iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000042444.10	ENSMUST00000049031.5	ENSMUSP00000037035.5
ENSMUSG00000042444.10	ENSMUST00000213380.1	ENSMUSP00000150300.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	mUbiSiDa
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/MINDY	7.90e-66	220.9	251	373

Active Site

Position(s)	Description	Evidence
244	Nucleophile	{ECO:0000250\|UniProtKB:Q8N5J2}
426	Proton acceptor	{ECO:0000250\|UniProtKB:Q8N5J2}

Domain Profile

DUB/MINDY

   S: 1    nilllswkvklvpkkevitleelievlgdilldvkdkekseiselnyeqnvddalsllpklaeGldvnvrftGvrsfeytkecsvfdll 89
           n+lll+wkvkl+p++e+it+e+l+e+lgd++l++k+ke+sei+++nyeqn++da+++l+kl++GldvnvrftGvr+feyt+ec+vfdll
   Q: 251  NVLLLAWKVKLPPMMEIITAEQLMEYLGDYMLEAKPKEISEIQRVNYEQNMSDAMAILHKLQTGLDVNVRFTGVRVFEYTPECIVFDLL 339
           9**************************************************************************************** PP
   S: 90   didlyhGWlvdsqideavkavgklsyeqlveril 123
           di+lyhGWlvd+qid++vkavg++sy+qlve+i+
   Q: 340  DIPLYHGWLVDPQIDDIVKAVGNCSYNQLVEKII 373
           *********************************8 PP

Organism

Mus musculus

Functional Description
(View)

Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. Can also bind to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33' and 'Lys-63'. May play a regulatory role at the level of protein turnover.

Protein Sequence
(Fasta)

MENSPDSPQP LELGVAAGRV SPPEGRRRGG REAEDGPAGR AVDSGGQGAA AAAARSSLGD 60
PTSPSQLGCG AGSDLKDGAS SSPAASEVPS RGQHKVTASP ELAEAAAGRG SGPVGDTGTC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGACGTGC CTGGCCGAGG CCGCGCTAGG GCGCTGGAGC TGCTACAGAG CGGCTGTCAT 60
GGCGTCGGAG GCGCTTGCTG AGGAGAGCCG GCCGCGGTGT CTATAGGACC AGGGGCGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR007518--MINDY
IPR033979--MINDY_domain

Pfam

PF04424--MINDY_DUB

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0016807--F:cysteine-type carboxypeptidase activity
GO:0071795--F:K11-linked polyubiquitin binding
GO:0036435--F:K48-linked polyubiquitin binding
GO:0071796--F:K6-linked polyubiquitin binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity

KEGG

mmu:235461

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-136382	Ailuropoda melanoleuca	68.27	2.00e-147	515.00
IUUC-Apl-136387	Anas platyrhynchos	95.70	8.00e-153	533.00
IUUC-Aca-136392	Anolis carolinensis	92.19	1.00e-167	582.00
IUUC-Acl-136400	Aspergillus clavatus	29.48	8.00e-26	112.00
IUUC-Afl-136401	Aspergillus flavus	40.74	4.00e-11	63.90
IUUC-Ate-136406	Aspergillus terreus	29.90	3.00e-23	103.00
IUUC-Bta-136414	Bos taurus	74.91	0.00e+00	695.00
IUUC-Cja-136427	Callithrix jacchus	98.48	0.00e+00	643.00
IUUC-Cfa-136430	Canis familiaris	96.21	0.00e+00	638.00
IUUC-Cpo-136434	Cavia porcellus	85.71	0.00e+00	631.00
IUUC-Csa-136441	Chlorocebus sabaeus	79.79	0.00e+00	769.00
IUUC-Cho-136445	Choloepus hoffmanni	76.84	3.00e-74	271.00
IUUC-Cin-136446	Ciona intestinalis	35.71	8.00e-04	35.40
IUUC-Csv-136449	Ciona savignyi	55.69	5.00e-79	287.00
IUUC-Cgl-136450	Colletotrichum gloeosporioides	29.59	4.00e-24	107.00
IUUC-Dre-136454	Danio rerio	81.75	1.00e-178	619.00
IUUC-Dno-136459	Dasypus novemcinctus	78.14	0.00e+00	664.00
IUUC-Dor-136463	Dipodomys ordii	75.64	1.00e-107	383.00
IUUC-Ete-136469	Echinops telfairi	90.06	7.00e-160	557.00
IUUC-Eca-136473	Equus caballus	94.77	0.00e+00	632.00
IUUC-Fca-136479	Felis catus	95.69	0.00e+00	646.00
IUUC-Fal-136483	Ficedula albicollis	95.31	4.00e-151	527.00
IUUC-Fox-136484	Fusarium oxysporum	30.39	4.00e-25	109.00
IUUC-Gmo-136489	Gadus morhua	78.01	3.00e-171	594.00
IUUC-Ggr-136490	Gaeumannomyces graminis	25.39	8.00e-23	102.00
IUUC-Gga-136493	Gallus gallus	87.05	0.00e+00	633.00
IUUC-Gac-136497	Gasterosteus aculeatus	76.50	4.00e-173	600.00
IUUC-Ggo-136505	Gorilla gorilla	77.88	0.00e+00	680.00
IUUC-Hsa-136507	Homo sapiens	82.05	0.00e+00	768.00
IUUC-Lch-136517	Latimeria chalumnae	67.50	3.00e-177	615.00
IUUC-Lpe-136520	Leersia perrieri	34.25	8.00e-31	129.00
IUUC-Loc-136524	Lepisosteus oculatus	84.36	0.00e+00	637.00
IUUC-Lma-136525	Leptosphaeria maculans	34.15	1.00e-31	131.00
IUUC-Laf-136528	Loxodonta africana	96.47	5.00e-171	593.00
IUUC-Mcc-136532	Macaca mulatta	72.99	3.00e-139	488.00
IUUC-Mpo-136538	Magnaporthe poae	26.41	7.00e-22	99.40
IUUC-Mga-136545	Meleagris gallopavo	95.14	2.00e-177	615.00
IUUC-Mmr-136549	Microcebus murinus	94.74	0.00e+00	673.00
IUUC-Mdo-136553	Monodelphis domestica	72.12	0.00e+00	677.00
IUUC-Mpu-136563	Mustela putorius furo	85.33	9.00e-155	540.00
IUUC-Mlu-136568	Myotis lucifugus	81.24	0.00e+00	673.00
IUUC-Ncr-136571	Neurospora crassa	28.66	2.00e-25	111.00
IUUC-Nle-136575	Nomascus leucogenys	79.89	0.00e+00	753.00
IUUC-Oan-136584	Ornithorhynchus anatinus	91.11	9.00e-109	385.00
IUUC-Ocu-136588	Oryctolagus cuniculus	81.22	0.00e+00	694.00
IUUC-Ola-136611	Oryzias latipes	79.13	4.00e-168	584.00
IUUC-Olu-136613	Ostreococcus lucimarinus	47.83	1.00e-19	91.30
IUUC-Oga-136616	Otolemur garnettii	78.61	0.00e+00	630.00
IUUC-Oar-136622	Ovis aries	81.45	0.00e+00	690.00
IUUC-Ptr-136626	Pan troglodytes	82.05	0.00e+00	763.00
IUUC-Pan-136629	Papio anubis	77.78	0.00e+00	767.00
IUUC-Psi-136633	Pelodiscus sinensis	89.62	0.00e+00	631.00
IUUC-Pma-136636	Petromyzon marinus	59.09	2.00e-140	492.00
IUUC-Pno-136637	Phaeosphaeria nodorum	32.99	6.00e-30	126.00
IUUC-Pfo-136644	Poecilia formosa	72.83	4.00e-175	607.00
IUUC-Pab-136647	Pongo abelii	80.82	0.00e+00	759.00
IUUC-Pca-136655	Procavia capensis	96.04	4.00e-156	543.00
IUUC-Pva-136659	Pteropus vampyrus	64.21	3.00e-162	565.00
IUUC-Pte-136663	Pyrenophora teres	31.86	1.00e-28	122.00
IUUC-Pyt-136664	Pyrenophora triticirepentis	31.55	4.00e-28	120.00
IUUC-Rno-136667	Rattus norvegicus	92.85	0.00e+00	823.00
IUUC-Sce-136670	Saccharomyces cerevisiae	33.09	6.00e-28	118.00
IUUC-Sha-136674	Sarcophilus harrisii	94.66	5.00e-145	506.00
IUUC-Tgu-136696	Taeniopygia guttata	79.53	0.00e+00	637.00
IUUC-Tru-136700	Takifugu rubripes	81.59	2.00e-174	605.00
IUUC-Tsy-136704	Tarsius syrichta	95.03	0.00e+00	655.00
IUUC-Tni-136709	Tetraodon nigroviridis	79.22	1.00e-171	595.00
IUUC-Tre-136712	Trichoderma reesei	31.91	9.00e-26	110.00
IUUC-Tvi-136713	Trichoderma virens	29.35	9.00e-27	115.00
IUUC-Tbe-136721	Tupaia belangeri	91.93	2.00e-159	554.00
IUUC-Ttr-136724	Tursiops truncatus	74.24	0.00e+00	682.00
IUUC-Vda-136728	Verticillium dahliae	31.17	1.00e-24	108.00
IUUC-Vpa-136731	Vicugna pacos	96.67	0.00e+00	634.00
IUUC-Xtr-136736	Xenopus tropicalis	78.19	5.00e-174	603.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence