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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046927
UUCD1 version UUC-HoS-01110
Ensembl Protein ID ENSP00000255304.4
UniProt Accession Q5W0Q7; Q14109; Q6AI45; Q8IY30; Q8IYE8; USPL1_HUMAN
Genbank Protein ID CAA41848.1; CAH10469.1; AAH36027.1; AAH38103.1
Protein Name SUMO-specific isopeptidase USPL1; Ubiquitin-specific peptidase-like protein 1
Genbank Nucleotide ID X59131; CR627370; AL138681; BC038103
Gene Name USPL1; C13orf22; D13S106
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000132952.11 ENST00000255304.8 ENSP00000255304.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 19615732
Organism Homo sapiens
Functional Description
(View)

Functional Description


     SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms. May have non-catalytic functions in Cajal bodies organization and cell proliferation.
 SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms. May have non-catalytic functions in Cajal bodies organization and cell proliferation.
Protein Sequence
(Fasta)
MMDSPKIGNG LPVIGPGTDI GISSLHMVGY LGKNFDSAKV PSDEYCPACR EKGKLKALKT 60
YRISFQESIF LCEDLQCIYP LGSKSLNNLI SPDLEECHTP HKPQKRKSLE SSYKDSLLLA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046927|DUB,USP|Homo sapiens
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Nucleotide Sequence
(Fasta)
CCCAAACCCA GCCACTCACA CATGGCGGGC TCAGCAGCCA CCGGCCCCGC CCCTCCTCGT 60
CGCCGCAGTC GCAACTGCGT CTGCGGCCAC AGGGCGGACA GCCACGCCTC TGCGGAGGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046927|DUB,USP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
Interpro

IPR029388--DUF4650
IPR028890--Peptidase_C98
IPR028889--USP_dom
IPR033505--USPL1
PROSITE

PS50235--USP_3
Pfam

PF15509--DUF4650
PF15499--Peptidase_C98
Gene Ontology

GO:0015030--C:Cajal body
GO:0005615--C:extracellular space
GO:0032183--F:SUMO binding
GO:0070140--F:SUMO-specific isopeptidase activity
GO:0030576--P:Cajal body organization
GO:0008283--P:cell proliferation
GO:0016926--P:protein desumoylation
KEGG hsa:10208
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002352 Ailuropoda melanoleuca 75.00 0.00e+00 1577.00
IUUC-Apl-003844 Anas platyrhynchos 37.13 3.00e-168 586.00
IUUC-Aca-004352 Anolis carolinensis 36.31 5.00e-18 87.00
IUUC-Aly-005428 Arabidopsis lyrata 32.93 8.00e-03 35.40
IUUC-Acl-008366 Aspergillus clavatus 29.55 6.80e-02 32.30
IUUC-Afu-008770 Aspergillus fumigatus 28.68 5.40e-02 32.70
IUUC-Ame-011600 Astyanax mexicanus 33.65 2.00e-66 247.00
IUUC-Bta-012500 Bos taurus 70.38 0.00e+00 1454.00
IUUC-Bol-015346 Brassica oleracea 31.91 7.00e-03 35.80
IUUC-Cja-019507 Callithrix jacchus 89.10 0.00e+00 1479.00
IUUC-Cfa-020417 Canis familiaris 72.00 0.00e+00 1518.00
IUUC-Cpo-021840 Cavia porcellus 66.05 0.00e+00 763.00
IUUC-Csa-023677 Chlorocebus sabaeus 94.15 0.00e+00 1937.00
IUUC-Cho-024641 Choloepus hoffmanni 61.46 0.00e+00 776.00
IUUC-Csv-026246 Ciona savignyi 33.69 3.00e-38 152.00
IUUC-Dre-028578 Danio rerio 35.46 3.00e-62 234.00
IUUC-Dno-029810 Dasypus novemcinctus 71.00 0.00e+00 1314.00
IUUC-Dor-030531 Dipodomys ordii 61.96 0.00e+00 748.00
IUUC-Ete-032413 Echinops telfairi 57.41 2.00e-147 516.00
IUUC-Eca-033314 Equus caballus 76.05 0.00e+00 1568.00
IUUC-Eeu-034679 Erinaceus europaeus 68.31 0.00e+00 1397.00
IUUC-Fca-035550 Felis catus 71.97 0.00e+00 1476.00
IUUC-Fal-037362 Ficedula albicollis 38.80 1.00e-142 500.00
IUUC-Fox-037896 Fusarium oxysporum 27.08 2.30e-01 30.40
IUUC-Gmo-039391 Gadus morhua 36.50 8.00e-70 258.00
IUUC-Gga-040792 Gallus gallus 38.84 2.00e-144 506.00
IUUC-Gac-041961 Gasterosteus aculeatus 36.79 6.00e-76 278.00
IUUC-Ggo-045519 Gorilla gorilla 98.63 0.00e+00 2058.00
IUUC-Itr-048559 Ictidomys tridecemlineatus 73.52 0.00e+00 1434.00
IUUC-Lch-049826 Latimeria chalumnae 37.63 3.00e-132 466.00
IUUC-Loc-052135 Lepisosteus oculatus 41.10 2.00e-97 350.00
IUUC-Laf-054055 Loxodonta africana 70.09 0.00e+00 1438.00
IUUC-Mcc-054907 Macaca mulatta 94.42 0.00e+00 1939.00
IUUC-Meu-056740 Macropus eugenii 80.26 1.00e-30 128.00
IUUC-Mga-059291 Meleagris gallopavo 35.79 9.00e-159 554.00
IUUC-Mmr-061451 Microcebus murinus 79.25 0.00e+00 1664.00
IUUC-Mdo-062677 Monodelphis domestica 52.33 0.00e+00 745.00
IUUC-Mmu-063317 Mus musculus 59.73 0.00e+00 1153.00
IUUC-Mpu-066879 Mustela putorius furo 71.79 0.00e+00 1120.00
IUUC-Mlu-068012 Myotis lucifugus 68.37 0.00e+00 1343.00
IUUC-Nfi-068469 Neosartorya fischeri 28.57 2.00e-01 30.80
IUUC-Nle-070067 Nomascus leucogenys 95.61 0.00e+00 1957.00
IUUC-Opr-070918 Ochotona princeps 59.68 0.00e+00 1097.00
IUUC-Ont-072559 Oreochromis niloticus 37.11 2.00e-73 271.00
IUUC-Oan-073530 Ornithorhynchus anatinus 52.16 1.00e-149 524.00
IUUC-Ocu-074949 Oryctolagus cuniculus 68.48 0.00e+00 1332.00
IUUC-Obr-076717 Oryza brachyantha 36.54 1.10e-02 35.00
IUUC-Ola-086887 Oryzias latipes 38.33 6.00e-68 252.00
IUUC-Oga-087975 Otolemur garnettii 83.21 0.00e+00 903.00
IUUC-Oar-089863 Ovis aries 70.76 0.00e+00 1460.00
IUUC-Ptr-091090 Pan troglodytes 98.63 0.00e+00 2058.00
IUUC-Pan-092097 Papio anubis 93.88 0.00e+00 1927.00
IUUC-Psi-093839 Pelodiscus sinensis 41.96 0.00e+00 656.00
IUUC-Pfo-097323 Poecilia formosa 40.11 4.00e-70 260.00
IUUC-Pab-097559 Pongo abelii 97.37 0.00e+00 1280.00
IUUC-Pva-102876 Pteropus vampyrus 63.84 0.00e+00 1260.00
IUUC-Ptt-103830 Puccinia triticina 26.09 2.00e-02 32.00
IUUC-Rno-105019 Rattus norvegicus 58.63 0.00e+00 1172.00
IUUC-Sha-106836 Sarcophilus harrisii 50.62 0.00e+00 917.00
IUUC-Sar-113217 Sorex araneus 61.10 0.00e+00 1200.00
IUUC-Ssc-115551 Sus scrofa 69.74 0.00e+00 872.00
IUUC-Tgu-117236 Taeniopygia guttata 43.19 3.00e-125 443.00
IUUC-Tru-118150 Takifugu rubripes 35.19 1.00e-76 280.00
IUUC-Tsy-119095 Tarsius syrichta 63.23 0.00e+00 1258.00
IUUC-Tni-120489 Tetraodon nigroviridis 42.07 2.00e-63 235.00
IUUC-Tca-121210 Theobroma cacao 26.17 4.20e-02 32.00
IUUC-Tvi-122651 Trichoderma virens 26.47 1.60e-01 31.60
IUUC-Tbe-127419 Tupaia belangeri 74.09 0.00e+00 1546.00
IUUC-Ttr-128510 Tursiops truncatus 73.26 0.00e+00 1472.00
IUUC-Vpa-130671 Vicugna pacos 75.66 0.00e+00 1549.00
IUUC-Xtr-132920 Xenopus tropicalis 45.11 4.00e-84 306.00
IUUC-Xma-133446 Xiphophorus maculatus 45.93 2.00e-70 261.00
Created Date 25-Jun-2017

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