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Tag Content
UUCD2 ID IUUC-Xtr-132559
UUCD1 version UUC-XeT-00631
Ensembl Protein ID ENSXETP00000014654.2
UniProt Accession F7B7S7; F7B7S7_XENTR
Genbank Protein ID ENSXETP00000014654
Protein Name Apoptotic protease-activating factor 1
Genbank Nucleotide ID AAMC01063201
Gene Name apaf1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSXETG00000006695.2 ENSXETT00000014654.2 ENSXETP00000014654.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.00e-66 218.0 657 694
UBD/Beta-Prp 3.50e-99 331.9 615 777
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           H d+v c+af  d +ll+++s D ++k+W+ +tg++l+
   Q: 657  HDDEVLCCAFsADeKLLATCSADRKVKIWNAKTGKPLR 694
           9**********556********************9986 PP
   

   UBD/Beta-Prp
   S: 51   heaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgv 139
           h+++v   +fs+dg+ +++++ D+t++v+  +tg+ +  +++h+d+vl+++fs++ + l++ s+dr +++w+ +tg+ l+ + ++h + 
   Q: 615  HKDAVFHACFSSDGQRIASCGADKTLQVFKSETGEKLLEIEAHDDEVLCCAFSADEKLLATCSADRKVKIWNAKTGKPLR-VYEEHIEQ 702
           77777777788887788888888888888888888888888888888888888877777788888888888888888877.66666666 PP
   S: 140  vncvvvhp.dg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtge 213
           vnc ++    +  ll+++s+D  ++lW+++ + +  tl g h +svy+  ++++ ++l+s s+dg++k+wd+++ +
   Q: 703  VNCCQFTNsLSaPLLATCSNDCLIKLWNSEKNYCHNTLIG-HIESVYHCRYSPDDRYLASSSMDGSLKIWDVESAN 777
           6666654414457777888888888888888888888877.88888888888877888888888888888777443 PP
   
Organism Xenopus tropicalis
Functional Description
(View)

Functional Description


     Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
 Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
Protein Sequence
(Fasta)
RMDEKARSLL LQNRTALVRD IRTAYIMDHM ISDQVITPEE EAQVKSQRTQ MDKANFLINL 60
ILGKSNQAYV SFYNALLHEG YKDLAVLLKE AANAELSDST KSSSNGITSY VKTVLCEGAV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Xtr-132559|E3,WD_repeat;UBD,Beta-Prp|Xenopus tropicalis
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAATGGATG AGAAGGCTCG GAGTCTGCTG CTTCAGAATC GAACAGCACT GGTGAGGGAC 60
ATTCGCACAG CTTACATTAT GGATCATATG ATAAGTGATC AGGTTATTAC CCCAGAGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Xtr-132559|E3,WD_repeat;UBD,Beta-Prp|Xenopus tropicalis
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR017251--Apaf-1
IPR001480--Bulb-type_lectin_dom
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0043293--C:apoptosome
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0097190--P:apoptotic signaling pathway
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001432 Ailuropoda melanoleuca 61.31 0.00e+00 1571.00
IUUC-Apl-004201 Anas platyrhynchos 60.26 0.00e+00 1561.00
IUUC-Aca-004638 Anolis carolinensis 59.06 0.00e+00 1567.00
IUUC-Ani-009285 Aspergillus nidulans 26.83 3.00e-66 247.00
IUUC-Ame-011062 Astyanax mexicanus 51.27 0.00e+00 1300.00
IUUC-Bta-012865 Bos taurus 61.53 0.00e+00 1605.00
IUUC-Cel-018376 Caenorhabditis elegans 19.82 5.00e-24 107.00
IUUC-Cja-018815 Callithrix jacchus 55.93 0.00e+00 1410.00
IUUC-Cfa-020222 Canis familiaris 58.74 0.00e+00 1462.00
IUUC-Cpo-021524 Cavia porcellus 61.18 0.00e+00 1585.00
IUUC-Csa-023861 Chlorocebus sabaeus 61.34 0.00e+00 1571.00
IUUC-Cho-024484 Choloepus hoffmanni 49.80 0.00e+00 729.00
IUUC-Dre-028006 Danio rerio 48.42 0.00e+00 1197.00
IUUC-Dno-029591 Dasypus novemcinctus 61.66 0.00e+00 1603.00
IUUC-Dor-030237 Dipodomys ordii 47.75 0.00e+00 649.00
IUUC-Ete-032620 Echinops telfairi 58.55 0.00e+00 740.00
IUUC-Eca-033569 Equus caballus 60.89 0.00e+00 1569.00
IUUC-Eeu-035354 Erinaceus europaeus 58.18 3.00e-102 366.00
IUUC-Fca-036337 Felis catus 60.97 0.00e+00 1592.00
IUUC-Fal-037077 Ficedula albicollis 60.40 0.00e+00 1565.00
IUUC-Gmo-039687 Gadus morhua 47.39 0.00e+00 885.00
IUUC-Gga-040299 Gallus gallus 59.25 0.00e+00 1560.00
IUUC-Gac-041762 Gasterosteus aculeatus 48.77 0.00e+00 1202.00
IUUC-Ggo-045563 Gorilla gorilla 61.45 0.00e+00 1576.00
IUUC-Hsa-046771 Homo sapiens 61.34 0.00e+00 1573.00
IUUC-Lch-050200 Latimeria chalumnae 59.00 0.00e+00 1483.00
IUUC-Loc-052090 Lepisosteus oculatus 55.28 0.00e+00 1408.00
IUUC-Laf-053861 Loxodonta africana 61.69 0.00e+00 1585.00
IUUC-Mcc-055543 Macaca mulatta 61.18 0.00e+00 1569.00
IUUC-Meu-056688 Macropus eugenii 60.22 0.00e+00 1535.00
IUUC-Mga-059243 Meleagris gallopavo 59.54 0.00e+00 1568.00
IUUC-Mmr-061134 Microcebus murinus 57.67 0.00e+00 1335.00
IUUC-Mdo-062913 Monodelphis domestica 60.46 0.00e+00 1570.00
IUUC-Mmu-063811 Mus musculus 60.54 0.00e+00 1577.00
IUUC-Mpu-066780 Mustela putorius furo 61.53 0.00e+00 1572.00
IUUC-Mlu-067276 Myotis lucifugus 61.72 0.00e+00 1607.00
IUUC-Nle-069129 Nomascus leucogenys 61.10 0.00e+00 1561.00
IUUC-Opr-071007 Ochotona princeps 45.16 0.00e+00 702.00
IUUC-Ont-071348 Oreochromis niloticus 51.19 0.00e+00 1322.00
IUUC-Oan-072717 Ornithorhynchus anatinus 61.07 0.00e+00 1617.00
IUUC-Ocu-074286 Oryctolagus cuniculus 60.42 0.00e+00 1327.00
IUUC-Ola-086895 Oryzias latipes 47.57 0.00e+00 1137.00
IUUC-Oga-088678 Otolemur garnettii 60.78 0.00e+00 1563.00
IUUC-Oar-089359 Ovis aries 61.77 0.00e+00 1597.00
IUUC-Ptr-091062 Pan troglodytes 61.42 0.00e+00 1574.00
IUUC-Pan-092528 Papio anubis 66.62 0.00e+00 1023.00
IUUC-Psi-093430 Pelodiscus sinensis 61.12 0.00e+00 1584.00
IUUC-Pma-094690 Petromyzon marinus 38.22 1.00e-146 513.00
IUUC-Pfo-097204 Poecilia formosa 48.85 0.00e+00 1245.00
IUUC-Pab-097690 Pongo abelii 61.50 0.00e+00 1581.00
IUUC-Pca-100778 Procavia capensis 47.26 0.00e+00 752.00
IUUC-Pva-102870 Pteropus vampyrus 60.33 0.00e+00 1449.00
IUUC-Rno-104889 Rattus norvegicus 59.90 0.00e+00 1533.00
IUUC-Sha-107465 Sarcophilus harrisii 60.35 0.00e+00 1580.00
IUUC-Sar-113268 Sorex araneus 58.97 1.00e-120 427.00
IUUC-Ssc-115654 Sus scrofa 60.62 0.00e+00 1598.00
IUUC-Tgu-117302 Taeniopygia guttata 60.16 0.00e+00 1570.00
IUUC-Tru-118363 Takifugu rubripes 50.16 0.00e+00 1280.00
IUUC-Tsy-119007 Tarsius syrichta 59.03 0.00e+00 1507.00
IUUC-Tni-120910 Tetraodon nigroviridis 49.47 0.00e+00 1233.00
IUUC-Tbe-127413 Tupaia belangeri 50.55 0.00e+00 903.00
IUUC-Ttr-129213 Tursiops truncatus 56.63 0.00e+00 1425.00
IUUC-Vpa-130146 Vicugna pacos 56.81 0.00e+00 1083.00
Created Date 25-Jun-2017

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