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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046231
UUCD1 version UUC-HoS-00796
Ensembl Protein ID ENSP00000272797.4
UniProt Accession Q8NBE8; Q8N9B9; Q96FT8; KLH23_HUMAN
Genbank Protein ID BAC03497.1; BAC04490.1; AAH10437.2
Protein Name Kelch-like protein 23
Genbank Nucleotide ID AK090653; AK095131; BC010437
Gene Name KLHL23
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000213160.9 ENST00000272797.8 ENSP00000272797.4
ENSG00000213160.9 ENST00000437875.1 ENSP00000394732.1
ENSG00000213160.9 ENST00000448589.1 ENSP00000400833.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
AREsitecircRNADbTRANSFACRepTar
miRNAMapmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 2.60e-15 58.2 36 102
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 2.90e-08 32.9 137 163
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvg.geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +D++l++  g  f++h++vLaa+S +F+a+f+ +++e+  k++++++++ ++ ++ l+++ Yt+++++
   Q: 36   TDITLQCPsGIIFHCHRAVLAACSNYFKAMFTADMKEKF-KNKIKLSGIHHDILEGLVNYAYTSQIEI 102
           6999*9999*****************************9.************************9976 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 2    eNclgilrfAdlydcpdLkdaaldfil 28
           +Nc+g+ +fA+ + cp+L +  ++ ++
   Q: 137  DNCIGMHSFAEFHVCPELEKESRRILC 163
           8******************99887555 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MALKGQEDYI YLFKDSTHPV DFLDAFRTFY LDGLFTDITL QCPSGIIFHC HRAVLAACSN 60
YFKAMFTADM KEKFKNKIKL SGIHHDILEG LVNYAYTSQI EITKRNVQSL LEAADLLQFL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046231|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGAAGAGAG GCGCCTGCGC TTGCGAGCTG GGCTTGTGAG TGGGGCTGCC GAGAGGGCAG 60
GCGTGGGGCG AGGCCAAAGG ACTGAACCCG CAGGAGCGTC ACGGGCGCCG GGGCGGCTGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046231|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0016567--P:protein ubiquitination
KEGG hsa:100526832; hsa:151230
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001639 Ailuropoda melanoleuca 98.39 0.00e+00 1150.00
IUUC-Apl-003948 Anas platyrhynchos 77.06 0.00e+00 855.00
IUUC-Aca-005045 Anolis carolinensis 76.88 0.00e+00 932.00
IUUC-Ame-011013 Astyanax mexicanus 62.92 0.00e+00 770.00
IUUC-Bta-013159 Bos taurus 98.21 0.00e+00 1149.00
IUUC-Cja-018886 Callithrix jacchus 99.28 0.00e+00 1159.00
IUUC-Cfa-020205 Canis familiaris 98.57 0.00e+00 1155.00
IUUC-Cpo-022295 Cavia porcellus 97.31 0.00e+00 1135.00
IUUC-Cho-025089 Choloepus hoffmanni 97.80 0.00e+00 934.00
IUUC-Dre-027681 Danio rerio 60.18 0.00e+00 741.00
IUUC-Dno-029078 Dasypus novemcinctus 97.58 0.00e+00 931.00
IUUC-Ete-033011 Echinops telfairi 86.23 0.00e+00 968.00
IUUC-Eca-033213 Equus caballus 98.75 0.00e+00 1156.00
IUUC-Fca-035884 Felis catus 98.39 0.00e+00 1153.00
IUUC-Fal-036897 Ficedula albicollis 77.26 0.00e+00 925.00
IUUC-Gmo-038594 Gadus morhua 57.55 0.00e+00 700.00
IUUC-Gga-040791 Gallus gallus 75.27 0.00e+00 928.00
IUUC-Gac-042512 Gasterosteus aculeatus 60.68 0.00e+00 741.00
IUUC-Ggo-044837 Gorilla gorilla 99.64 0.00e+00 1160.00
IUUC-Itr-048084 Ictidomys tridecemlineatus 99.10 0.00e+00 1155.00
IUUC-Lch-050412 Latimeria chalumnae 72.95 0.00e+00 898.00
IUUC-Loc-052033 Lepisosteus oculatus 68.79 0.00e+00 834.00
IUUC-Laf-053908 Loxodonta africana 98.21 0.00e+00 1150.00
IUUC-Mcc-054734 Macaca mulatta 99.82 0.00e+00 1164.00
IUUC-Meu-055982 Macropus eugenii 89.78 0.00e+00 1068.00
IUUC-Mga-059670 Meleagris gallopavo 74.60 0.00e+00 915.00
IUUC-Mmr-060692 Microcebus murinus 98.57 0.00e+00 1154.00
IUUC-Mdo-062419 Monodelphis domestica 89.96 0.00e+00 1071.00
IUUC-Mmu-063752 Mus musculus 97.13 0.00e+00 1141.00
IUUC-Mpu-066515 Mustela putorius furo 98.39 0.00e+00 1154.00
IUUC-Mlu-068004 Myotis lucifugus 94.97 0.00e+00 1107.00
IUUC-Nle-069163 Nomascus leucogenys 100.00 0.00e+00 1165.00
IUUC-Opr-070823 Ochotona princeps 97.14 0.00e+00 923.00
IUUC-Ont-071629 Oreochromis niloticus 62.10 0.00e+00 751.00
IUUC-Oan-072841 Ornithorhynchus anatinus 84.95 0.00e+00 1019.00
IUUC-Ocu-074300 Oryctolagus cuniculus 98.75 0.00e+00 1156.00
IUUC-Ola-087025 Oryzias latipes 57.65 0.00e+00 713.00
IUUC-Oga-088442 Otolemur garnettii 96.89 0.00e+00 1099.00
IUUC-Oar-089237 Ovis aries 98.21 0.00e+00 1146.00
IUUC-Ptr-091541 Pan troglodytes 99.82 0.00e+00 1163.00
IUUC-Psi-093748 Pelodiscus sinensis 77.60 0.00e+00 942.00
IUUC-Pma-094302 Petromyzon marinus 45.51 1.00e-101 363.00
IUUC-Pfo-097039 Poecilia formosa 61.15 0.00e+00 728.00
IUUC-Pab-098280 Pongo abelii 99.46 0.00e+00 1157.00
IUUC-Pca-100840 Procavia capensis 89.07 0.00e+00 1022.00
IUUC-Pva-102152 Pteropus vampyrus 98.39 0.00e+00 1149.00
IUUC-Rno-105710 Rattus norvegicus 96.94 0.00e+00 1137.00
IUUC-Sha-106991 Sarcophilus harrisii 89.07 0.00e+00 1065.00
IUUC-Sar-112931 Sorex araneus 97.49 0.00e+00 1146.00
IUUC-Ssc-116016 Sus scrofa 97.32 0.00e+00 1139.00
IUUC-Tgu-116999 Taeniopygia guttata 77.06 0.00e+00 930.00
IUUC-Tsy-119071 Tarsius syrichta 98.21 0.00e+00 1147.00
IUUC-Tni-120149 Tetraodon nigroviridis 56.14 0.00e+00 653.00
IUUC-Tbe-127651 Tupaia belangeri 98.92 0.00e+00 1156.00
IUUC-Ttr-128402 Tursiops truncatus 98.57 0.00e+00 1155.00
IUUC-Vpa-130186 Vicugna pacos 96.95 0.00e+00 1135.00
IUUC-Xtr-132379 Xenopus tropicalis 71.15 0.00e+00 880.00
Created Date 25-Jun-2017

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