iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-034358

UUCD1 version

UUC-EqC-00220

Ensembl Protein ID

ENSECAP00000013178.1

UniProt Accession

F6TDS2; F6TDS2_HORSE

Protein Name

Uncharacterized protein

Gene Name

HERC5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000015395.1	ENSECAT00000016316.1	ENSECAP00000013178.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.40e-90	301.5	642	963

Active Site

Position(s)	Description	Evidence
933	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl+++l v+f+gE  ld+gGv  ef+++l++el +p++glf+y e+ +++++p + ++    e+ ++F f+G+l+g++l++ ++ ++
   Q: 642  NEDLRRELLVSFSGEIPLDYGGVRAEFFHCLFEELTQPEYGLFTYPEEASYMWFPVRPKF----EKKSYF-FFGVLCGLCLFNCNVANI 725
           68999******************************************************9....567888.99**************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           p++ +++k+ll++  sledl+e+ p + +sl+ +++ + +d  e  + + f+    +  ++++eeL+p+G++i V ++Nk++Yv++ v+
   Q: 726  PFPLALFKKLLDQTPSLEDLKELSPVFGRSLQTLLDDEGEDFGEV-FYIHFT----VHWDRNAEELIPNGSDIIVDQTNKRDYVSKCVN 809
           ***********************************8865555554.555555....6678999************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           y+++ +ik  +e+f++Gf++v+++e++  F++ el+ +i G++++d+e+++k+++y ggy +++p+i +Fwe+l++++ ee+k+fL F+
   Q: 810  YIFNISIKAVYEEFQRGFYKVCDKEIIGFFHPAELKDVIIGNTDYDWETFEKNARYAGGYDSSHPTIVMFWEALHKLTLEEKKKFLVFL 898
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg++rl ++G++++k   f++++  ++++ ++++TCf++L LP+Ys++e ++e L++Ai++++gF+
   Q: 899  TGTDRLQVKGVKNMK-ITFCCPEHLDEKDPIRAQTCFSVLYLPKYSTMERVEEALQVAINNNRGFG 963
           ***************.77999998999*************************************96 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

CTRGRLAVLE RAGAGFPCFL PAGSDGTRKP KCIKLGRKMK IHSMDQGAEH LLVLSSDGKP 60
FEYNYSIEHA RFQCVLQEKN IIQITCGDYH SLALSKGGEL FAWGQNTYGQ LGVGRTFAST 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCACGCGCG GGCGCCTGGC GGTGCTGGAG CGCGCCGGGG CCGGCTTCCC GTGCTTTAGC 60
TGCCGGCGGG CAGCGACGGC ACCAGGAAGC CCAGTGAGTG GGCTCGGGCA GCTTCAACTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0042296--F:ISG15 transferase activity
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0032020--P:ISG15-protein conjugation
GO:0050688--P:regulation of defense response to virus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001676	Ailuropoda melanoleuca	82.54	0.00e+00	1677.00
IUUC-Bta-012422	Bos taurus	74.79	0.00e+00	1366.00
IUUC-Cja-018751	Callithrix jacchus	74.69	0.00e+00	1471.00
IUUC-Cfa-020247	Canis familiaris	83.98	0.00e+00	1626.00
IUUC-Csa-023204	Chlorocebus sabaeus	76.70	0.00e+00	1378.00
IUUC-Cho-025101	Choloepus hoffmanni	64.04	0.00e+00	645.00
IUUC-Dno-029795	Dasypus novemcinctus	73.47	0.00e+00	1149.00
IUUC-Dor-030862	Dipodomys ordii	68.32	0.00e+00	1280.00
IUUC-Ete-032585	Echinops telfairi	61.12	0.00e+00	860.00
IUUC-Eeu-035282	Erinaceus europaeus	69.69	0.00e+00	783.00
IUUC-Fca-036505	Felis catus	82.56	0.00e+00	1666.00
IUUC-Ggo-045445	Gorilla gorilla	73.63	0.00e+00	1385.00
IUUC-Hsa-046342	Homo sapiens	76.01	0.00e+00	1459.00
IUUC-Itr-049004	Ictidomys tridecemlineatus	71.55	0.00e+00	1417.00
IUUC-Laf-053921	Loxodonta africana	74.46	0.00e+00	1461.00
IUUC-Mcc-054850	Macaca mulatta	76.59	0.00e+00	1381.00
IUUC-Mmr-060783	Microcebus murinus	66.56	0.00e+00	1208.00
IUUC-Mpu-066123	Mustela putorius furo	81.37	0.00e+00	1632.00
IUUC-Mlu-067914	Myotis lucifugus	79.68	0.00e+00	1489.00
IUUC-Nle-069986	Nomascus leucogenys	75.59	0.00e+00	1479.00
IUUC-Opr-070513	Ochotona princeps	70.63	0.00e+00	1016.00
IUUC-Ocu-074305	Oryctolagus cuniculus	72.92	0.00e+00	1393.00
IUUC-Oar-089456	Ovis aries	82.63	0.00e+00	1570.00
IUUC-Ptr-091216	Pan troglodytes	75.86	0.00e+00	1311.00
IUUC-Pan-091706	Papio anubis	75.31	0.00e+00	1400.00
IUUC-Pca-100320	Procavia capensis	67.46	0.00e+00	1324.00
IUUC-Pva-102646	Pteropus vampyrus	83.44	0.00e+00	1645.00
IUUC-Sar-113605	Sorex araneus	78.68	4.00e-157	548.00
IUUC-Tsy-119240	Tarsius syrichta	65.06	0.00e+00	1219.00
IUUC-Tbe-127787	Tupaia belangeri	71.81	0.00e+00	1367.00
IUUC-Ttr-128191	Tursiops truncatus	80.35	0.00e+00	1556.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence