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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046437
UUCD1 version UUC-HoS-00577
Ensembl Protein ID ENSP00000232766.5
UniProt Accession O94889; A8K612; Q7Z3E8; Q8N125; KLH18_HUMAN
Genbank Protein ID BAB93503.1; BAF84166.1; CAD97920.1; EAW64819.1; AAH32620.1; BAA34515.1
Protein Name Kelch-like protein 18
Genbank Nucleotide ID AB062478; AK291477; BX537953; AC104447; BC032620; AB018338
Gene Name KLHL18; KIAA0795; OK/SW-cl.74
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000114648.11 ENST00000433449.5 ENSP00000407114.1
ENSG00000114648.11 ENST00000232766.5 ENSP00000232766.5
ENSG00000114648.11 ENST00000442272.1 ENSP00000392507.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTInWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 6.10e-20 73.0 38 103
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 2.50e-10 39.5 137 167
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv+l++g+ +f+ah+ivLaas ++F+a+f++++ e k ++++++++++p++++al++F Y g l +
   Q: 38   CDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECK-QDEIVMQGMDPSALEALINFAYNGNLAI 103
           9*************************************.************************9865 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           + Nclg+++fA+++ c  L+daa++fi++hF
   Q: 137  PKNCLGVRQFAETMMCAVLYDAANSFIHQHF 167
           68***************************** PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MVEDGAEELE DLVHFSVSEL PSRGYGVMEE IRRQGKLCDV TLKIGDHKFS AHRIVLAASI 60
PYFHAMFTND MMECKQDEIV MQGMDPSALE ALINFAYNGN LAIDQQNVQS LLMGASFLQL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046437|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTGTCTAGC CGGCCGGCGA GGCCTGCGCA GTTGCAGCGG CCGGGGAAGA TGGTGGAGGA 60
CGGCGCGGAG GAGCTGGAGG ATCTGGTGCA CTTCTCCGTG TCTGAGTTGC CTAGTCGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046437|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0016567--P:protein ubiquitination
KEGG hsa:23276
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001536 Ailuropoda melanoleuca 97.56 0.00e+00 1164.00
IUUC-Apl-003270 Anas platyrhynchos 89.08 0.00e+00 986.00
IUUC-Aca-005395 Anolis carolinensis 90.27 0.00e+00 1078.00
IUUC-Bta-013481 Bos taurus 95.85 0.00e+00 1149.00
IUUC-Cel-018622 Caenorhabditis elegans 44.48 2.00e-140 492.00
IUUC-Cja-019847 Callithrix jacchus 99.30 0.00e+00 1189.00
IUUC-Cfa-020341 Canis familiaris 96.86 0.00e+00 1155.00
IUUC-Cpo-021613 Cavia porcellus 95.90 0.00e+00 1070.00
IUUC-Csa-023611 Chlorocebus sabaeus 99.48 0.00e+00 1187.00
IUUC-Cho-024605 Choloepus hoffmanni 81.27 2.00e-136 479.00
IUUC-Cin-025289 Ciona intestinalis 54.23 0.00e+00 639.00
IUUC-Dre-028248 Danio rerio 83.54 0.00e+00 1016.00
IUUC-Dno-029609 Dasypus novemcinctus 95.99 0.00e+00 1149.00
IUUC-Dor-030541 Dipodomys ordii 97.66 1.00e-151 529.00
IUUC-Dme-032107 Drosophila melanogaster 54.77 0.00e+00 652.00
IUUC-Eca-033507 Equus caballus 97.56 0.00e+00 1083.00
IUUC-Eeu-034750 Erinaceus europaeus 88.51 0.00e+00 966.00
IUUC-Fca-035731 Felis catus 97.39 0.00e+00 1165.00
IUUC-Fal-036959 Ficedula albicollis 89.89 0.00e+00 1041.00
IUUC-Gga-040166 Gallus gallus 91.71 0.00e+00 1090.00
IUUC-Ggo-044853 Gorilla gorilla 99.65 0.00e+00 1189.00
IUUC-Itr-048529 Ictidomys tridecemlineatus 96.46 0.00e+00 1056.00
IUUC-Lch-050195 Latimeria chalumnae 77.99 0.00e+00 905.00
IUUC-Loc-051787 Lepisosteus oculatus 86.22 0.00e+00 989.00
IUUC-Laf-053489 Loxodonta africana 96.69 0.00e+00 1162.00
IUUC-Mcc-055250 Macaca mulatta 98.62 0.00e+00 1181.00
IUUC-Meu-056871 Macropus eugenii 87.88 0.00e+00 1025.00
IUUC-Mga-059425 Meleagris gallopavo 91.71 0.00e+00 1085.00
IUUC-Mmr-061394 Microcebus murinus 97.24 0.00e+00 1167.00
IUUC-Mdo-062285 Monodelphis domestica 94.30 0.00e+00 1110.00
IUUC-Mmu-063975 Mus musculus 97.58 0.00e+00 1169.00
IUUC-Mpu-066369 Mustela putorius furo 97.91 0.00e+00 1166.00
IUUC-Mlu-067832 Myotis lucifugus 93.64 0.00e+00 1050.00
IUUC-Nle-069338 Nomascus leucogenys 92.01 0.00e+00 1068.00
IUUC-Opr-071035 Ochotona princeps 84.75 0.00e+00 921.00
IUUC-Ont-071440 Oreochromis niloticus 82.30 0.00e+00 967.00
IUUC-Ola-087275 Oryzias latipes 80.94 0.00e+00 955.00
IUUC-Oga-087921 Otolemur garnettii 98.26 0.00e+00 1173.00
IUUC-Oar-089968 Ovis aries 88.95 0.00e+00 1023.00
IUUC-Ptr-091272 Pan troglodytes 99.65 0.00e+00 1189.00
IUUC-Pan-092629 Papio anubis 99.65 0.00e+00 1191.00
IUUC-Psi-093456 Pelodiscus sinensis 93.06 0.00e+00 983.00
IUUC-Pma-094509 Petromyzon marinus 69.03 0.00e+00 792.00
IUUC-Pfo-096450 Poecilia formosa 79.12 0.00e+00 960.00
IUUC-Pab-097917 Pongo abelii 99.48 0.00e+00 1187.00
IUUC-Pop-099153 Populus trichocarpa 32.76 6.00e-35 142.00
IUUC-Pca-100330 Procavia capensis 97.32 2.00e-174 605.00
IUUC-Pva-103189 Pteropus vampyrus 97.91 0.00e+00 1169.00
IUUC-Pyt-104758 Pyrenophora triticirepentis 33.75 9.00e-07 47.00
IUUC-Sha-107283 Sarcophilus harrisii 94.11 0.00e+00 1073.00
IUUC-Sar-112989 Sorex araneus 95.86 0.00e+00 1061.00
IUUC-Tgu-117146 Taeniopygia guttata 81.06 0.00e+00 905.00
IUUC-Tru-118132 Takifugu rubripes 81.85 0.00e+00 947.00
IUUC-Tsy-119058 Tarsius syrichta 81.27 8.00e-138 483.00
IUUC-Tni-120892 Tetraodon nigroviridis 79.47 0.00e+00 951.00
IUUC-Tbe-127347 Tupaia belangeri 95.12 0.00e+00 1132.00
IUUC-Ttr-128343 Tursiops truncatus 74.58 0.00e+00 770.00
IUUC-Vpa-130796 Vicugna pacos 84.49 0.00e+00 972.00
IUUC-Xtr-132077 Xenopus tropicalis 82.48 0.00e+00 940.00
Created Date 25-Jun-2017

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