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Tag Content
UUCD2 ID IUUC-Mcc-055690
UUCD1 version UUC-MaM-00955
Ensembl Protein ID ENSMMUP00000017066.2
UniProt Accession F7HR90; F7HR90_MACMU
Genbank Protein ID AFE80151.1; AFH34020.1; EHH14724.1
Protein Name E3 ubiquitin-protein ligase HECTD3
Genbank Nucleotide ID JSUE03001266; JU477216; CM001253
Gene Name HECTD3; EGK_00692
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMMUG00000012993.3 ENSMMUT00000018229.3 ENSMMUP00000017066.2
ENSMMUG00000012993.3 ENSMMUT00000061103.1 ENSMMUP00000042251.1
ENSMMUG00000012993.3 ENSMMUT00000066100.1 ENSMMUP00000053126.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 4.60e-76 257.5 527 853
Active Site
Position(s) Description Evidence
823 Glycyl thioester intermediate {ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 8    rlevefvgEegldlgGvtreflallskelqnpd......lglflysendketlqpnpdsglknp..ehlklFeflGrllgkalqdgrll 88
            +e++f  E  +d+gG +r+ la +s+el+ ++      l++f++++n+ + +  ++d+++ np  + +  +e++G+l+g al+ +++l
   Q: 527  WWECKFIAEGIIDQGGGFRDSLADMSEELCPSSadtpvpLPFFVRTANQGNGTGEARDMYVPNPscRDFAKYEWIGQLMGAALRGKEFL 615
           355*****************************9999*99**********************9999999********************* PP
   S: 89   dlplsksfyklllgkklsl.edleevdpelykslkeikenaesdieelgldltfsvseei...lgetkeeeLkpgGenipVtneNkeeY 173
            l l+ +++k+l g+++s+ +d+++vd+ l+k l+ ++      +++++++++f ++ +    l++++++eL+pgG+ i V + +++++
   Q: 616  VLALPGFVWKQLSGEEVSWsKDFPAVDSVLVKLLEVMEG-----MDKETFEFKFGKELTFttvLSDQQVVELIPGGAGIIVGYGDRSRF 699
           **************************************5.....56666777777443334449************************* PP
   S: 174  vklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           ++lv ++rl+e  keqv+a+++G+ +v+p+ +l+l+t++ele  +cG++e++v++l+k t++++ ++++++ +q+Fwe+l++f++e+r+
   Q: 700  IQLVQKARLEE-SKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFED-FEPSDSRVQYFWEALNNFTNEDRS 786
           **********9.9*************************************************76.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk...dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +fL+FvTg+srlP+        r++++++   ++++d lP+s+TC ++L LP+Y s ++++ekL+yA  ++ +++
   Q: 787  RFLRFVTGRSRLPA--------RIYIYPDklgYETTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNCVAID 853
           *************5........6667777799999**********************************998776 PP
   
Organism Macaca mulatta
Protein Sequence
(Fasta)
MAGPGPGAVL ESPRQLLGRV RFLAEAARSL RAGRPLPAAL AFVPQEVLYK LYKDPAGPSR 60
VLLPVWEAEG LGLRVGAAGP APGTGSGPLR AARDSIELRR GACVRTTGEE LCNGHGLWVK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mcc-055690|E3,HECT|Macaca mulatta
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGGTGGGAA GCTCCGTCCG CGGTCGCGCC AGCTGTTCAC CGGGTAGGAT CGCCCTTAGG 60
CGCTCACCTC CGCCACTTAG CCATGGCGGG TCCTGGCCCG GGCGCGGTGC TGGAGTCCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mcc-055690|E3,HECT|Macaca mulatta
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR004939--APC_su10/DOC_dom
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
PROSITE

PS51284--DOC
PS50237--HECT
Pfam

PF03256--ANAPC10
PF00632--HECT
SMART

SM01337--APC10
SM00119--HECTc
Gene Ontology

GO:0048471--C:perinuclear region of cytoplasm
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
KEGG mcc:705051
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001229 Ailuropoda melanoleuca 97.68 0.00e+00 1671.00
IUUC-Apl-003715 Anas platyrhynchos 85.12 0.00e+00 1316.00
IUUC-Aca-004377 Anolis carolinensis 78.78 0.00e+00 1384.00
IUUC-Ame-011918 Astyanax mexicanus 64.17 0.00e+00 1117.00
IUUC-Bta-012736 Bos taurus 98.37 0.00e+00 1691.00
IUUC-Cja-019926 Callithrix jacchus 98.49 0.00e+00 1682.00
IUUC-Cfa-020753 Canis familiaris 98.44 0.00e+00 1175.00
IUUC-Cpo-021415 Cavia porcellus 97.33 0.00e+00 1664.00
IUUC-Csa-023096 Chlorocebus sabaeus 99.77 0.00e+00 1696.00
IUUC-Dre-028746 Danio rerio 69.17 0.00e+00 1196.00
IUUC-Dno-029293 Dasypus novemcinctus 97.93 0.00e+00 1073.00
IUUC-Dor-031113 Dipodomys ordii 98.36 0.00e+00 1238.00
IUUC-Ete-032601 Echinops telfairi 89.41 0.00e+00 1422.00
IUUC-Eca-034198 Equus caballus 95.70 0.00e+00 1639.00
IUUC-Eeu-034708 Erinaceus europaeus 97.32 0.00e+00 900.00
IUUC-Fca-035478 Felis catus 98.55 0.00e+00 1654.00
IUUC-Fal-037366 Ficedula albicollis 76.87 0.00e+00 1341.00
IUUC-Gmo-039020 Gadus morhua 75.46 0.00e+00 1045.00
IUUC-Gga-040332 Gallus gallus 79.48 0.00e+00 1402.00
IUUC-Gac-042336 Gasterosteus aculeatus 69.86 0.00e+00 1239.00
IUUC-Ggo-045382 Gorilla gorilla 99.77 0.00e+00 1699.00
IUUC-Hsa-046562 Homo sapiens 99.77 0.00e+00 1699.00
IUUC-Itr-048208 Ictidomys tridecemlineatus 98.26 0.00e+00 1679.00
IUUC-Lch-049606 Latimeria chalumnae 65.21 0.00e+00 838.00
IUUC-Loc-052448 Lepisosteus oculatus 62.63 0.00e+00 1069.00
IUUC-Laf-054507 Loxodonta africana 97.10 0.00e+00 1694.00
IUUC-Meu-055970 Macropus eugenii 85.02 0.00e+00 1437.00
IUUC-Mga-059654 Meleagris gallopavo 85.32 0.00e+00 1302.00
IUUC-Mmr-061069 Microcebus murinus 98.49 0.00e+00 1681.00
IUUC-Mdo-062547 Monodelphis domestica 92.20 0.00e+00 791.00
IUUC-Mmu-063096 Mus musculus 97.56 0.00e+00 1671.00
IUUC-Mpu-065846 Mustela putorius furo 97.79 0.00e+00 1684.00
IUUC-Mlu-067992 Myotis lucifugus 97.04 0.00e+00 1568.00
IUUC-Nle-069565 Nomascus leucogenys 99.75 0.00e+00 1591.00
IUUC-Opr-070853 Ochotona princeps 84.30 0.00e+00 1016.00
IUUC-Ont-071628 Oreochromis niloticus 69.36 0.00e+00 1208.00
IUUC-Ocu-074094 Oryctolagus cuniculus 98.37 0.00e+00 1680.00
IUUC-Ola-087384 Oryzias latipes 69.49 0.00e+00 1254.00
IUUC-Oga-088224 Otolemur garnettii 98.02 0.00e+00 1678.00
IUUC-Oar-090043 Ovis aries 92.22 0.00e+00 1570.00
IUUC-Ptr-090852 Pan troglodytes 99.54 0.00e+00 1691.00
IUUC-Pan-092787 Papio anubis 100.00 0.00e+00 1701.00
IUUC-Psi-092986 Pelodiscus sinensis 72.57 0.00e+00 976.00
IUUC-Pma-094416 Petromyzon marinus 40.45 2.00e-175 609.00
IUUC-Pfo-096720 Poecilia formosa 69.54 0.00e+00 1250.00
IUUC-Pab-098325 Pongo abelii 99.26 0.00e+00 1307.00
IUUC-Pca-100885 Procavia capensis 83.01 0.00e+00 1196.00
IUUC-Pva-102829 Pteropus vampyrus 86.20 0.00e+00 1054.00
IUUC-Rno-104882 Rattus norvegicus 97.79 0.00e+00 1671.00
IUUC-Sha-106811 Sarcophilus harrisii 91.04 6.00e-116 410.00
IUUC-Sar-113020 Sorex araneus 83.14 0.00e+00 707.00
IUUC-Ssc-115436 Sus scrofa 98.52 1.00e-158 552.00
IUUC-Tgu-117042 Taeniopygia guttata 79.30 0.00e+00 1391.00
IUUC-Tru-118419 Takifugu rubripes 67.21 0.00e+00 1170.00
IUUC-Tsy-118829 Tarsius syrichta 97.73 0.00e+00 989.00
IUUC-Tni-120410 Tetraodon nigroviridis 56.43 0.00e+00 925.00
IUUC-Tbe-128113 Tupaia belangeri 98.43 0.00e+00 779.00
IUUC-Ttr-128167 Tursiops truncatus 93.84 0.00e+00 1611.00
IUUC-Xtr-132910 Xenopus tropicalis 64.46 0.00e+00 1078.00
Created Date 25-Jun-2017

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