.43	0.00e+00	666.00
IUUC-Mga-059819	Meleagris gallopavo	75.05	0.00e+00	781.00
IUUC-Mdo-062570	Monodelphis domestica	81.27	0.00e+00	853.00
IUUC-Mmu-063133	Mus musculus	87.03	0.00e+00	871.00
IUUC-Mpu-065802	Mustela putorius furo	87.70	0.00e+00	923.00
IUUC-Nle-070155	Nomascus leucogenys	98.40	0.00e+00	1023.00
IUUC-Opr-070856	Ochotona princeps	86.84	3.00e-115	408.00
IUUC-Ont-071930	Oreochromis niloticus	64.30	0.00e+00	708.00
IUUC-Ola-087397	Oryzias latipes	61.08	0.00e+00	686.00
IUUC-Oga-088109	Otolemur garnettii	94.21	0.00e+00	988.00
IUUC-Oar-090310	Ovis aries	76.49	0.00e+00	791.00
IUUC-Ptr-090643	Pan troglodytes	98.60	0.00e+00	1023.00
IUUC-Pan-091933	Papio anubis	99.40	0.00e+00	1036.00
IUUC-Psi-093681	Pelodiscus sinensis	73.53	0.00e+00	781.00
IUUC-Pfo-096148	Poecilia formosa	60.71	0.00e+00	692.00
IUUC-Pab-098631	Pongo abelii	98.40	0.00e+00	1024.00
IUUC-Pca-100582	Procavia capensis	67.05	2.00e-89	323.00
IUUC-Pva-102396	Pteropus vampyrus	75.05	0.00e+00	741.00
IUUC-Rno-106120	Rattus norvegicus	86.63	0.00e+00	857.00
IUUC-Sha-106493	Sarcophilus harrisii	82.87	0.00e+00	874.00
IUUC-Sar-113570	Sorex araneus	93.92	2.00e-100	358.00
IUUC-Ssc-115843	Sus scrofa	85.00	0.00e+00	914.00
IUUC-Tgu-117144	Taeniopygia guttata	69.79	0.00e+00	704.00
IUUC-Tru-117853	Takifugu rubripes	62.33	0.00e+00	689.00
IUUC-Tni-120256	Tetraodon nigroviridis	65.27	0.00e+00	717.00
IUUC-Tbe-127943	Tupaia belangeri	66.33	9.00e-102	363.00
IUUC-Ttr-129246	Tursiops truncatus	89.09	0.00e+00	902.00
IUUC-Xtr-132279	Xenopus tropicalis	60.48	4.00e-173	600.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence