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Tag Content
iUUCD ID IUUC-Cne-026920
Ensembl Protein ID AAW46637
UniProt Accession P0CP06; Q55MF8; Q5K8B4; NACA_CRYNJ
Genbank Protein ID AAW46637.1
Protein Name Nascent polypeptide-associated complex subunit alpha; Alpha-NAC
Genbank Nucleotide ID AE017352
Gene Name EGD2; CNL06300
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
CNL06300 AAW46637 AAW46637
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UBA 32.96 5.00e-16 78.60 IUUC-Sce-106371
UBD/Alpha-Helix/UBA 33.33 1.00e-17 84.00 IUUC-Spo-108121
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Cryptococcus neoformans
Functional Description
(View)

Functional Description


     Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation (By similarity).
 Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation (By similarity).
Protein Sequence
(Fasta)
MSIENLHIAD ETEIPAGATV ELHSRPERKA RKALEGLGLK RVQGIQRVTL RRARNVLLVV 60
SSPEVYKSPG SDCYIVFGEA KVEDPNSAAQ LQAQAQLAAS SQAAQQAHAH GGFKEGVPKS 120
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Protein Fasta Sequence


>IUUC-Cne-026920|UBD,UBA|Cryptococcus neoformans
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Nucleotide Sequence
(Fasta)
CCCCACCGCA CACACCGCCA TGTCCATCGA GAACCTCCAC ATCGCTGACG AGACCGAAAT 60
CCCCGCCGGC GCCACCGTCG AGCTCCACTC CCGCCCCGAG CGCAAGGCCA GGAAGGCTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cne-026920|UBD,UBA|Cryptococcus neoformans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
Interpro

IPR016641--EGD2/NACA
IPR002715--Nas_poly-pep-assoc_cplx_dom
PROSITE

PS51151--NAC_AB
Pfam

PF01849--NAC
SMART

SM01407--NAC
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0015031--P:protein transport
KEGG cne:CNL06300
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001167 Aegilops tauschii 34.81 2.00e-17 80.10
IUUC-Aml-001719 Ailuropoda melanoleuca 61.29 6.00e-21 95.50
IUUC-Atr-002586 Amborella trichopoda 29.31 3.00e-10 56.20
IUUC-Apl-003190 Anas platyrhynchos 37.28 2.00e-20 89.40
IUUC-Aca-005265 Anolis carolinensis 36.90 1.00e-22 97.80
IUUC-Aly-006397 Arabidopsis lyrata 34.15 1.00e-16 77.40
IUUC-Ath-006809 Arabidopsis thaliana 34.84 9.00e-16 74.70
IUUC-Ago-007936 Ashbya gossypii 29.89 1.00e-14 70.90
IUUC-Acl-008036 Aspergillus clavatus 61.43 4.00e-23 99.00
IUUC-Afl-008462 Aspergillus flavus 61.54 2.00e-25 107.00
IUUC-Afu-008832 Aspergillus fumigatus 60.94 1.00e-20 90.90
IUUC-Ani-009246 Aspergillus nidulans 61.64 5.00e-24 102.00
IUUC-Ang-009808 Aspergillus niger 61.43 5.00e-23 98.60
IUUC-Aor-009972 Aspergillus oryzae 61.54 2.00e-25 107.00
IUUC-Ame-011674 Astyanax mexicanus 61.29 1.00e-21 94.40
IUUC-Bgr-012162 Blumeria graminis 66.15 2.00e-22 96.70
IUUC-Bta-012508 Bos taurus 61.29 1.00e-21 94.40
IUUC-Bci-013643 Botrytis cinerea 64.38 7.00e-23 98.20
IUUC-Bdi-014854 Brachypodium distachyon 50.00 6.00e-15 72.00
IUUC-Bol-015681 Brassica oleracea 49.09 2.00e-15 73.60
IUUC-Bra-017540 Brassica rapa 34.59 2.00e-16 76.60
IUUC-Cel-018111 Caenorhabditis elegans 58.06 2.00e-20 89.70
IUUC-Cja-019846 Callithrix jacchus 35.48 3.00e-21 95.90
IUUC-Cfa-020429 Canis familiaris 61.29 1.00e-21 94.40
IUUC-Cpo-022542 Cavia porcellus 61.29 2.00e-21 94.00
IUUC-Cre-022679 Chlamydomonas reinhardtii 32.14 5.00e-21 91.70
IUUC-Csa-023260 Chlorocebus sabaeus 54.84 3.00e-19 89.40
IUUC-Cho-024869 Choloepus hoffmanni 41.18 7.00e-03 32.00
IUUC-Cin-025166 Ciona intestinalis 35.12 5.00e-22 95.50
IUUC-Csv-026284 Ciona savignyi 33.12 4.00e-19 84.70
IUUC-Cgl-026520 Colletotrichum gloeosporioides 67.12 2.00e-26 110.00
IUUC-Cme-027301 Cyanidioschyzon merolae 36.26 2.00e-15 73.90
IUUC-Dre-028709 Danio rerio 61.29 4.00e-21 95.10
IUUC-Dno-029786 Dasypus novemcinctus 61.29 8.00e-21 94.70
IUUC-Dor-030962 Dipodomys ordii 61.29 1.00e-21 94.00
IUUC-Dme-032061 Drosophila melanogaster 59.68 1.00e-20 91.30
IUUC-Ete-032965 Echinops telfairi 61.29 3.00e-21 92.80
IUUC-Eca-034049 Equus caballus 59.68 8.00e-21 91.70
IUUC-Eeu-034673 Erinaceus europaeus 61.29 1.00e-21 94.40
IUUC-Fca-036369 Felis catus 61.29 7.00e-21 95.10
IUUC-Fal-037006 Ficedula albicollis 61.29 1.00e-21 94.00
IUUC-Fox-037704 Fusarium oxysporum 42.13 3.00e-27 112.00
IUUC-Fso-038247 Fusarium solani 40.22 1.00e-26 110.00
IUUC-Gmo-039002 Gadus morhua 36.31 7.00e-21 91.70
IUUC-Ggr-039888 Gaeumannomyces graminis 65.79 6.00e-26 108.00
IUUC-Gga-040237 Gallus gallus 61.29 1.00e-21 94.00
IUUC-Gac-041800 Gasterosteus aculeatus 61.29 4.00e-21 94.00
IUUC-Gma-043275 Glycine max 34.32 3.00e-21 92.80
IUUC-Ggo-045163 Gorilla gorilla 34.78 3.00e-22 96.30
IUUC-Hsa-045795 Homo sapiens 61.29 9.00e-21 95.10
IUUC-Hvu-047376 Hordeum vulgare 34.81 1.00e-17 80.90
IUUC-Itr-048152 Ictidomys tridecemlineatus 61.29 1.00e-21 94.40
IUUC-Kpa-049166 Komagataella pastoris 40.00 3.00e-22 96.30
IUUC-Lch-050076 Latimeria chalumnae 61.29 1.00e-21 94.40
IUUC-Lpe-051258 Leersia perrieri 34.76 2.00e-17 80.10
IUUC-Loc-052292 Lepisosteus oculatus 61.29 3.00e-21 93.20
IUUC-Lma-053293 Leptosphaeria maculans 61.64 2.00e-25 106.00
IUUC-Laf-054393 Loxodonta africana 32.74 1.00e-20 90.90
IUUC-Mcc-054632 Macaca mulatta 61.29 1.00e-20 94.40
IUUC-Meu-056242 Macropus eugenii 61.29 1.00e-21 94.00
IUUC-Mor-057099 Magnaporthe oryzae 64.94 3.00e-26 109.00
IUUC-Mpo-057543 Magnaporthe poae 61.19 6.00e-20 88.20
IUUC-Mtr-058112 Medicago truncatula 38.10 6.00e-23 98.60
IUUC-Mla-059166 Melampsora laricipopulina 50.00 4.00e-14 68.90
IUUC-Mga-059406 Meleagris gallopavo 61.29 2.00e-21 93.60
IUUC-Mvi-060390 Microbotryum violaceum 33.14 7.00e-18 81.30
IUUC-Mmr-061569 Microcebus murinus 61.29 9.00e-22 94.70
IUUC-Mdo-062077 Monodelphis domestica 61.29 3.00e-21 95.10
IUUC-Mmu-063984 Mus musculus 61.29 8.00e-21 95.50
IUUC-Mac-065175 Musa acuminata 31.65 3.00e-18 83.20
IUUC-Mpu-066751 Mustela putorius furo 34.20 1.00e-21 97.40
IUUC-Mlu-068234 Myotis lucifugus 61.29 1.00e-21 94.40
IUUC-Nfi-068541 Neosartorya fischeri 60.94 1.00e-20 90.90
IUUC-Ncr-068830 Neurospora crassa 61.54 2.00e-25 107.00
IUUC-Nle-069126 Nomascus leucogenys 61.29 2.00e-21 93.60
IUUC-Opr-070742 Ochotona princeps 61.29 1.00e-21 94.40
IUUC-Ont-071828 Oreochromis niloticus 61.29 2.00e-21 94.00
IUUC-Oan-073462 Ornithorhynchus anatinus 61.29 2.00e-20 93.20
IUUC-Ocu-074890 Oryctolagus cuniculus 33.15 2.00e-19 90.10
IUUC-Oba-075995 Oryza barthii 34.81 2.00e-18 83.20
IUUC-Obr-076668 Oryza brachyantha 31.65 5.00e-20 88.60
IUUC-Ogl-077307 Oryza glaberrima 31.01 6.00e-19 85.10
IUUC-Ogu-078289 Oryza glumaepatula 31.01 6.00e-19 85.10
IUUC-Oin-079287 Oryza indica 34.81 2.00e-18 83.20
IUUC-Olo-080686 Oryza longistaminata 27.68 2.00e-15 73.60
IUUC-Ome-081567 Oryza meridionalis 31.01 4.00e-19 85.50
IUUC-Oni-082873 Oryza nivara 34.81 2.00e-18 83.20
IUUC-Opu-083291 Oryza punctata 33.75 5.00e-19 85.50
IUUC-Oru-085045 Oryza rufipogon 31.01 4.00e-19 85.50
IUUC-Osa-086265 Oryza sativa 31.01 6.00e-19 85.10
IUUC-Ola-087531 Oryzias latipes 61.29 1.00e-21 94.00
IUUC-Olu-087895 Ostreococcus lucimarinus 49.02 2.00e-14 68.60
IUUC-Oga-088239 Otolemur garnettii 61.29 1.00e-21 94.40
IUUC-Oar-089723 Ovis aries 61.29 4.00e-21 96.30
IUUC-Ptr-090481 Pan troglodytes 44.12 2.90e-02 33.10
IUUC-Pan-092223 Papio anubis 61.29 8.00e-21 94.00
IUUC-Psi-093588 Pelodiscus sinensis 61.29 1.00e-21 94.40
IUUC-Pma-094702 Petromyzon marinus 61.29 2.00e-21 93.20
IUUC-Pno-094927 Phaeosphaeria nodorum 63.01 2.00e-25 107.00
IUUC-Ppa-095389 Physcomitrella patens 54.84 4.00e-19 85.90
IUUC-Pfo-096744 Poecilia formosa 61.29 1.00e-21 94.00
IUUC-Pab-098044 Pongo abelii 61.29 1.00e-21 94.40
IUUC-Pop-099384 Populus trichocarpa 36.31 3.00e-26 109.00
IUUC-Pca-100355 Procavia capensis 33.33 1.00e-20 94.00
IUUC-Ppe-101786 Prunus persica 32.28 4.00e-18 82.80
IUUC-Pva-102494 Pteropus vampyrus 61.29 1.00e-21 94.40
IUUC-Pgr-103303 Puccinia graminis 64.06 2.00e-19 86.70
IUUC-Ptt-103748 Puccinia triticina 59.09 3.00e-11 59.70
IUUC-Pte-104368 Pyrenophora teres 61.64 5.00e-25 105.00
IUUC-Pyt-104542 Pyrenophora triticirepentis 63.01 2.00e-25 106.00
IUUC-Rno-105387 Rattus norvegicus 61.29 7.00e-21 95.50
IUUC-Sce-106371 Saccharomyces cerevisiae 32.77 1.00e-15 74.30
IUUC-Sha-107189 Sarcophilus harrisii 61.29 1.00e-21 94.40
IUUC-Sja-107942 Schizosaccharomyces japonicus 48.68 5.00e-15 71.60
IUUC-Spo-108121 Schizosaccharomyces pombe 33.16 2.00e-19 86.70
IUUC-Ssl-108595 Sclerotinia sclerotiorum 65.75 7.00e-25 105.00
IUUC-Smo-108783 Selaginella moellendorffii 34.18 6.00e-17 78.60
IUUC-Sit-109728 Setaria italica 32.72 3.00e-17 79.70
IUUC-Sly-110957 Solanum lycopersicum 35.62 9.00e-19 84.70
IUUC-Stu-112873 Solanum tuberosum 34.38 3.00e-17 79.70
IUUC-Sar-113668 Sorex araneus 41.18 8.00e-03 31.60
IUUC-Sbi-114223 Sorghum bicolor 34.81 5.00e-18 82.40
IUUC-Sre-115220 Sporisorium reilianum 54.65 6.00e-21 91.70
IUUC-Ssc-116119 Sus scrofa 61.29 1.00e-21 94.40
IUUC-Tgu-116528 Taeniopygia guttata 61.29 1.00e-21 94.00
IUUC-Tru-117538 Takifugu rubripes 61.29 1.00e-21 94.40
IUUC-Tsy-118855 Tarsius syrichta 41.18 5.00e-03 32.30
IUUC-Tni-120134 Tetraodon nigroviridis 61.29 1.00e-21 94.00
IUUC-Tca-121524 Theobroma cacao 32.91 1.00e-18 84.30
IUUC-Tre-121915 Trichoderma reesei 65.33 1.00e-23 100.00
IUUC-Tvi-122411 Trichoderma virens 65.22 2.00e-21 93.20
IUUC-Tae-123448 Triticum aestivum 34.81 2.00e-17 80.50
IUUC-Tur-126821 Triticum urartu 34.81 2.00e-17 80.10
IUUC-Tme-126875 Tuber melanosporum 61.76 6.00e-22 94.70
IUUC-Tbe-127759 Tupaia belangeri 56.86 6.00e-15 72.00
IUUC-Ttr-129124 Tursiops truncatus 34.09 2.00e-19 89.70
IUUC-Uma-129551 Ustilago maydis 54.65 3.00e-21 92.80
IUUC-Vda-129992 Verticillium dahliae 62.67 5.00e-24 102.00
IUUC-Vpa-130096 Vicugna pacos 59.68 3.00e-19 86.30
IUUC-Vvi-130940 Vitis vinifera 33.33 5.00e-16 75.50
IUUC-Xtr-132904 Xenopus tropicalis 36.53 2.00e-21 94.00
IUUC-Xma-133842 Xiphophorus maculatus 61.29 1.00e-21 94.40
IUUC-Yli-134485 Yarrowia lipolytica 46.67 7.00e-14 68.20
IUUC-Zma-135748 Zea mays 34.18 1.00e-17 80.90
Created Date 25-Jun-2017

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