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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-031929
Ensembl Protein ID FBpp0113009
UniProt Accession O02194; O02395; O76802; O96340; Q9TY80; Q9V3L9; Q9V3S1; PSN_DROME
Genbank Protein ID AAB61139.1; AAB53369.1; AAC33129.1; AAC33128.1; AAD01610.1; AAD01611.1; AAD01612.1; AAD52707.1; AAD52708.1; AAN12132.1; AAF51598.1; AAL28864.1
Protein Name Presenilin homolog; dPS
Genbank Nucleotide ID U77934; U78084; AF084184; AF084184; AF017024; AF017025; AF017026; AF093402; AF093402; AE014296; AE014296; AY061316
Gene Name Psn; PS; CG18803
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0019947 FBtr0078192 FBpp0077850
FBgn0019947 FBtr0333478 FBpp0305665
FBgn0019947 FBtr0114517 FBpp0113009
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IIDPINAMentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/CUE 50.58 2.00e-97 353.00 IUUC-Cel-018553
UBD/Alpha-Helix/CUE 56.04 4.00e-108 389.00 IUUC-Hsa-046822
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes.
 Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptor. Required for S3 cleavage of Notch, which releases activated Notch protein from the cell membrane. Involved in the patterning of the optic lobes.
Protein Sequence
(Fasta)
MAAVNLQASC SSGLASEDDA NVGSQIGAAE RLERPPRRQQ QRNNYGSSNQ DQPDAAILAV 60
PNVVMREPCG SRPSRLTGGG GGSGGPPTNE MEEEQGLKYG AQHVIKLFVP VSLCMLVVVA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-031929|UBD,CUE|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAAGGGGTTC CTTTTAGAGT CATAAAAAAT TGTGAGTTGA CAAAGTCGCC ACTTTTAATT 60
TGTGCATGAT TGCATGTAGA AGTTATTCTA AATACTTGTA CCTTAAATAT ATTAATCCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-031929|UBD,CUE|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP
Pfam

PF01080--Presenilin
PRINTS

PR01072--PRESENILIN
SMART

SM00730--PSN
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0030018--C:Z disc
GO:0004190--F:aspartic-type endopeptidase activity
GO:0004175--F:endopeptidase activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0006915--P:apoptotic process
GO:0050435--P:beta-amyloid metabolic process
GO:0006816--P:calcium ion transport
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing
KEGG dme:Dmel_CG18803
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000686 Aegilops tauschii 33.26 1.00e-26 114.00
IUUC-Aml-001648 Ailuropoda melanoleuca 54.40 4.00e-83 300.00
IUUC-Atr-003039 Amborella trichopoda 30.89 3.00e-40 158.00
IUUC-Apl-003727 Anas platyrhynchos 56.63 9.00e-99 353.00
IUUC-Aca-004582 Anolis carolinensis 55.64 3.00e-101 361.00
IUUC-Aly-005455 Arabidopsis lyrata 31.46 9.00e-20 90.50
IUUC-Ath-006730 Arabidopsis thaliana 30.99 1.00e-20 93.20
IUUC-Ago-007845 Ashbya gossypii 36.59 3.80e-01 29.30
IUUC-Ame-010686 Astyanax mexicanus 53.41 3.00e-104 370.00
IUUC-Bta-013026 Bos taurus 55.31 9.00e-100 356.00
IUUC-Bdi-014196 Brachypodium distachyon 31.95 2.00e-35 142.00
IUUC-Bol-015841 Brassica oleracea 30.65 2.00e-31 129.00
IUUC-Bra-017580 Brassica rapa 44.80 1.00e-17 83.60
IUUC-Cel-018553 Caenorhabditis elegans 51.86 1.00e-95 342.00
IUUC-Cja-019994 Callithrix jacchus 55.77 1.00e-97 348.00
IUUC-Cfa-020074 Canis familiaris 56.04 2.00e-98 352.00
IUUC-Cpo-022237 Cavia porcellus 55.80 1.00e-98 352.00
IUUC-Cre-022747 Chlamydomonas reinhardtii 33.77 1.00e-30 127.00
IUUC-Csa-023537 Chlorocebus sabaeus 55.88 4.00e-98 350.00
IUUC-Cho-024735 Choloepus hoffmanni 50.24 5.00e-88 317.00
IUUC-Cin-025780 Ciona intestinalis 53.48 3.00e-107 381.00
IUUC-Csv-025967 Ciona savignyi 55.48 8.00e-109 385.00
IUUC-Dre-028526 Danio rerio 54.35 2.00e-101 362.00
IUUC-Dno-029758 Dasypus novemcinctus 55.24 4.00e-97 347.00
IUUC-Dor-031127 Dipodomys ordii 55.09 1.00e-78 286.00
IUUC-Ete-032487 Echinops telfairi 49.78 3.00e-35 142.00
IUUC-Eca-034387 Equus caballus 63.60 6.00e-79 287.00
IUUC-Eeu-035134 Erinaceus europaeus 56.10 1.00e-76 278.00
IUUC-Fca-036243 Felis catus 55.40 7.00e-99 353.00
IUUC-Fal-036600 Ficedula albicollis 56.35 5.00e-100 357.00
IUUC-Gmo-039665 Gadus morhua 52.59 7.00e-82 296.00
IUUC-Gga-040993 Gallus gallus 56.83 6.00e-101 360.00
IUUC-Gac-042511 Gasterosteus aculeatus 53.27 1.00e-94 339.00
IUUC-Gma-043822 Glycine max 60.53 1.00e-15 76.30
IUUC-Ggo-045338 Gorilla gorilla 52.70 3.00e-85 308.00
IUUC-Hsa-046822 Homo sapiens 55.88 4.00e-98 350.00
IUUC-Hvu-047141 Hordeum vulgare 33.33 9.00e-28 117.00
IUUC-Itr-048420 Ictidomys tridecemlineatus 56.56 3.00e-82 297.00
IUUC-Lch-049946 Latimeria chalumnae 49.29 1.00e-78 286.00
IUUC-Lpe-051132 Leersia perrieri 39.13 3.00e-19 89.00
IUUC-Loc-052427 Lepisosteus oculatus 54.18 3.00e-101 360.00
IUUC-Laf-053758 Loxodonta africana 48.00 2.00e-104 371.00
IUUC-Mcc-055682 Macaca mulatta 55.88 4.00e-98 350.00
IUUC-Meu-056004 Macropus eugenii 49.31 3.00e-67 248.00
IUUC-Mtr-058392 Medicago truncatula 32.89 6.00e-30 124.00
IUUC-Mga-059466 Meleagris gallopavo 56.83 4.00e-101 360.00
IUUC-Mmr-060890 Microcebus murinus 54.10 3.00e-85 308.00
IUUC-Mdo-062122 Monodelphis domestica 56.04 7.00e-98 350.00
IUUC-Mmu-063176 Mus musculus 52.33 8.00e-94 336.00
IUUC-Mac-064858 Musa acuminata 57.47 2.00e-16 79.00
IUUC-Mpu-065927 Mustela putorius furo 55.40 7.00e-99 353.00
IUUC-Mlu-067079 Myotis lucifugus 56.04 6.00e-106 376.00
IUUC-Nle-070180 Nomascus leucogenys 55.88 4.00e-98 350.00
IUUC-Opr-070847 Ochotona princeps 53.38 2.00e-95 342.00
IUUC-Ont-071846 Oreochromis niloticus 56.14 3.00e-97 348.00
IUUC-Oan-072783 Ornithorhynchus anatinus 53.17 2.00e-75 275.00
IUUC-Ocu-074527 Oryctolagus cuniculus 55.64 1.00e-99 356.00
IUUC-Oba-075256 Oryza barthii 58.54 2.00e-16 79.00
IUUC-Obr-076302 Oryza brachyantha 38.41 2.00e-18 86.30
IUUC-Ogl-077097 Oryza glaberrima 38.41 4.00e-18 85.10
IUUC-Ogu-078570 Oryza glumaepatula 38.41 4.00e-18 85.10
IUUC-Oin-079244 Oryza indica 38.41 3.00e-18 85.90
IUUC-Olo-080484 Oryza longistaminata 60.76 2.00e-16 79.00
IUUC-Ome-081814 Oryza meridionalis 38.41 3.00e-18 85.90
IUUC-Oni-082057 Oryza nivara 38.41 3.00e-18 85.50
IUUC-Opu-084176 Oryza punctata 39.13 5.00e-18 84.70
IUUC-Oru-084618 Oryza rufipogon 38.41 3.00e-18 85.50
IUUC-Osa-085602 Oryza sativa 38.41 3.00e-18 85.50
IUUC-Ola-086707 Oryzias latipes 65.28 1.00e-78 285.00
IUUC-Olu-087811 Ostreococcus lucimarinus 32.58 4.00e-41 160.00
IUUC-Oga-088560 Otolemur garnettii 52.26 8.00e-85 306.00
IUUC-Oar-090348 Ovis aries 54.68 2.00e-100 358.00
IUUC-Ptr-091060 Pan troglodytes 55.88 4.00e-98 350.00
IUUC-Pan-091855 Papio anubis 54.55 2.00e-94 338.00
IUUC-Psi-093505 Pelodiscus sinensis 56.04 2.00e-99 355.00
IUUC-Pma-094612 Petromyzon marinus 56.14 7.00e-91 326.00
IUUC-Ppa-095431 Physcomitrella patens 34.51 7.00e-28 117.00
IUUC-Pfo-097396 Poecilia formosa 54.68 1.00e-102 365.00
IUUC-Pab-098591 Pongo abelii 55.88 3.00e-98 351.00
IUUC-Pop-099661 Populus trichocarpa 34.54 4.00e-39 154.00
IUUC-Pca-101029 Procavia capensis 57.00 1.00e-89 322.00
IUUC-Ppe-101495 Prunus persica 34.23 7.00e-24 104.00
IUUC-Pva-102244 Pteropus vampyrus 54.11 7.00e-99 353.00
IUUC-Rno-105861 Rattus norvegicus 64.73 2.00e-73 268.00
IUUC-Sha-107045 Sarcophilus harrisii 56.76 4.00e-99 353.00
IUUC-Smo-109325 Selaginella moellendorffii 34.23 2.00e-36 145.00
IUUC-Sit-110624 Setaria italica 55.56 2.00e-16 79.70
IUUC-Sly-110865 Solanum lycopersicum 53.33 9.00e-07 44.30
IUUC-Stu-112433 Solanum tuberosum 32.77 1.00e-29 123.00
IUUC-Sar-113169 Sorex araneus 50.26 2.00e-74 272.00
IUUC-Sbi-114305 Sorghum bicolor 35.37 4.00e-28 118.00
IUUC-Ssc-115766 Sus scrofa 55.77 2.00e-99 355.00
IUUC-Tgu-117280 Taeniopygia guttata 53.62 2.00e-96 345.00
IUUC-Tru-117732 Takifugu rubripes 55.05 4.00e-98 350.00
IUUC-Tsy-119624 Tarsius syrichta 52.05 1.00e-89 322.00
IUUC-Tni-119852 Tetraodon nigroviridis 51.55 1.00e-90 325.00
IUUC-Tca-121865 Theobroma cacao 30.63 6.00e-34 137.00
IUUC-Tae-125925 Triticum aestivum 33.26 2.00e-27 116.00
IUUC-Tur-126237 Triticum urartu 34.78 5.00e-27 114.00
IUUC-Tbe-127632 Tupaia belangeri 52.58 5.00e-85 307.00
IUUC-Ttr-128793 Tursiops truncatus 55.16 3.00e-95 341.00
IUUC-Vpa-130625 Vicugna pacos 47.34 6.00e-81 293.00
IUUC-Vvi-131312 Vitis vinifera 31.63 2.00e-35 142.00
IUUC-Xtr-132756 Xenopus tropicalis 53.46 1.00e-108 385.00
IUUC-Xma-133377 Xiphophorus maculatus 54.22 5.00e-101 360.00
Created Date 25-Jun-2017

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