iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-063454

UUCD1 version

UUC-MuM-00484

Ensembl Protein ID

ENSMUSP00000037971.8

UniProt Accession

Q62511; Q3TEQ3; Q3UH61; Q62509; Q6P219; Q6PG06; Q8BPY3; Q8C2B4; Q8CDZ3; ZFP91_MOUSE

Genbank Protein ID

AAA81911.1; AAA81913.1; BAC26394.1; BAC34808.1; BAC40660.1; BAE27956.1; BAE27996.1; BAE41195.1; AAH57323.1; AAH64766.1; AAH83000.1

Protein Name

E3 ubiquitin-protein ligase ZFP91; Penta Zf protein; RING-type E3 ubiquitin transferase ZFP91; Zinc finger protein 91 homolog; Zinc finger protein PZF

Genbank Nucleotide ID

U05342; U05343; AK029319; AK051904; AK088933; AK147502; AK147560; AK169477; BC057323; BC064766; BC083000

Gene Name

Zfp91; Pzf

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000024695.15	ENSMUST00000142247.7	ENSMUSP00000124424.1
ENSMUSG00000024695.15	ENSMUST00000038627.8	ENSMUSP00000037971.8

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	TRANSFAC	RepTar	miRNAMap
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	88.85	5.00e-164	575.00	IUUC-Hsa-046953

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.

Protein Sequence
(Fasta)

MPGETEEPRS PEQQDQEGGP AAAADAASEE LRPGAAAAPA APAETASSRV LRGGRDRGRT 60
AAAAAAAAAA VSRRRKAEYP RRRRSSPSNR PPDGPGHQPA AAKPPSPAQG KKSPRLQCIE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCATTTTTT CAGAGACTTT CATCCGGCAA CGGACAGGGC CTTTTTTTTC TTAAAGGAGA 60
AGCTGCAACT CAAATAATTT ACCACTTCTC CCCTCGAGAG CTGGCGGCGC TGGGGACAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004039--Rubredoxin-type_fold
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

SMART

SM00355--ZnF_C2H2

Gene Ontology

GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0003676--F:nucleic acid binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0070534--P:protein K63-linked ubiquitination

KEGG

mmu:109910

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001568	Ailuropoda melanoleuca	95.88	1.00e-174	606.00
IUUC-Apl-003922	Anas platyrhynchos	89.35	9.00e-121	426.00
IUUC-Aca-004295	Anolis carolinensis	88.21	4.00e-131	461.00
IUUC-Ame-011459	Astyanax mexicanus	85.09	8.00e-81	295.00
IUUC-Bta-013396	Bos taurus	88.58	6.00e-150	524.00
IUUC-Cja-018863	Callithrix jacchus	92.12	8.00e-171	593.00
IUUC-Cpo-021683	Cavia porcellus	90.62	1.00e-175	609.00
IUUC-Csa-024073	Chlorocebus sabaeus	92.32	2.00e-169	588.00
IUUC-Cho-024818	Choloepus hoffmanni	84.68	3.00e-158	551.00
IUUC-Dre-028207	Danio rerio	91.48	3.00e-90	326.00
IUUC-Dno-029304	Dasypus novemcinctus	93.97	2.00e-168	585.00
IUUC-Dor-030107	Dipodomys ordii	83.62	5.00e-178	617.00
IUUC-Ete-032699	Echinops telfairi	83.57	5.00e-58	218.00
IUUC-Eca-034194	Equus caballus	94.59	5.00e-172	597.00
IUUC-Eeu-034581	Erinaceus europaeus	92.09	4.00e-160	557.00
IUUC-Fca-035744	Felis catus	95.30	3.00e-169	588.00
IUUC-Fal-037428	Ficedula albicollis	88.97	1.00e-119	423.00
IUUC-Gga-040268	Gallus gallus	89.45	3.00e-116	410.00
IUUC-Gac-042035	Gasterosteus aculeatus	86.70	4.00e-91	327.00
IUUC-Ggo-045144	Gorilla gorilla	82.99	2.00e-171	595.00
IUUC-Hsa-046953	Homo sapiens	92.32	3.00e-169	588.00
IUUC-Itr-048235	Ictidomys tridecemlineatus	90.85	2.00e-145	509.00
IUUC-Lch-049423	Latimeria chalumnae	68.23	4.00e-83	301.00
IUUC-Loc-052385	Lepisosteus oculatus	98.25	2.00e-92	332.00
IUUC-Laf-054089	Loxodonta africana	87.79	6.00e-165	573.00
IUUC-Mcc-055006	Macaca mulatta	91.51	2.00e-174	605.00
IUUC-Meu-056340	Macropus eugenii	88.84	3.00e-164	571.00
IUUC-Mga-059191	Meleagris gallopavo	90.11	4.00e-122	431.00
IUUC-Mmr-061320	Microcebus murinus	95.64	7.00e-164	570.00
IUUC-Mdo-062414	Monodelphis domestica	81.82	1.00e-161	563.00
IUUC-Mpu-066297	Mustela putorius furo	93.32	1.00e-168	586.00
IUUC-Mlu-067775	Myotis lucifugus	93.48	7.00e-166	577.00
IUUC-Nle-069237	Nomascus leucogenys	92.01	4.00e-149	521.00
IUUC-Opr-070296	Ochotona princeps	98.10	2.00e-134	472.00
IUUC-Ont-071269	Oreochromis niloticus	96.03	1.00e-87	315.00
IUUC-Oan-073394	Ornithorhynchus anatinus	86.64	1.00e-113	402.00
IUUC-Ocu-073924	Oryctolagus cuniculus	95.65	2.00e-166	578.00
IUUC-Ola-087465	Oryzias latipes	95.97	1.00e-86	312.00
IUUC-Oga-087989	Otolemur garnettii	93.95	1.00e-173	602.00
IUUC-Oar-089920	Ovis aries	82.37	9.00e-128	450.00
IUUC-Ptr-090723	Pan troglodytes	92.32	5.00e-169	587.00
IUUC-Pan-092137	Papio anubis	92.53	1.00e-169	589.00
IUUC-Psi-093233	Pelodiscus sinensis	80.23	1.00e-108	386.00
IUUC-Pfo-096965	Poecilia formosa	95.15	7.00e-91	328.00
IUUC-Pca-100601	Procavia capensis	93.53	7.00e-171	593.00
IUUC-Pva-103026	Pteropus vampyrus	94.22	2.00e-133	469.00
IUUC-Rno-105705	Rattus norvegicus	94.76	0.00e+00	647.00
IUUC-Sha-107207	Sarcophilus harrisii	90.18	4.00e-169	587.00
IUUC-Sar-113184	Sorex araneus	80.92	9.00e-172	596.00
IUUC-Ssc-115994	Sus scrofa	95.97	3.00e-171	594.00
IUUC-Tgu-117118	Taeniopygia guttata	88.26	6.00e-117	414.00
IUUC-Tru-118573	Takifugu rubripes	95.30	3.00e-87	315.00
IUUC-Tsy-119070	Tarsius syrichta	94.74	3.00e-166	578.00
IUUC-Tni-119814	Tetraodon nigroviridis	95.30	6.00e-87	313.00
IUUC-Tbe-127969	Tupaia belangeri	81.24	3.00e-151	528.00
IUUC-Ttr-128207	Tursiops truncatus	88.05	4.00e-154	538.00
IUUC-Vpa-130522	Vicugna pacos	94.74	3.00e-167	581.00
IUUC-Xtr-131894	Xenopus tropicalis	71.09	8.00e-89	319.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence