iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093726

Ensembl Protein ID

ENSPSIP00000006417.1

UniProt Accession

K7FEF7; K7FEF7_PELSI

Genbank Protein ID

ENSPSIP00000006417

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AGCU01121697

Gene Name

USP20

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000005924.1	ENSPSIT00000006454.1	ENSPSIP00000006417.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.00e-111	371.9	145	679

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kNlgN+CYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++e+w k++ ++v p++l + +k ++++f+gy+
   Q: 145  TGMKNLGNSCYMNAALQALSNCPPLTQFFLE-----CGGLVRTDKKPALCKSYQKLVSEVWhKKRPSYVVPSSLSHGIKLVNPMFRGYA 228
           7******************************.....999999*******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkk........eknkpkeeeeeedkselsde........................................ 129
           qqD+qEfl++l+dql+eelk+        ++++++++           +                                        
   Q: 229  QQDTQEFLRCLMDQLHEELKEpvvaeardSDSSDIDD-----------Kregdrspsedeflscdsssdrgdmdgqgrtggmsgslaet 306
           *******************775555544444444444...........444455555555***************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 307  elliqdeagrgisekermkdrkfsyshrrsnseqvdedadvdttmmpidgraspetlpaprpaspcrtpepdndayvrcssrpcspahq 395
           ***************************************************************************************** PP
   S: 130  ................................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke. 185
                                            ++kk+ +++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +k+ 
   Q: 396  emhcklssspprsspvrlgpsyvlkkaqvlasGKKKKELRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLh 484
           *******************************9999999*********************************************99888* PP
   S: 186  ................................................slqdcLesftkeeelegenkyycekckkkqeaekklklkkl 226
                                                           +l+dcL++f++++el+g+n+y+ce+ckk+++ +k +k+ +l
   Q: 485  saiyqnvpakpgacgdnyssqgwiafimeyirrfvvscipswfwgpvvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRL 573
           ***************************************************************************************** PP
   S: 227  PevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDsk 313
           Pe+L++hLkRf  ++e + + kin++v+fple Ldl+pf+++++ +q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD++
   Q: 574  PEILCIHLKRF--RHEVMYSFKINSHVSFPLEgLDLRPFLAKECVSQ--ITTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDDQY 658
           ***********..9999*************************99888..9**************************78999******** PP
   S: 314  VtevkeeevleetgstaYvlfYkr 337
           Vtev+e+ v++   ++aYvlfY++
   Q: 659  VTEVHETVVQN---AEAYVLFYRK 679
           ***********...********98 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MGDTRDVCPH LDSIGEVSKD DLLLKSKGTC QSCRAAGPNL WACLQVACPY VGCGESFADH 60
STLHAQAKKH NLTVNLTTFR VWCYACEKEV FLDQRLAVHT PSPPAKFSEQ DAPLPAHPLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATCCAACGA TGCTGTGTGA TCCAGAGAAG CTGGGACTTT GAGCCTTCAG AAGAGAGTAC 60
TCAGTGGTTC GTCACATTAT CATCTTCCTT TGAGGTAGGA ATGAATCAGC AAATCCAAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP

Gene Ontology

GO:0005813--C:centrosome
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	85.61	0.00e+00	1532.00
IUUC-Apl-003351	Anas platyrhynchos	93.64	0.00e+00	1712.00
IUUC-Aca-005077	Anolis carolinensis	80.19	0.00e+00	1140.00
IUUC-Ame-011777	Astyanax mexicanus	76.22	0.00e+00	1345.00
IUUC-Bta-013063	Bos taurus	86.35	0.00e+00	1533.00
IUUC-Cja-019868	Callithrix jacchus	86.49	0.00e+00	1563.00
IUUC-Cfa-020761	Canis familiaris	85.61	0.00e+00	1554.00
IUUC-Cpo-022267	Cavia porcellus	81.26	0.00e+00	1445.00
IUUC-Csa-024251	Chlorocebus sabaeus	87.45	0.00e+00	1581.00
IUUC-Cho-024483	Choloepus hoffmanni	92.92	8.00e-121	427.00
IUUC-Dre-028061	Danio rerio	75.24	0.00e+00	1215.00
IUUC-Dno-029423	Dasypus novemcinctus	87.66	0.00e+00	1566.00
IUUC-Dor-030877	Dipodomys ordii	85.50	0.00e+00	1019.00
IUUC-Dme-031837	Drosophila melanogaster	49.36	5.00e-140	491.00
IUUC-Ete-032802	Echinops telfairi	76.00	1.00e-134	473.00
IUUC-Eca-034283	Equus caballus	85.71	0.00e+00	1557.00
IUUC-Eeu-034620	Erinaceus europaeus	84.26	0.00e+00	1065.00
IUUC-Fca-036357	Felis catus	86.37	0.00e+00	1531.00
IUUC-Fal-037411	Ficedula albicollis	93.63	0.00e+00	1696.00
IUUC-Gga-041101	Gallus gallus	92.74	0.00e+00	1688.00
IUUC-Gac-041315	Gasterosteus aculeatus	74.68	0.00e+00	1323.00
IUUC-Ggo-045600	Gorilla gorilla	85.78	0.00e+00	1533.00
IUUC-Hsa-045825	Homo sapiens	87.23	0.00e+00	1548.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	74.68	0.00e+00	1284.00
IUUC-Lch-050002	Latimeria chalumnae	77.52	0.00e+00	1353.00
IUUC-Loc-052574	Lepisosteus oculatus	78.69	0.00e+00	1413.00
IUUC-Laf-054428	Loxodonta africana	87.04	0.00e+00	1563.00
IUUC-Mcc-055736	Macaca mulatta	87.23	0.00e+00	1576.00
IUUC-Mga-059781	Meleagris gallopavo	91.92	0.00e+00	1687.00
IUUC-Mdo-063048	Monodelphis domestica	91.65	0.00e+00	1594.00
IUUC-Mmu-064079	Mus musculus	82.46	0.00e+00	1528.00
IUUC-Mpu-066616	Mustela putorius furo	84.98	0.00e+00	1579.00
IUUC-Mlu-067294	Myotis lucifugus	84.84	0.00e+00	1482.00
IUUC-Nle-070015	Nomascus leucogenys	87.45	0.00e+00	1539.00
IUUC-Opr-070328	Ochotona princeps	85.82	0.00e+00	1551.00
IUUC-Ont-071464	Oreochromis niloticus	77.35	0.00e+00	1323.00
IUUC-Oan-073259	Ornithorhynchus anatinus	82.32	0.00e+00	1380.00
IUUC-Ocu-074630	Oryctolagus cuniculus	83.33	0.00e+00	1476.00
IUUC-Ola-087240	Oryzias latipes	76.99	0.00e+00	1306.00
IUUC-Oga-088761	Otolemur garnettii	85.42	0.00e+00	1555.00
IUUC-Oar-089490	Ovis aries	82.31	0.00e+00	1404.00
IUUC-Ptr-091662	Pan troglodytes	87.23	0.00e+00	1544.00
IUUC-Pan-092199	Papio anubis	86.06	0.00e+00	1568.00
IUUC-Pma-094389	Petromyzon marinus	64.73	6.00e-101	360.00
IUUC-Pab-098632	Pongo abelii	87.12	0.00e+00	1539.00
IUUC-Pca-100614	Procavia capensis	79.95	0.00e+00	1193.00
IUUC-Pva-102922	Pteropus vampyrus	83.36	0.00e+00	876.00
IUUC-Rno-105215	Rattus norvegicus	82.77	0.00e+00	1535.00
IUUC-Sce-106176	Saccharomyces cerevisiae	31.18	3.00e-25	110.00
IUUC-Sha-106601	Sarcophilus harrisii	89.97	0.00e+00	1558.00
IUUC-Ssc-115533	Sus scrofa	83.69	0.00e+00	1522.00
IUUC-Tgu-117364	Taeniopygia guttata	93.39	0.00e+00	1651.00
IUUC-Tru-117770	Takifugu rubripes	74.78	0.00e+00	1305.00
IUUC-Tni-120001	Tetraodon nigroviridis	74.81	0.00e+00	1278.00
IUUC-Ttr-128732	Tursiops truncatus	86.48	0.00e+00	1543.00
IUUC-Xtr-132157	Xenopus tropicalis	78.00	0.00e+00	1389.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence