iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-036969

Ensembl Protein ID

ENSFALP00000013510.1

UniProt Accession

U3KEQ6; U3KEQ6_FICAL

Genbank Protein ID

ENSFALP00000013510

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01011514

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000012946.1	ENSFALT00000013566.1	ENSFALP00000013510.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.90e-100	335.6	732	1055

Active Site

Position(s)	Description	Evidence
1024	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgEe++d+gGv +ef+ l+++el +p++g+f+y e+++  ++ +++      e  +lF+++G+++g+a+++  ++dl
   Q: 732  DYKKPLKVIFVGEEAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEESRLIWFSDKTF-----EDSDLFHLIGVVCGLAIYNFTIVDL 813
           78999***********************************************98877.....689********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll+kk sl+dl+e++p++ + +++++++ e+diee+ ++l+f+++ e++g+t+ +eL+p+G++ipV ++N++++v+++
   Q: 814  HFPLALYKKLLNKKPSLDDLKELMPDVGRGMQQLLDYPEDDIEEA-FCLNFTITVENFGTTEIKELVPKGADIPVVKQNRQDFVDAY 899
           ***************************************9**998.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y++++++++ + af+eGf++v+  ++l+lF+++el+ ++ G++++d+++l+k+t+ykg+y +d+p+i+ Fwev++e+s e++k+f
   Q: 900  VDYIFNRSVASLYSAFHEGFHKVCGGKVLQLFQPSELQAMVIGNTNYDWKELEKNTEYKGEYWADHPTIKIFWEVFHELSLEKKKQF 986
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G++ lk    vi+   + +d lP ++TCfn+L+LP+Y+ ke+lk+kL+ Ai++ +gF+l
   Q: 987  LLFLTGSDRIPILGMKCLK---LVIQPtGGGEDYLPVAHTCFNLLDLPKYTDKETLKSKLIQAIDHYEGFSL 1055
           *******************...6666658899**************************************97 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MLCWGNASFG QLGLGGIDEE VVLEPRKSDF FLNKRVRDVG CGLRHTVFVL DDGTVYTCGC 60
NDLGQLGHDK ARKRPEHVGA LDAQNIVAVS CGEAHTLALN DKGQVYAWGL ATDGQLGLPG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGAAGCGA GTCACTGCTC CAGATGTGTG ACATGTGCTG TTGCGTAGCT GTGTCTTAAC 60
TGGAGACGTC TTCGTTTCGA TGTCCCCTTC TGAATGTGGT AGGATATAGC TAGGGAAATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0001650--C:fibrillar center
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007283--P:spermatogenesis

KEGG

fab:101811147

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	87.04	0.00e+00	1810.00
IUUC-Apl-003295	Anas platyrhynchos	95.65	0.00e+00	2041.00
IUUC-Aca-004336	Anolis carolinensis	85.66	0.00e+00	1847.00
IUUC-Ago-007908	Ashbya gossypii	33.33	8.00e-75	275.00
IUUC-Ame-010768	Astyanax mexicanus	72.52	0.00e+00	1570.00
IUUC-Bta-013279	Bos taurus	87.04	0.00e+00	1809.00
IUUC-Cel-018150	Caenorhabditis elegans	34.25	2.00e-156	546.00
IUUC-Cja-019023	Callithrix jacchus	86.94	0.00e+00	1805.00
IUUC-Cfa-021074	Canis familiaris	87.13	0.00e+00	1814.00
IUUC-Cpo-021461	Cavia porcellus	85.27	0.00e+00	1773.00
IUUC-Csa-024261	Chlorocebus sabaeus	87.51	0.00e+00	1816.00
IUUC-Cho-024513	Choloepus hoffmanni	69.63	0.00e+00	1340.00
IUUC-Cin-025232	Ciona intestinalis	42.90	0.00e+00	847.00
IUUC-Dre-028829	Danio rerio	74.06	0.00e+00	1537.00
IUUC-Dno-029445	Dasypus novemcinctus	84.22	0.00e+00	1455.00
IUUC-Dor-030158	Dipodomys ordii	86.81	0.00e+00	807.00
IUUC-Dme-032103	Drosophila melanogaster	46.00	0.00e+00	900.00
IUUC-Ete-033072	Echinops telfairi	78.22	0.00e+00	1598.00
IUUC-Eca-033317	Equus caballus	85.81	0.00e+00	1784.00
IUUC-Fca-035682	Felis catus	86.38	0.00e+00	1788.00
IUUC-Gmo-038671	Gadus morhua	72.05	0.00e+00	1545.00
IUUC-Gga-041174	Gallus gallus	95.27	0.00e+00	2038.00
IUUC-Gac-042600	Gasterosteus aculeatus	72.29	0.00e+00	1497.00
IUUC-Ggo-044589	Gorilla gorilla	87.13	0.00e+00	1832.00
IUUC-Hsa-046772	Homo sapiens	87.13	0.00e+00	1830.00
IUUC-Kpa-049152	Komagataella pastoris	36.90	6.00e-69	255.00
IUUC-Lch-050147	Latimeria chalumnae	80.46	0.00e+00	1434.00
IUUC-Loc-052684	Lepisosteus oculatus	78.81	0.00e+00	1670.00
IUUC-Laf-053844	Loxodonta africana	86.38	0.00e+00	1797.00
IUUC-Mcc-055531	Macaca mulatta	85.48	0.00e+00	1799.00
IUUC-Mga-060151	Meleagris gallopavo	95.06	0.00e+00	1706.00
IUUC-Mmr-060954	Microcebus murinus	87.42	0.00e+00	1816.00
IUUC-Mdo-062246	Monodelphis domestica	84.52	0.00e+00	1641.00
IUUC-Mmu-063369	Mus musculus	85.53	0.00e+00	1811.00
IUUC-Mpu-065936	Mustela putorius furo	86.86	0.00e+00	1665.00
IUUC-Mlu-067326	Myotis lucifugus	86.66	0.00e+00	1775.00
IUUC-Nle-069453	Nomascus leucogenys	86.38	0.00e+00	1784.00
IUUC-Ont-071720	Oreochromis niloticus	73.04	0.00e+00	1529.00
IUUC-Oan-073464	Ornithorhynchus anatinus	86.66	0.00e+00	1686.00
IUUC-Ocu-074207	Oryctolagus cuniculus	84.49	0.00e+00	1647.00
IUUC-Ola-086762	Oryzias latipes	72.52	0.00e+00	1488.00
IUUC-Oga-088435	Otolemur garnettii	87.23	0.00e+00	1811.00
IUUC-Oar-089233	Ovis aries	87.13	0.00e+00	1811.00
IUUC-Ptr-091368	Pan troglodytes	87.42	0.00e+00	1835.00
IUUC-Pan-092300	Papio anubis	87.51	0.00e+00	1816.00
IUUC-Psi-093406	Pelodiscus sinensis	90.73	0.00e+00	1956.00
IUUC-Pma-094113	Petromyzon marinus	70.89	0.00e+00	1150.00
IUUC-Pfo-097021	Poecilia formosa	71.51	0.00e+00	1565.00
IUUC-Pab-098327	Pongo abelii	87.23	0.00e+00	1831.00
IUUC-Pca-101075	Procavia capensis	81.82	0.00e+00	719.00
IUUC-Pva-102909	Pteropus vampyrus	77.20	0.00e+00	1529.00
IUUC-Rno-105457	Rattus norvegicus	86.47	0.00e+00	1838.00
IUUC-Sha-106632	Sarcophilus harrisii	85.62	0.00e+00	1808.00
IUUC-Sar-113679	Sorex araneus	77.07	0.00e+00	1001.00
IUUC-Tgu-116849	Taeniopygia guttata	93.28	0.00e+00	1969.00
IUUC-Tru-118206	Takifugu rubripes	71.09	0.00e+00	1455.00
IUUC-Tsy-119521	Tarsius syrichta	74.55	0.00e+00	1455.00
IUUC-Tni-120233	Tetraodon nigroviridis	71.29	0.00e+00	1454.00
IUUC-Tbe-127941	Tupaia belangeri	71.66	0.00e+00	1217.00
IUUC-Vpa-130448	Vicugna pacos	86.57	0.00e+00	1802.00
IUUC-Xtr-132719	Xenopus tropicalis	69.87	0.00e+00	1387.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence