iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000151876.12	ENST00000513496.5	ENSP00000424750.1
ENSG00000151876.12	ENST00000296812.6	ENSP00000296812.2
ENSG00000151876.12	ENST00000281623.7	ENSP00000281623.3
ENSG00000151876.12	ENST00000504463.5	ENSP00000424991.1
ENSG00000151876.12	ENST00000509134.1	ENSP00000421749.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	20181953; 19683498; 19343786; 19221502; 15520277

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.02	16.6	46	101

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 91   tptpee.gpdaglldrlpeeilveilklldkeellraarvcrrwqelasqkalwkt 145
           t + ee +  a++l+rlp ++++ il++l++++l+++ ++ + w+e+ +++ lw+ 
   Q: 46   TTSREEvDEAASTLTRLPIDVQLYILSFLSPHDLCQLGSTNHYWNETVRDPILWRY 101
           444444145678899******************************99999999985 PP

Organism

Homo sapiens

Functional Description
(View)

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.

Protein Sequence
(Fasta)

MAGSEPRSGT NSPPPPFSDW GRLEAAILSG WKTFWQSVSK ERVARTTSRE EVDEAASTLT 60
RLPIDVQLYI LSFLSPHDLC QLGSTNHYWN ETVRDPILWR YFLLRDLPSW SSVDWKSLPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGGCTGAC GCGCTAGCGT GGCTCTAAGA CGCGTCACCC ACGCTGCGGG CAAGCCATGG 60
CGGGAAGCGA GCCGCGCAGC GGAACAAACT CGCCGCCGCC GCCCTTCAGC GACTGGGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom

PROSITE

PS50181--FBOX

Pfam

PF00646--F-box

SMART

SM00256--FBOX

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0019005--C:SCF ubiquitin ligase complex
GO:0000151--C:ubiquitin ligase complex
GO:0042803--F:protein homodimerization activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007568--P:aging
GO:0019725--P:cellular homeostasis
GO:0071479--P:cellular response to ionizing radiation
GO:0035726--P:common myeloid progenitor cell proliferation
GO:0048147--P:negative regulation of fibroblast proliferation
GO:1900181--P:negative regulation of protein localization to nucleus
GO:1902916--P:positive regulation of protein polyubiquitination
GO:0031398--P:positive regulation of protein ubiquitination
GO:0010608--P:posttranscriptional regulation of gene expression
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:2000001--P:regulation of DNA damage checkpoint
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0000723--P:telomere maintenance
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:26272

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001232	Ailuropoda melanoleuca	91.33	0.00e+00	685.00
IUUC-Apl-004129	Anas platyrhynchos	63.45	1.00e-111	395.00
IUUC-Aca-005076	Anolis carolinensis	50.00	3.00e-110	392.00
IUUC-Aly-006351	Arabidopsis lyrata	37.21	1.00e-03	37.40
IUUC-Ath-007114	Arabidopsis thaliana	33.85	3.00e-04	39.30
IUUC-Ame-011122	Astyanax mexicanus	47.04	2.00e-86	312.00
IUUC-Bta-012449	Bos taurus	90.44	0.00e+00	686.00
IUUC-Bol-015278	Brassica oleracea	23.17	1.00e-04	40.80
IUUC-Cja-019890	Callithrix jacchus	95.87	0.00e+00	757.00
IUUC-Cfa-021134	Canis familiaris	89.92	0.00e+00	689.00
IUUC-Cpo-021693	Cavia porcellus	90.43	4.00e-171	593.00
IUUC-Csa-023540	Chlorocebus sabaeus	98.71	0.00e+00	754.00
IUUC-Dre-028667	Danio rerio	47.27	5.00e-87	314.00
IUUC-Dno-028997	Dasypus novemcinctus	90.71	0.00e+00	674.00
IUUC-Dor-030135	Dipodomys ordii	80.00	3.00e-154	538.00
IUUC-Ete-033149	Echinops telfairi	85.09	0.00e+00	647.00
IUUC-Eca-033292	Equus caballus	92.90	1.00e-176	612.00
IUUC-Eeu-034504	Erinaceus europaeus	73.15	2.00e-128	451.00
IUUC-Fca-036476	Felis catus	91.73	0.00e+00	745.00
IUUC-Fal-036711	Ficedula albicollis	63.66	1.00e-120	425.00
IUUC-Gmo-039592	Gadus morhua	48.60	8.00e-86	310.00
IUUC-Gga-040924	Gallus gallus	64.00	5.00e-126	444.00
IUUC-Gac-041791	Gasterosteus aculeatus	50.15	1.00e-84	306.00
IUUC-Ggo-044736	Gorilla gorilla	99.22	0.00e+00	758.00
IUUC-Itr-048956	Ictidomys tridecemlineatus	90.96	0.00e+00	682.00
IUUC-Lch-049817	Latimeria chalumnae	66.46	1.00e-128	452.00
IUUC-Loc-052226	Lepisosteus oculatus	51.77	7.00e-108	384.00
IUUC-Laf-054371	Loxodonta africana	90.18	0.00e+00	693.00
IUUC-Mcc-054904	Macaca mulatta	98.45	0.00e+00	753.00
IUUC-Meu-056192	Macropus eugenii	56.79	9.00e-92	330.00
IUUC-Mmr-061692	Microcebus murinus	91.21	0.00e+00	717.00
IUUC-Mdo-062666	Monodelphis domestica	75.68	2.00e-158	551.00
IUUC-Mmu-064223	Mus musculus	88.11	0.00e+00	715.00
IUUC-Mpu-066290	Mustela putorius furo	91.99	0.00e+00	694.00
IUUC-Mlu-067882	Myotis lucifugus	89.41	0.00e+00	699.00
IUUC-Nle-070162	Nomascus leucogenys	98.45	0.00e+00	751.00
IUUC-Opr-070789	Ochotona princeps	85.62	2.00e-74	272.00
IUUC-Ont-071690	Oreochromis niloticus	44.70	1.00e-77	283.00
IUUC-Oan-072928	Ornithorhynchus anatinus	73.46	3.00e-114	404.00
IUUC-Ocu-073857	Oryctolagus cuniculus	90.51	0.00e+00	640.00
IUUC-Ogu-078061	Oryza glumaepatula	31.15	6.20e-01	31.20
IUUC-Oni-083091	Oryza nivara	31.15	6.10e-01	31.20
IUUC-Oru-085096	Oryza rufipogon	31.15	6.00e-01	30.80
IUUC-Osa-086253	Oryza sativa	33.33	2.40e-01	30.40
IUUC-Ola-086607	Oryzias latipes	46.99	7.00e-84	304.00
IUUC-Oga-088929	Otolemur garnettii	93.17	0.00e+00	669.00
IUUC-Oar-089305	Ovis aries	94.14	4.00e-179	620.00
IUUC-Ptr-090813	Pan troglodytes	94.32	0.00e+00	724.00
IUUC-Pan-092924	Papio anubis	96.68	0.00e+00	678.00
IUUC-Psi-093237	Pelodiscus sinensis	67.47	2.00e-132	465.00
IUUC-Pfo-096259	Poecilia formosa	47.25	5.00e-86	311.00
IUUC-Pab-098292	Pongo abelii	98.97	0.00e+00	755.00
IUUC-Pva-102221	Pteropus vampyrus	92.51	0.00e+00	724.00
IUUC-Rno-105910	Rattus norvegicus	88.63	0.00e+00	715.00
IUUC-Sha-106998	Sarcophilus harrisii	76.82	6.00e-162	563.00
IUUC-Sar-113033	Sorex araneus	78.55	2.00e-172	598.00
IUUC-Ssc-115507	Sus scrofa	89.66	0.00e+00	654.00
IUUC-Tgu-116502	Taeniopygia guttata	63.25	4.00e-117	414.00
IUUC-Tru-118203	Takifugu rubripes	44.57	4.00e-75	275.00
IUUC-Tni-120249	Tetraodon nigroviridis	48.18	5.00e-76	278.00
IUUC-Tur-126361	Triticum urartu	26.15	1.00e-03	37.00
IUUC-Tbe-128100	Tupaia belangeri	68.16	2.00e-121	428.00
IUUC-Ttr-128299	Tursiops truncatus	82.17	0.00e+00	629.00
IUUC-Vpa-130394	Vicugna pacos	79.59	7.00e-167	580.00
IUUC-Xtr-131825	Xenopus tropicalis	55.32	4.00e-122	431.00
IUUC-Xma-133942	Xiphophorus maculatus	47.17	8.00e-89	320.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence