iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-021966

Ensembl Protein ID

ENSCPOP00000000599.2

UniProt Accession

H0UUG0; H0UUG0_CAVPO

Genbank Protein ID

ENSCPOP00000000599

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02004502

Gene Name

VAV3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000000677.3	ENSCPOT00000000682.2	ENSCPOP00000000599.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.30e-14	53.9	696	747

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+l kGdvv++   +   +gW++g  e +g+ G fP+ +ve+
   Q: 696  IARYDFCARDMRELSLLKGDVVKIY-TKMSANGWWRG--EVNGRVGWFPSTYVEE 747
           688*********************9.999999*****..9*************86 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

LIDTFLFSQV IETLSRLSRT PIALATGIRP FPTEESIDDE DIYKGLPDLI DETRVEDEED 60
LYDCVYGEDE GGEVYEDLMK AEEAHQQKSP ENDIRTCCLA EIKQTEEKYT ETLESIEKYF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTAATAGATA CTTTCCTCTT TTCCCAGGTT ATAGAAACAT TATCACGGCT TTCTCGTACA 60
CCAATAGCAT TGGCCACAGG GATCAGGTAA GCTCACTTTT TTGTGTCTCA TCTGTCACGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0050853--P:B cell receptor signaling pathway
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007229--P:integrin-mediated signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0030593--P:neutrophil chemotaxis
GO:0030890--P:positive regulation of B cell proliferation
GO:0045785--P:positive regulation of cell adhesion
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0042493--P:response to drug
GO:0007264--P:small GTPase mediated signal transduction
GO:0006906--P:vesicle fusion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001362	Ailuropoda melanoleuca	94.93	0.00e+00	1390.00
IUUC-Apl-003734	Anas platyrhynchos	86.38	0.00e+00	1287.00
IUUC-Aca-004477	Anolis carolinensis	80.69	0.00e+00	1194.00
IUUC-Ame-011279	Astyanax mexicanus	63.55	0.00e+00	916.00
IUUC-Bta-012722	Bos taurus	93.59	0.00e+00	1373.00
IUUC-Cja-018941	Callithrix jacchus	95.86	0.00e+00	1402.00
IUUC-Cfa-020266	Canis familiaris	95.33	0.00e+00	1399.00
IUUC-Csa-023892	Chlorocebus sabaeus	95.19	0.00e+00	1397.00
IUUC-Dre-028199	Danio rerio	63.08	0.00e+00	926.00
IUUC-Dno-029474	Dasypus novemcinctus	94.66	0.00e+00	1388.00
IUUC-Eca-033961	Equus caballus	95.59	0.00e+00	1432.00
IUUC-Eeu-034719	Erinaceus europaeus	75.19	0.00e+00	791.00
IUUC-Fca-036572	Felis catus	94.39	0.00e+00	1381.00
IUUC-Fal-036802	Ficedula albicollis	83.40	0.00e+00	1275.00
IUUC-Gmo-039409	Gadus morhua	66.67	0.00e+00	968.00
IUUC-Gga-040884	Gallus gallus	85.31	0.00e+00	1273.00
IUUC-Gac-041395	Gasterosteus aculeatus	68.53	0.00e+00	1046.00
IUUC-Ggo-044460	Gorilla gorilla	95.86	0.00e+00	1406.00
IUUC-Hsa-046099	Homo sapiens	92.15	0.00e+00	1385.00
IUUC-Itr-048144	Ictidomys tridecemlineatus	93.26	0.00e+00	1416.00
IUUC-Lch-049650	Latimeria chalumnae	82.16	4.00e-109	386.00
IUUC-Loc-052487	Lepisosteus oculatus	70.73	0.00e+00	1048.00
IUUC-Laf-054564	Loxodonta africana	94.13	0.00e+00	1377.00
IUUC-Mcc-054622	Macaca mulatta	91.51	0.00e+00	1376.00
IUUC-Meu-056680	Macropus eugenii	83.58	0.00e+00	1204.00
IUUC-Mga-060013	Meleagris gallopavo	81.09	0.00e+00	1202.00
IUUC-Mmr-061251	Microcebus murinus	90.08	0.00e+00	1400.00
IUUC-Mdo-061875	Monodelphis domestica	91.86	0.00e+00	1355.00
IUUC-Mmu-063735	Mus musculus	95.33	0.00e+00	1422.00
IUUC-Mpu-065856	Mustela putorius furo	94.93	0.00e+00	1387.00
IUUC-Mlu-068108	Myotis lucifugus	88.16	0.00e+00	1295.00
IUUC-Nle-069863	Nomascus leucogenys	91.38	0.00e+00	1371.00
IUUC-Opr-070372	Ochotona princeps	80.00	0.00e+00	827.00
IUUC-Ont-072286	Oreochromis niloticus	68.98	0.00e+00	1035.00
IUUC-Ocu-074194	Oryctolagus cuniculus	95.99	0.00e+00	1399.00
IUUC-Ola-086336	Oryzias latipes	68.22	0.00e+00	1034.00
IUUC-Oga-089104	Otolemur garnettii	56.18	0.00e+00	811.00
IUUC-Oar-089272	Ovis aries	93.46	0.00e+00	1412.00
IUUC-Ptr-090652	Pan troglodytes	92.94	0.00e+00	1383.00
IUUC-Pan-092550	Papio anubis	91.51	0.00e+00	1377.00
IUUC-Psi-093784	Pelodiscus sinensis	79.95	0.00e+00	1194.00
IUUC-Ppa-095161	Physcomitrella patens	43.64	3.00e-09	56.20
IUUC-Pfo-097308	Poecilia formosa	67.14	0.00e+00	1034.00
IUUC-Pab-098698	Pongo abelii	92.92	0.00e+00	1384.00
IUUC-Pva-102262	Pteropus vampyrus	94.43	0.00e+00	1320.00
IUUC-Rno-105421	Rattus norvegicus	94.26	0.00e+00	1421.00
IUUC-Sha-107325	Sarcophilus harrisii	92.52	0.00e+00	1380.00
IUUC-Sar-113456	Sorex araneus	91.53	0.00e+00	1312.00
IUUC-Ssc-115338	Sus scrofa	55.66	0.00e+00	816.00
IUUC-Tgu-116595	Taeniopygia guttata	81.65	0.00e+00	1195.00
IUUC-Tru-118577	Takifugu rubripes	64.63	0.00e+00	1004.00
IUUC-Tsy-119429	Tarsius syrichta	87.05	0.00e+00	1256.00
IUUC-Tni-119951	Tetraodon nigroviridis	69.03	0.00e+00	1008.00
IUUC-Tbe-127995	Tupaia belangeri	69.65	2.00e-140	493.00
IUUC-Ttr-128281	Tursiops truncatus	94.13	0.00e+00	1378.00
IUUC-Vpa-130066	Vicugna pacos	49.32	6.00e-36	145.00
IUUC-Xtr-132427	Xenopus tropicalis	73.09	0.00e+00	1133.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence