iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ggo-045124

Ensembl Protein ID

ENSGGOP00000022252.1

UniProt Accession

G3S2F4; G3S2F4_GORGO

Protein Name

Histone-lysine N-methyltransferase

Gene Name

KMT2A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000000946.2	ENSGGOT00000026025.1	ENSGGOP00000022252.1
ENSGGOG00000000946.2	ENSGGOT00000000957.2	ENSGGOP00000000936.2
ENSGGOG00000000946.2	ENSGGOT00000029098.1	ENSGGOP00000021679.1
ENSGGOG00000000946.2	ENSGGOT00000022288.1	ENSGGOP00000017220.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.90e-15	57.2	1529	1588

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedek...slveCekCrewfHpaClkls.....veeelpnsekwiCpkCrs 53
           ++C++C+++++d++   ++++C kC++w+H +C +ls     + ++lp+s +++C +C++
   Q: 1529 NFCPLCDKCYDDDDyesKMMQCGKCDRWVHSKCENLSdemyeILSNLPESVAYTCVNCTE 1588
           79***********8888*****************************************86 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

KLLSRAVRFP ARPGNVCNRP LGAQGCRRPG SLRLHPPRSP RPLPLSPEPA LCSGLPGFLP 60
PSFSRAMPLP EGGACSYPGG SSGAGVPGGA AAASAASSSS ASSSSSSSSS ASSGPALLRV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGCTGCTCT CCCGGGCGGT TCGATTCCCA GCGCGTCCCG GGAACGTGTG TAATCGGCCT 60
CTCGGCGCTC AAGGCTGCAG GCGGCCCGGC TCCCTCCGCC TCCATCCTCC GCGTAGTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50014--BROMODOMAIN_2
PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00297--BROMO
SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0005829--C:cytosol
GO:0071339--C:MLL1 complex
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0045322--F:unmethylated CpG binding
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0032922--P:circadian regulation of gene expression
GO:0060216--P:definitive hemopoiesis
GO:0006306--P:DNA methylation
GO:0035162--P:embryonic hemopoiesis
GO:0035640--P:exploration behavior
GO:0044648--P:histone H3-K4 dimethylation
GO:0080182--P:histone H3-K4 trimethylation
GO:0043984--P:histone H4-K16 acetylation
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0008285--P:negative regulation of cell proliferation
GO:0018026--P:peptidyl-lysine monomethylation
GO:2001040--P:positive regulation of cellular response to drug
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032411--P:positive regulation of transporter activity
GO:0009791--P:post-embryonic development
GO:0006461--P:protein complex assembly
GO:0071440--P:regulation of histone H3-K14 acetylation
GO:1901674--P:regulation of histone H3-K27 acetylation
GO:2000615--P:regulation of histone H3-K9 acetylation
GO:0048172--P:regulation of short-term neuronal synaptic plasticity
GO:0048536--P:spleen development
GO:0008542--P:visual learning

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001054	Aegilops tauschii	35.90	1.00e-12	68.60
IUUC-Aml-002274	Ailuropoda melanoleuca	91.35	0.00e+00	5840.00
IUUC-Atr-002455	Amborella trichopoda	48.10	8.00e-39	155.00
IUUC-Apl-003478	Anas platyrhynchos	79.25	0.00e+00	3454.00
IUUC-Aca-005086	Anolis carolinensis	64.20	0.00e+00	2704.00
IUUC-Aly-006448	Arabidopsis lyrata	48.10	4.00e-39	157.00
IUUC-Ath-006690	Arabidopsis thaliana	47.40	4.00e-37	150.00
IUUC-Bta-012974	Bos taurus	90.86	0.00e+00	5749.00
IUUC-Bol-016540	Brassica oleracea	48.05	1.00e-37	151.00
IUUC-Cja-019226	Callithrix jacchus	94.19	0.00e+00	5963.00
IUUC-Cfa-021049	Canis familiaris	91.20	0.00e+00	5767.00
IUUC-Cpo-021459	Cavia porcellus	92.68	0.00e+00	4053.00
IUUC-Cre-022891	Chlamydomonas reinhardtii	50.00	2.00e-38	156.00
IUUC-Csa-023434	Chlorocebus sabaeus	95.06	0.00e+00	5489.00
IUUC-Cho-024652	Choloepus hoffmanni	90.31	0.00e+00	3913.00
IUUC-Cin-025724	Ciona intestinalis	54.46	2.00e-96	347.00
IUUC-Cme-027224	Cyanidioschyzon merolae	34.18	3.00e-12	67.40
IUUC-Dre-028180	Danio rerio	66.41	0.00e+00	961.00
IUUC-Dno-029068	Dasypus novemcinctus	87.46	0.00e+00	5455.00
IUUC-Dor-030550	Dipodomys ordii	87.27	0.00e+00	3773.00
IUUC-Ete-032834	Echinops telfairi	84.92	0.00e+00	2797.00
IUUC-Eca-033615	Equus caballus	91.96	0.00e+00	5682.00
IUUC-Eeu-035136	Erinaceus europaeus	92.57	0.00e+00	1146.00
IUUC-Fca-036453	Felis catus	91.43	0.00e+00	2680.00
IUUC-Fal-037256	Ficedula albicollis	78.15	0.00e+00	3472.00
IUUC-Gmo-038641	Gadus morhua	65.23	0.00e+00	909.00
IUUC-Gga-040828	Gallus gallus	78.41	0.00e+00	3420.00
IUUC-Gac-041452	Gasterosteus aculeatus	70.04	0.00e+00	978.00
IUUC-Gma-043554	Glycine max	49.02	4.00e-38	153.00
IUUC-Hsa-046143	Homo sapiens	96.04	0.00e+00	5992.00
IUUC-Itr-049024	Ictidomys tridecemlineatus	88.75	0.00e+00	4982.00
IUUC-Lch-049704	Latimeria chalumnae	59.98	0.00e+00	3524.00
IUUC-Loc-052181	Lepisosteus oculatus	75.85	0.00e+00	1120.00
IUUC-Laf-053946	Loxodonta africana	90.99	0.00e+00	5572.00
IUUC-Mcc-055508	Macaca mulatta	95.43	0.00e+00	5952.00
IUUC-Meu-056485	Macropus eugenii	81.74	0.00e+00	3023.00
IUUC-Mtr-058327	Medicago truncatula	41.96	4.00e-39	156.00
IUUC-Mga-059943	Meleagris gallopavo	74.51	0.00e+00	3197.00
IUUC-Mmr-061178	Microcebus murinus	94.64	0.00e+00	4203.00
IUUC-Mdo-063031	Monodelphis domestica	85.25	0.00e+00	3786.00
IUUC-Mmu-063650	Mus musculus	88.61	0.00e+00	3851.00
IUUC-Mpu-066495	Mustela putorius furo	90.26	0.00e+00	3867.00
IUUC-Mlu-068045	Myotis lucifugus	82.69	0.00e+00	5135.00
IUUC-Nle-069064	Nomascus leucogenys	95.56	0.00e+00	6006.00
IUUC-Opr-071043	Ochotona princeps	84.39	0.00e+00	4127.00
IUUC-Ont-072556	Oreochromis niloticus	67.02	0.00e+00	953.00
IUUC-Oan-073324	Ornithorhynchus anatinus	81.19	0.00e+00	1137.00
IUUC-Ocu-074190	Oryctolagus cuniculus	90.97	0.00e+00	5620.00
IUUC-Oba-075647	Oryza barthii	49.36	3.00e-38	154.00
IUUC-Olo-080577	Oryza longistaminata	47.71	7.00e-36	145.00
IUUC-Ome-081214	Oryza meridionalis	49.36	3.00e-38	154.00
IUUC-Oni-083000	Oryza nivara	49.36	3.00e-38	154.00
IUUC-Opu-083842	Oryza punctata	49.36	3.00e-38	154.00
IUUC-Oru-084361	Oryza rufipogon	49.36	3.00e-38	154.00
IUUC-Ola-087176	Oryzias latipes	63.42	0.00e+00	951.00
IUUC-Oga-088208	Otolemur garnettii	91.30	0.00e+00	5675.00
IUUC-Oar-090152	Ovis aries	90.63	0.00e+00	5758.00
IUUC-Ptr-091127	Pan troglodytes	96.12	0.00e+00	5962.00
IUUC-Pan-092679	Papio anubis	95.31	0.00e+00	4736.00
IUUC-Psi-094059	Pelodiscus sinensis	76.91	0.00e+00	4762.00
IUUC-Pma-094258	Petromyzon marinus	60.30	0.00e+00	681.00
IUUC-Pfo-096536	Poecilia formosa	65.54	0.00e+00	936.00
IUUC-Pab-098262	Pongo abelii	95.73	0.00e+00	6041.00
IUUC-Pca-100358	Procavia capensis	88.31	0.00e+00	3798.00
IUUC-Pva-102522	Pteropus vampyrus	85.24	0.00e+00	4474.00
IUUC-Rno-105200	Rattus norvegicus	85.65	0.00e+00	3787.00
IUUC-Sha-107174	Sarcophilus harrisii	82.79	0.00e+00	5115.00
IUUC-Smo-109164	Selaginella moellendorffii	51.95	1.00e-40	162.00
IUUC-Sly-111176	Solanum lycopersicum	48.37	5.00e-36	146.00
IUUC-Stu-112529	Solanum tuberosum	48.37	2.00e-38	154.00
IUUC-Sar-113503	Sorex araneus	82.96	0.00e+00	3111.00
IUUC-Sbi-114254	Sorghum bicolor	26.92	1.00e-10	62.00
IUUC-Tgu-117047	Taeniopygia guttata	78.59	0.00e+00	3514.00
IUUC-Tsy-118953	Tarsius syrichta	89.60	0.00e+00	3105.00
IUUC-Tni-120837	Tetraodon nigroviridis	63.19	0.00e+00	946.00
IUUC-Tbe-127950	Tupaia belangeri	87.81	0.00e+00	2864.00
IUUC-Ttr-128643	Tursiops truncatus	89.66	0.00e+00	5536.00
IUUC-Vpa-130660	Vicugna pacos	91.21	0.00e+00	1861.00
IUUC-Vvi-131476	Vitis vinifera	46.75	3.00e-39	157.00
IUUC-Xtr-132869	Xenopus tropicalis	58.78	0.00e+00	2073.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence