iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-036505

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02071018

Gene Name

HERC5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000006163.3	ENSFCAT00000006165.3	ENSFCAP00000005729.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.70e-88	297.3	680	1001

Active Site

Position(s)	Description	Evidence
971	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++dl+++l+v+f+gE g+d gGv+ ef+++l++e+ +p++g+f+y e+ +++++p + ++    e+ ++F f+G+l+g++l++ ++ 
   Q: 680  NEDLRRELMVSFSGEIGHDSGGVKVEFFHCLFEEMTRPEYGMFTYPEEASYMWFPVRPKF----EKKRYF-FFGVLCGLSLFNFNVA 761
           6899*******************************************************9....567888.99************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           ++p++ +++k+ll++  sledl+e+ p l ksl+ +++ + +d  e  + + f     +  + ++++L+p+G+ i V ++Nk++Yv+
   Q: 762  NIPFPLALFKKLLNQAPSLEDLKELSPVLGKSLQTLLDDEGDDFGEV-FYIYFN----VHWDKNDVDLIPNGRCIIVDQTNKRDYVS 843
           *************************************8855555554.666665....666789999******************** PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           + v+y+++ ++k  +e+f++Gf++v+++++++ F++eel+ +i G++++d+e+++k++ y++gy +++p+i +Fw++l++++ ee+k
   Q: 844  KCVNYIFNISVKAVYEEFQRGFYKVCEKDIIEFFHPEELKDVIVGNTDYDWETFEKNAHYEEGYDNSHPTIVMFWKALHKLTLEEKK 930
           *************************************************************************************** PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +fL F+Tg++r+ ++G++++k   f+++++ ++++ ++++TC+++L LP+Ys++e ++e L++Ai++++gF+
   Q: 931  KFLVFLTGTDRIQVKGLKNMK-ITFCCPENMNEKDPIRAQTCISVLYLPKYSTMERVEEALQVAINNSRGFG 1001
           *********************.77999999****************************************96 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MERRPRRGAR GSARSAPGPA PALRTTEATR QMCCTRGRLV VLERGGAGVE VHQLAGSDGT 60
RKPKCIKLGK KAKIHSVDQG AEYMLILSSD GKPFEYNYSI EHASRFQCIL QEKIIQITCG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCGGA GGCCACGAAG GGGGGCGCGG GGCAGCGCGC GCTCGGCTCC CGGGCCGGCC 60
CCGGCGCTTC GAACCACAGC GCNNNNNNNN NNNNNNNNNN NNCGAGGCGA CGCGCCAGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0042296--F:ISG15 transferase activity
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0032020--P:ISG15-protein conjugation
GO:0050688--P:regulation of defense response to virus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001676	Ailuropoda melanoleuca	90.72	0.00e+00	1867.00
IUUC-Bta-012422	Bos taurus	74.34	0.00e+00	1372.00
IUUC-Cja-018751	Callithrix jacchus	77.90	0.00e+00	1548.00
IUUC-Cfa-020247	Canis familiaris	92.37	0.00e+00	1789.00
IUUC-Csa-023204	Chlorocebus sabaeus	77.63	0.00e+00	1402.00
IUUC-Cho-025101	Choloepus hoffmanni	66.47	0.00e+00	679.00
IUUC-Dno-029795	Dasypus novemcinctus	73.83	0.00e+00	1187.00
IUUC-Dor-030862	Dipodomys ordii	68.67	0.00e+00	1305.00
IUUC-Ete-032585	Echinops telfairi	61.04	0.00e+00	856.00
IUUC-Eca-034358	Equus caballus	82.56	0.00e+00	1632.00
IUUC-Eeu-035282	Erinaceus europaeus	73.16	0.00e+00	828.00
IUUC-Ggo-045445	Gorilla gorilla	75.05	0.00e+00	1425.00
IUUC-Hsa-046342	Homo sapiens	77.60	0.00e+00	1499.00
IUUC-Itr-049004	Ictidomys tridecemlineatus	74.17	0.00e+00	1480.00
IUUC-Laf-053921	Loxodonta africana	74.73	0.00e+00	1509.00
IUUC-Mcc-054850	Macaca mulatta	77.53	0.00e+00	1404.00
IUUC-Mmr-060783	Microcebus murinus	67.55	0.00e+00	1232.00
IUUC-Mpu-066123	Mustela putorius furo	89.31	0.00e+00	1821.00
IUUC-Mlu-067914	Myotis lucifugus	81.68	0.00e+00	1522.00
IUUC-Nle-069986	Nomascus leucogenys	77.09	0.00e+00	1518.00
IUUC-Opr-070513	Ochotona princeps	72.11	0.00e+00	1048.00
IUUC-Ocu-074305	Oryctolagus cuniculus	74.50	0.00e+00	1443.00
IUUC-Oar-089456	Ovis aries	84.56	0.00e+00	1637.00
IUUC-Ptr-091216	Pan troglodytes	77.61	0.00e+00	1360.00
IUUC-Pan-091706	Papio anubis	77.04	0.00e+00	1475.00
IUUC-Pca-100320	Procavia capensis	68.82	0.00e+00	1358.00
IUUC-Pva-102646	Pteropus vampyrus	87.97	0.00e+00	1749.00
IUUC-Sar-113605	Sorex araneus	79.17	1.00e-157	550.00
IUUC-Ssc-116076	Sus scrofa	82.37	0.00e+00	637.00
IUUC-Tsy-119240	Tarsius syrichta	66.49	0.00e+00	1251.00
IUUC-Tbe-127787	Tupaia belangeri	73.53	0.00e+00	1397.00
IUUC-Ttr-128191	Tursiops truncatus	80.76	0.00e+00	1606.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence