iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
miRecords	RepTar	SomamiR	miRcode
RAID2	LncRNADisease
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/Other	E3 adaptor/Cullin RING/Other	19651607; 17392787; 21397018

Organism

Homo sapiens

Functional Description
(View)

Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.

Protein Sequence
(Fasta)

MNSSSANITY ASRKRRKPVQ KTVKPIPAEG IKSNPSKRHR DRLNTELDRL ASLLPFPQDV 60
INKLDKLSVL RLSVSYLRAK SFFDVALKSS PTERNGGQDN CRAANFREGL NLQEGEFLLQ 120

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Nucleotide Sequence
(Fasta)

ATTCAGCCGG TGCGCGCGGC GGCGGGAGGC AGTGGCTGGG GAGTCCCGTC GACGCTCTGT 60
TCCGAGAGCG TGCCCCGGAC CGCCAGCTCA GAACAGGGGC AGCCGTGTAG CCGAACGGAA 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0090--Biological rhythms
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-0675--Receptor
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR033348--AHR
IPR011598--bHLH_dom
IPR001610--PAC
IPR000014--PAS
IPR013767--PAS_fold
IPR013655--PAS_fold_3

PROSITE

PS50888--BHLH
PS50112--PAS

Pfam

PF00010--HLH
PF00989--PAS
PF08447--PAS_3

SMART

SM00353--HLH
SM00086--PAC
SM00091--PAS

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0034752--C:cytosolic aryl hydrocarbon receptor complex
GO:0034753--C:nuclear aryl hydrocarbon receptor complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005667--C:transcription factor complex
GO:0004874--F:aryl hydrocarbon receptor activity
GO:0003677--F:DNA binding
GO:0070888--F:E-box binding
GO:0035326--F:enhancer binding
GO:0051879--F:Hsp90 protein binding
GO:0046983--F:protein dimerization activity
GO:0046982--F:protein heterodimerization activity
GO:0004879--F:RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0006915--P:apoptotic process
GO:0001568--P:blood vessel development
GO:0007049--P:cell cycle
GO:0032922--P:circadian regulation of gene expression
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030888--P:regulation of B cell proliferation
GO:0010468--P:regulation of gene expression
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006355--P:regulation of transcription, DNA-templated
GO:0009636--P:response to toxic substance
GO:0009410--P:response to xenobiotic stimulus
GO:0006366--P:transcription from RNA polymerase II promoter
GO:0006805--P:xenobiotic metabolic process

KEGG

hsa:196

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002365	Ailuropoda melanoleuca	80.87	0.00e+00	1320.00
IUUC-Apl-004149	Anas platyrhynchos	64.05	0.00e+00	1032.00
IUUC-Afu-008891	Aspergillus fumigatus	25.00	4.00e-03	36.20
IUUC-Ame-010803	Astyanax mexicanus	63.48	3.00e-176	612.00
IUUC-Bta-013515	Bos taurus	79.60	0.00e+00	1334.00
IUUC-Cel-018217	Caenorhabditis elegans	34.41	2.00e-68	253.00
IUUC-Cja-019437	Callithrix jacchus	90.93	0.00e+00	1535.00
IUUC-Cfa-020030	Canis familiaris	83.45	0.00e+00	1394.00
IUUC-Cpo-021434	Cavia porcellus	76.99	0.00e+00	1251.00
IUUC-Csa-023762	Chlorocebus sabaeus	94.47	0.00e+00	1589.00
IUUC-Cho-025079	Choloepus hoffmanni	72.40	0.00e+00	985.00
IUUC-Cin-025334	Ciona intestinalis	47.84	1.00e-117	417.00
IUUC-Csv-026165	Ciona savignyi	49.46	4.00e-121	429.00
IUUC-Dre-028564	Danio rerio	66.52	3.00e-179	622.00
IUUC-Dno-029348	Dasypus novemcinctus	77.14	0.00e+00	1216.00
IUUC-Dor-030530	Dipodomys ordii	79.44	0.00e+00	1281.00
IUUC-Dme-031928	Drosophila melanogaster	45.63	3.00e-96	346.00
IUUC-Ete-032781	Echinops telfairi	73.24	0.00e+00	1187.00
IUUC-Eca-034365	Equus caballus	79.66	0.00e+00	1013.00
IUUC-Eeu-035221	Erinaceus europaeus	68.65	0.00e+00	884.00
IUUC-Fca-036147	Felis catus	77.34	0.00e+00	1149.00
IUUC-Fal-037481	Ficedula albicollis	62.37	0.00e+00	870.00
IUUC-Gmo-039418	Gadus morhua	64.22	1.00e-164	572.00
IUUC-Gga-040197	Gallus gallus	64.54	0.00e+00	989.00
IUUC-Gac-042081	Gasterosteus aculeatus	63.98	3.00e-164	572.00
IUUC-Ggo-045092	Gorilla gorilla	97.53	0.00e+00	1583.00
IUUC-Itr-047941	Ictidomys tridecemlineatus	82.39	0.00e+00	1380.00
IUUC-Lch-050097	Latimeria chalumnae	58.57	0.00e+00	831.00
IUUC-Loc-052207	Lepisosteus oculatus	52.46	0.00e+00	645.00
IUUC-Laf-053754	Loxodonta africana	78.37	0.00e+00	1274.00
IUUC-Mcc-055872	Macaca mulatta	94.47	0.00e+00	1561.00
IUUC-Meu-056345	Macropus eugenii	54.03	0.00e+00	804.00
IUUC-Mga-059612	Meleagris gallopavo	63.01	0.00e+00	969.00
IUUC-Mmr-060601	Microcebus murinus	86.21	0.00e+00	1416.00
IUUC-Mdo-062311	Monodelphis domestica	65.20	0.00e+00	709.00
IUUC-Mmu-063509	Mus musculus	71.99	0.00e+00	1098.00
IUUC-Mpu-066156	Mustela putorius furo	80.54	0.00e+00	1350.00
IUUC-Mlu-067008	Myotis lucifugus	80.14	0.00e+00	1332.00
IUUC-Nle-069602	Nomascus leucogenys	88.77	0.00e+00	1378.00
IUUC-Opr-071090	Ochotona princeps	69.87	0.00e+00	1102.00
IUUC-Oan-073251	Ornithorhynchus anatinus	61.48	0.00e+00	933.00
IUUC-Ocu-074738	Oryctolagus cuniculus	78.31	0.00e+00	1279.00
IUUC-Oga-088375	Otolemur garnettii	83.14	0.00e+00	1414.00
IUUC-Oar-089427	Ovis aries	80.42	0.00e+00	1335.00
IUUC-Ptr-091468	Pan troglodytes	98.12	0.00e+00	1614.00
IUUC-Pan-092487	Papio anubis	94.82	0.00e+00	1567.00
IUUC-Psi-093153	Pelodiscus sinensis	66.00	0.00e+00	959.00
IUUC-Pfo-097247	Poecilia formosa	50.14	3.00e-170	592.00
IUUC-Pab-097631	Pongo abelii	97.06	0.00e+00	1550.00
IUUC-Pca-100808	Procavia capensis	69.50	6.00e-135	474.00
IUUC-Pva-102999	Pteropus vampyrus	79.32	0.00e+00	1323.00
IUUC-Rno-105271	Rattus norvegicus	71.54	0.00e+00	1163.00
IUUC-Sha-107336	Sarcophilus harrisii	72.42	5.00e-177	614.00
IUUC-Sar-112972	Sorex araneus	71.54	0.00e+00	891.00
IUUC-Ssc-115783	Sus scrofa	79.57	0.00e+00	1244.00
IUUC-Tgu-116673	Taeniopygia guttata	64.48	0.00e+00	1014.00
IUUC-Tru-118052	Takifugu rubripes	62.68	0.00e+00	629.00
IUUC-Tsy-119200	Tarsius syrichta	85.68	0.00e+00	1397.00
IUUC-Tni-120507	Tetraodon nigroviridis	62.32	2.00e-180	626.00
IUUC-Tbe-127483	Tupaia belangeri	76.70	0.00e+00	1250.00
IUUC-Ttr-129070	Tursiops truncatus	78.05	0.00e+00	1248.00
IUUC-Vpa-130438	Vicugna pacos	76.84	0.00e+00	1212.00
IUUC-Xtr-131845	Xenopus tropicalis	55.13	0.00e+00	815.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence