iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-021269

Ensembl Protein ID

ENSCAFP00000027983.3

UniProt Accession

E2R0Z1; E2R0Z1_CANLF

Genbank Protein ID

ENSCAFP00000027983

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03026954

Gene Name

ARHGEF6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000018952.4	ENSCAFT00000030108.3	ENSCAFP00000027983.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.20e-14	52.9	163	217

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            v++ ++++ +n+deL+  kGd+++v     +++gW++g  +l+g+ G fP+n+v++++
   Q: 163  IVKARFNFKQTNEDELSVCKGDIIYVT--RVEEGGWWEG--TLNGRTGWFPSNYVREIK 217
           68999*********************7..999*******..8**************997 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MNPEERIVTW LISLGVLDSP KKTICDPEEF LKSSLKNGVV LCKLINRLRP GSLEKYCLEP 60
QTEADCLNNI SDFLKGCAAL QVEVFDPDDL YSGANFSKVL STLLAVNKAT EDQLSERPCG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATCCAG AAGAGCGAAT CGTGACATGG CTTATATCCT TGGGAGTTTT AGATTCCCCC 60
AAAAAGACCA TCTGTGATCC AGAGGAGTTC TTGAAGTCCT CGCTGAAAAA TGGGGTAGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR032409--GEF_CC
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF16523--betaPIX_CC
PF00307--CH
PF00169--PH
PF00621--RhoGEF
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005622--C:intracellular
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0035556--P:intracellular signal transduction
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001631	Ailuropoda melanoleuca	81.55	0.00e+00	1299.00
IUUC-Apl-003960	Anas platyrhynchos	74.74	0.00e+00	1127.00
IUUC-Aca-004988	Anolis carolinensis	70.31	0.00e+00	1043.00
IUUC-Ame-011546	Astyanax mexicanus	62.82	0.00e+00	947.00
IUUC-Bta-013527	Bos taurus	94.59	0.00e+00	1426.00
IUUC-Cja-018935	Callithrix jacchus	93.56	0.00e+00	1394.00
IUUC-Cpo-021620	Cavia porcellus	87.58	0.00e+00	1302.00
IUUC-Csa-023415	Chlorocebus sabaeus	94.07	0.00e+00	1401.00
IUUC-Dre-028580	Danio rerio	62.83	0.00e+00	962.00
IUUC-Dno-029201	Dasypus novemcinctus	88.86	0.00e+00	1365.00
IUUC-Dor-030868	Dipodomys ordii	75.13	0.00e+00	1017.00
IUUC-Eca-033500	Equus caballus	94.59	0.00e+00	1400.00
IUUC-Eeu-035269	Erinaceus europaeus	82.18	5.00e-169	588.00
IUUC-Fca-035683	Felis catus	96.13	0.00e+00	1409.00
IUUC-Fal-037611	Ficedula albicollis	75.06	0.00e+00	1126.00
IUUC-Gmo-038980	Gadus morhua	60.76	0.00e+00	910.00
IUUC-Gga-040940	Gallus gallus	73.84	0.00e+00	1120.00
IUUC-Gac-042203	Gasterosteus aculeatus	59.44	0.00e+00	932.00
IUUC-Ggo-044755	Gorilla gorilla	94.33	0.00e+00	1403.00
IUUC-Hsa-046210	Homo sapiens	93.81	0.00e+00	1399.00
IUUC-Lch-049517	Latimeria chalumnae	68.99	0.00e+00	1044.00
IUUC-Loc-052393	Lepisosteus oculatus	63.94	0.00e+00	1019.00
IUUC-Laf-054196	Loxodonta africana	90.71	0.00e+00	1326.00
IUUC-Mcc-055716	Macaca mulatta	93.94	0.00e+00	1399.00
IUUC-Meu-056285	Macropus eugenii	72.51	0.00e+00	674.00
IUUC-Mtr-058576	Medicago truncatula	44.62	4.00e-11	62.40
IUUC-Mga-060029	Meleagris gallopavo	75.00	0.00e+00	1142.00
IUUC-Mmr-060803	Microcebus murinus	93.04	0.00e+00	1382.00
IUUC-Mdo-062654	Monodelphis domestica	79.56	0.00e+00	1223.00
IUUC-Mmu-063479	Mus musculus	90.06	0.00e+00	1318.00
IUUC-Mpu-066065	Mustela putorius furo	95.62	0.00e+00	1398.00
IUUC-Mlu-068222	Myotis lucifugus	92.02	0.00e+00	1354.00
IUUC-Nle-069379	Nomascus leucogenys	94.33	0.00e+00	1404.00
IUUC-Opr-070687	Ochotona princeps	73.82	0.00e+00	825.00
IUUC-Ont-072240	Oreochromis niloticus	58.64	0.00e+00	906.00
IUUC-Oan-073067	Ornithorhynchus anatinus	80.77	0.00e+00	1229.00
IUUC-Ocu-074852	Oryctolagus cuniculus	93.30	0.00e+00	1374.00
IUUC-Oga-089048	Otolemur garnettii	86.36	0.00e+00	1195.00
IUUC-Oar-089339	Ovis aries	94.33	0.00e+00	1419.00
IUUC-Pan-092666	Papio anubis	91.65	0.00e+00	1348.00
IUUC-Psi-093116	Pelodiscus sinensis	74.90	0.00e+00	1164.00
IUUC-Pma-094701	Petromyzon marinus	53.24	2.00e-111	395.00
IUUC-Pfo-097394	Poecilia formosa	60.81	0.00e+00	920.00
IUUC-Pab-098567	Pongo abelii	94.59	0.00e+00	1406.00
IUUC-Pca-100997	Procavia capensis	79.90	0.00e+00	1120.00
IUUC-Pva-102500	Pteropus vampyrus	91.88	0.00e+00	1336.00
IUUC-Rno-104974	Rattus norvegicus	90.19	0.00e+00	1296.00
IUUC-Sar-113420	Sorex araneus	87.63	0.00e+00	1285.00
IUUC-Ssc-115679	Sus scrofa	94.94	0.00e+00	1244.00
IUUC-Tgu-117069	Taeniopygia guttata	74.55	0.00e+00	1117.00
IUUC-Tru-118488	Takifugu rubripes	56.27	0.00e+00	824.00
IUUC-Tsy-119243	Tarsius syrichta	85.42	0.00e+00	948.00
IUUC-Tni-120584	Tetraodon nigroviridis	59.77	0.00e+00	915.00
IUUC-Tbe-127994	Tupaia belangeri	77.32	0.00e+00	1125.00
IUUC-Ttr-128839	Tursiops truncatus	92.91	0.00e+00	1353.00
IUUC-Vpa-130144	Vicugna pacos	85.34	0.00e+00	1205.00
IUUC-Xtr-132624	Xenopus tropicalis	69.91	0.00e+00	1071.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence