iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-010601

Ensembl Protein ID

ENSAMXP00000000937.1

UniProt Accession

W5K027; W5K027_ASTMX

Genbank Protein ID

ENSAMXP00000000937

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01097036

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000000916.1	ENSAMXT00000000937.1	ENSAMXP00000000937.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.50e-136	454.2	520	852

Active Site

Position(s)	Description	Evidence
821	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s + np+hlk+F+f+Gr++++al++g+++d+
   Q: 520  PQDLRRRLWIIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASSI-NPDHLKYFKFIGRFIAMALFHGKFIDT 607
           5899********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k+l l+dle++dpe+y+sl +iken   +++e++l++ fsv++eilge++++eLkp+G ni Vt+eNkeeY++lv+e
   Q: 608  GFSLPFYKRILNKPLALKDLESIDPEFYNSLIWIKEN---NLQECELEMYFSVDKEILGEVTTHELKPDGGNILVTEENKEEYIRLVAE 693
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfnev+p++ l++F+++ele+++cG++eid++d++++t y++ y ++s++i+wFw++++e+++e+r ++LqFv
   Q: 694  WRLSRGVEEQTQAFFEGFNEVLPQQYLQYFDAKELEVMLCGMQEIDLSDWQRNTIYRH-YARSSKQIIWFWQFVKEMDNEKRMRLLQFV 781
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekL++Aieet+gF++
   Q: 782  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLTLAIEETEGFGQ 852
           *********************************************************************96 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MKAQLQIIVF SAKLKENKKN WFGPSPYVEV AVDGQSKKTE KCTNTHSPKW KQPLTVIVTP 60
FSKLIFRVWS HQTLKSDILL GMATLEVSET LKSNDMKICE VVRTLLLSTE RDGSDVVGDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTATTTAT TGTATAATTG TTTTAGTTTG CAGTTTATAT GCATGCACTA AATATTCTGC 60
AATATTATTT GCTGCATTAT ATTATTTTAT GCTATATTAT TTATTACACA TTATGATTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	89.18	0.00e+00	1109.00
IUUC-Apl-003752	Anas platyrhynchos	86.27	0.00e+00	1108.00
IUUC-Aca-005338	Anolis carolinensis	73.59	0.00e+00	1278.00
IUUC-Bta-012782	Bos taurus	89.35	0.00e+00	1110.00
IUUC-Cel-018299	Caenorhabditis elegans	65.46	0.00e+00	800.00
IUUC-Cja-018899	Callithrix jacchus	87.73	0.00e+00	1113.00
IUUC-Cpo-022073	Cavia porcellus	88.07	0.00e+00	1121.00
IUUC-Csa-023252	Chlorocebus sabaeus	86.71	0.00e+00	1109.00
IUUC-Cho-024695	Choloepus hoffmanni	87.56	0.00e+00	1117.00
IUUC-Cin-025212	Ciona intestinalis	66.32	0.00e+00	821.00
IUUC-Csv-026256	Ciona savignyi	65.92	0.00e+00	814.00
IUUC-Cne-026849	Cryptococcus neoformans	48.56	9.00e-160	557.00
IUUC-Dre-028809	Danio rerio	93.55	0.00e+00	1191.00
IUUC-Dno-029884	Dasypus novemcinctus	73.65	0.00e+00	1290.00
IUUC-Dor-030176	Dipodomys ordii	73.69	0.00e+00	893.00
IUUC-Dme-032041	Drosophila melanogaster	65.05	0.00e+00	805.00
IUUC-Ete-032779	Echinops telfairi	72.25	0.00e+00	858.00
IUUC-Eca-033793	Equus caballus	89.18	0.00e+00	1111.00
IUUC-Fal-037126	Ficedula albicollis	86.63	0.00e+00	1117.00
IUUC-Gmo-038596	Gadus morhua	84.50	0.00e+00	1049.00
IUUC-Gga-040832	Gallus gallus	86.63	0.00e+00	1113.00
IUUC-Gac-041520	Gasterosteus aculeatus	93.05	0.00e+00	1164.00
IUUC-Ggo-044535	Gorilla gorilla	85.01	0.00e+00	1084.00
IUUC-Hsa-046564	Homo sapiens	88.07	0.00e+00	1125.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	87.22	0.00e+00	1112.00
IUUC-Kpa-049273	Komagataella pastoris	49.83	1.00e-161	563.00
IUUC-Lch-050454	Latimeria chalumnae	88.72	0.00e+00	1122.00
IUUC-Loc-052647	Lepisosteus oculatus	79.18	0.00e+00	1397.00
IUUC-Laf-054383	Loxodonta africana	87.56	0.00e+00	1116.00
IUUC-Mcc-055532	Macaca mulatta	86.71	0.00e+00	1109.00
IUUC-Meu-055953	Macropus eugenii	63.93	0.00e+00	777.00
IUUC-Mga-059661	Meleagris gallopavo	86.63	0.00e+00	1112.00
IUUC-Mmr-061135	Microcebus murinus	88.07	0.00e+00	1124.00
IUUC-Mdo-062505	Monodelphis domestica	87.65	0.00e+00	1123.00
IUUC-Mmu-063375	Mus musculus	87.90	0.00e+00	1120.00
IUUC-Mpu-066203	Mustela putorius furo	89.18	0.00e+00	1108.00
IUUC-Mlu-067837	Myotis lucifugus	89.18	0.00e+00	1109.00
IUUC-Nle-069244	Nomascus leucogenys	87.22	0.00e+00	1111.00
IUUC-Opr-070585	Ochotona princeps	87.22	0.00e+00	1107.00
IUUC-Ont-071798	Oreochromis niloticus	93.40	0.00e+00	1179.00
IUUC-Oan-073497	Ornithorhynchus anatinus	75.93	0.00e+00	942.00
IUUC-Ocu-074298	Oryctolagus cuniculus	87.90	0.00e+00	1120.00
IUUC-Ola-086526	Oryzias latipes	89.36	0.00e+00	1145.00
IUUC-Oar-089317	Ovis aries	75.95	0.00e+00	926.00
IUUC-Ptr-090819	Pan troglodytes	86.88	0.00e+00	1088.00
IUUC-Pan-092454	Papio anubis	86.71	0.00e+00	1110.00
IUUC-Psi-093319	Pelodiscus sinensis	72.18	0.00e+00	1240.00
IUUC-Pma-094279	Petromyzon marinus	66.12	0.00e+00	766.00
IUUC-Pfo-096937	Poecilia formosa	93.33	0.00e+00	1167.00
IUUC-Pab-097580	Pongo abelii	84.04	0.00e+00	982.00
IUUC-Pca-100923	Procavia capensis	78.71	0.00e+00	981.00
IUUC-Pva-103209	Pteropus vampyrus	88.48	0.00e+00	1091.00
IUUC-Rno-104924	Rattus norvegicus	87.73	0.00e+00	1121.00
IUUC-Sha-107175	Sarcophilus harrisii	86.42	0.00e+00	1123.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	47.88	2.00e-151	530.00
IUUC-Sar-113761	Sorex araneus	88.83	0.00e+00	1102.00
IUUC-Ssc-115368	Sus scrofa	74.58	0.00e+00	926.00
IUUC-Tgu-116632	Taeniopygia guttata	82.62	0.00e+00	1019.00
IUUC-Tru-118442	Takifugu rubripes	90.83	0.00e+00	1134.00
IUUC-Tsy-119198	Tarsius syrichta	79.39	0.00e+00	987.00
IUUC-Tni-120168	Tetraodon nigroviridis	92.34	0.00e+00	1112.00
IUUC-Tbe-127756	Tupaia belangeri	76.60	0.00e+00	818.00
IUUC-Ttr-128275	Tursiops truncatus	73.87	0.00e+00	895.00
IUUC-Vpa-130103	Vicugna pacos	75.30	0.00e+00	931.00
IUUC-Xtr-132885	Xenopus tropicalis	87.18	0.00e+00	1107.00
IUUC-Xma-133987	Xiphophorus maculatus	93.16	0.00e+00	1165.00
IUUC-Yli-134668	Yarrowia lipolytica	46.17	8.00e-155	541.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence