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Tag Content
iUUCD ID IUUC-Aca-004278
Ensembl Protein ID ENSACAP00000007827.3
UniProt Accession H9GDB3; H9GDB3_ANOCA
Protein Name Histone-lysine N-methyltransferase
Gene Name WHSC1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSACAG00000007905.3 ENSACAT00000007993.3 ENSACAP00000007827.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 2.40e-14 53.2 689 729
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC +gg+    l++Ce C  +fHp+Cl+++    +p+ + w+C++C+
   Q: 689  WCFVCSKGGS----LLCCESCPAAFHPDCLNIE----MPDGS-WYCNDCK 729
           8*********....*******************....9***8.******8 PP
   
Organism Anolis carolinensis
Protein Sequence
(Fasta)
MDFKSGSLLL TKKSGNHIKM KQVPEILGNA TVKTQNCEVN RDCSVYLGKT HLSTTLQEDV 60
MPKYNGHDAL PFIPADKLKD LTSRVFNGES GTQDSKLHFE SRDIKEAGTP PNTTPIKNGS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Aca-004278|E3,PHD|Anolis carolinensis
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTTCAAAGC AGGAAATGTG GGATTTTATT CAGCTGTGTG GAAGGGGCCA GGGAGGTGTT 60
CCCAGCCCAG GCCATTTTGG AGCTCTGTGA GTGTGGGGGG GGGGGGGGGG GGTATTGGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Aca-004278|E3,PHD|Anolis carolinensis
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006560--AWS_dom
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51215--AWS
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS50089--ZF_RING_2
Pfam

PF00855--PWWP
PF00856--SET
SMART

SM00570--AWS
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00317--SET
Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0043565--F:sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0003289--P:atrial septum primum morphogenesis
GO:0003290--P:atrial septum secundum morphogenesis
GO:0060348--P:bone development
GO:0010452--P:histone H3-K36 methylation
GO:0034770--P:histone H4-K20 methylation
GO:0003149--P:membranous septum morphogenesis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048298--P:positive regulation of isotype switching to IgA isotypes
GO:2001032--P:regulation of double-strand break repair via nonhomologous end joining
GO:0070201--P:regulation of establishment of protein localization
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002181 Ailuropoda melanoleuca 75.42 0.00e+00 1375.00
IUUC-Apl-003677 Anas platyrhynchos 80.25 0.00e+00 1484.00
IUUC-Ame-011932 Astyanax mexicanus 67.39 0.00e+00 1039.00
IUUC-Bta-012522 Bos taurus 74.86 0.00e+00 1339.00
IUUC-Bol-016001 Brassica oleracea 34.57 4.00e-17 84.00
IUUC-Bra-017864 Brassica rapa 33.75 2.00e-16 82.40
IUUC-Cja-018908 Callithrix jacchus 75.14 0.00e+00 1352.00
IUUC-Cfa-020894 Canis familiaris 76.33 0.00e+00 1381.00
IUUC-Cpo-021982 Cavia porcellus 74.65 0.00e+00 1375.00
IUUC-Csa-023807 Chlorocebus sabaeus 75.30 0.00e+00 1360.00
IUUC-Cho-024405 Choloepus hoffmanni 90.32 1.00e-90 327.00
IUUC-Dre-027492 Danio rerio 72.13 0.00e+00 1087.00
IUUC-Dno-030020 Dasypus novemcinctus 74.97 0.00e+00 1160.00
IUUC-Dor-031103 Dipodomys ordii 66.30 0.00e+00 1148.00
IUUC-Ete-032488 Echinops telfairi 69.65 0.00e+00 1207.00
IUUC-Eca-034066 Equus caballus 76.30 0.00e+00 1392.00
IUUC-Eeu-035199 Erinaceus europaeus 56.70 7.00e-176 611.00
IUUC-Fca-035434 Felis catus 72.31 0.00e+00 1305.00
IUUC-Fal-037113 Ficedula albicollis 83.37 0.00e+00 1556.00
IUUC-Gmo-039686 Gadus morhua 66.95 0.00e+00 1008.00
IUUC-Gga-040273 Gallus gallus 81.62 0.00e+00 1528.00
IUUC-Gac-042123 Gasterosteus aculeatus 69.06 0.00e+00 1066.00
IUUC-Ggo-044643 Gorilla gorilla 75.08 0.00e+00 1385.00
IUUC-Hsa-046380 Homo sapiens 74.97 0.00e+00 1353.00
IUUC-Itr-048658 Ictidomys tridecemlineatus 79.11 0.00e+00 1239.00
IUUC-Lch-050217 Latimeria chalumnae 69.88 0.00e+00 1303.00
IUUC-Lpe-051201 Leersia perrieri 30.30 1.00e-12 67.80
IUUC-Loc-052766 Lepisosteus oculatus 69.06 0.00e+00 1159.00
IUUC-Laf-053780 Loxodonta africana 76.77 0.00e+00 1401.00
IUUC-Mcc-054928 Macaca mulatta 75.42 0.00e+00 1392.00
IUUC-Mga-059576 Meleagris gallopavo 77.35 0.00e+00 1435.00
IUUC-Mmr-061045 Microcebus murinus 74.62 0.00e+00 1405.00
IUUC-Mdo-062576 Monodelphis domestica 82.28 0.00e+00 1492.00
IUUC-Mmu-063640 Mus musculus 75.44 0.00e+00 1351.00
IUUC-Mpu-066512 Mustela putorius furo 75.19 0.00e+00 1353.00
IUUC-Nle-069896 Nomascus leucogenys 75.70 0.00e+00 1305.00
IUUC-Ont-072197 Oreochromis niloticus 74.15 0.00e+00 1044.00
IUUC-Oan-072724 Ornithorhynchus anatinus 82.90 0.00e+00 1215.00
IUUC-Ocu-074758 Oryctolagus cuniculus 74.67 0.00e+00 1331.00
IUUC-Obr-076122 Oryza brachyantha 30.36 1.00e-11 63.20
IUUC-Ogl-077641 Oryza glaberrima 28.81 5.00e-12 65.10
IUUC-Ogu-078898 Oryza glumaepatula 29.48 9.00e-12 64.30
IUUC-Oin-079557 Oryza indica 29.48 8.00e-12 64.30
IUUC-Olo-080702 Oryza longistaminata 41.47 2.00e-44 174.00
IUUC-Opu-083371 Oryza punctata 44.72 1.00e-45 178.00
IUUC-Osa-085353 Oryza sativa 28.81 5.00e-12 65.10
IUUC-Oga-088702 Otolemur garnettii 77.39 0.00e+00 1151.00
IUUC-Oar-089736 Ovis aries 71.82 0.00e+00 1192.00
IUUC-Ptr-091055 Pan troglodytes 74.75 0.00e+00 1352.00
IUUC-Pan-092752 Papio anubis 82.26 0.00e+00 1241.00
IUUC-Psi-093620 Pelodiscus sinensis 80.34 0.00e+00 1487.00
IUUC-Pfo-097464 Poecilia formosa 65.60 0.00e+00 1058.00
IUUC-Pab-098051 Pongo abelii 75.30 0.00e+00 1389.00
IUUC-Pca-100273 Procavia capensis 76.85 0.00e+00 1394.00
IUUC-Pva-102473 Pteropus vampyrus 76.26 0.00e+00 1112.00
IUUC-Rno-105056 Rattus norvegicus 75.00 0.00e+00 1379.00
IUUC-Sha-107494 Sarcophilus harrisii 82.61 0.00e+00 1494.00
IUUC-Sar-113310 Sorex araneus 76.43 0.00e+00 1237.00
IUUC-Sbi-114581 Sorghum bicolor 32.41 4.00e-09 55.10
IUUC-Ssc-116344 Sus scrofa 74.07 0.00e+00 1337.00
IUUC-Tgu-116786 Taeniopygia guttata 83.28 0.00e+00 1479.00
IUUC-Tru-117638 Takifugu rubripes 64.43 0.00e+00 1069.00
IUUC-Tsy-118937 Tarsius syrichta 79.93 0.00e+00 1302.00
IUUC-Tni-120452 Tetraodon nigroviridis 69.03 0.00e+00 1056.00
IUUC-Tae-125237 Triticum aestivum 27.40 7.00e-06 44.30
IUUC-Tbe-127291 Tupaia belangeri 70.81 0.00e+00 1263.00
IUUC-Ttr-129017 Tursiops truncatus 66.21 0.00e+00 902.00
IUUC-Xtr-132673 Xenopus tropicalis 71.08 0.00e+00 1288.00
IUUC-Xma-133695 Xiphophorus maculatus 74.25 0.00e+00 1021.00
Created Date 25-Jun-2017

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