iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012826

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Cytokine-inducible SH2-containing protein

Genbank Nucleotide ID

BC113307

Gene Name

CISH

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000022622.3	ENSBTAT00000030652.3	ENSBTAP00000030624.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	2.40e-14	53.1	206	253

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           l++++++rs+ rSLqhLCRl+I+r++ +     +d+LPLP+++ dYL+++++q
   Q: 206  LVQPFVRRSSTRSLQHLCRLVINRLVVD-----VDCLPLPRRMADYLRQYPFQ 253
           57899***********************.....8****************986 PP

Organism

Bos taurus

Functional Description
(View)

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation (By similarity). May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Protein Sequence
(Fasta)

MVLCVQGLCP LLAVEQIGQR PLWAQSLELP QQVMQPLSAG AFLEEAVEES PAQPEREPKV 60
VDPEEDLLCI AKTFSYLRES GWYWGSITAS EARQHLQKMP EGTFLVRDST HPSYLFTLSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGAGCCTG CCCTGCGAGC GCGATCCGCG CCCACTGGCT CATTCCAGCC GCCGCCGTCA 60
GGCCGAGCCT CAGCTCCGGA GCAACAGCTG CCGCTGCCGG GACATGGTCC TCTGCGTTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0341--Growth regulation
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway

Interpro

IPR028425--CIS
IPR000980--SH2
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

PRINTS

PR00401--SH2DOMAIN

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0007205--P:protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth

KEGG

bta:616753

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001189	Ailuropoda melanoleuca	92.37	1.00e-119	422.00
IUUC-Aca-004372	Anolis carolinensis	63.81	4.00e-87	313.00
IUUC-Ame-010787	Astyanax mexicanus	45.67	4.00e-49	187.00
IUUC-Cja-020004	Callithrix jacchus	87.55	2.00e-111	395.00
IUUC-Cfa-020150	Canis familiaris	89.16	3.00e-111	394.00
IUUC-Csa-023173	Chlorocebus sabaeus	88.76	2.00e-113	401.00
IUUC-Dre-028606	Danio rerio	47.06	8.00e-34	136.00
IUUC-Dno-028956	Dasypus novemcinctus	85.94	7.00e-120	422.00
IUUC-Dor-030148	Dipodomys ordii	73.62	1.00e-97	348.00
IUUC-Ete-032313	Echinops telfairi	80.78	3.00e-100	357.00
IUUC-Eca-033422	Equus caballus	92.22	3.00e-131	460.00
IUUC-Eeu-034806	Erinaceus europaeus	87.95	4.00e-109	387.00
IUUC-Fca-036374	Felis catus	88.72	4.00e-122	430.00
IUUC-Fal-036801	Ficedula albicollis	64.59	1.00e-85	309.00
IUUC-Gmo-038483	Gadus morhua	38.19	9.00e-36	143.00
IUUC-Gga-040891	Gallus gallus	65.23	1.00e-82	299.00
IUUC-Gac-042147	Gasterosteus aculeatus	39.62	6.00e-36	144.00
IUUC-Ggo-045511	Gorilla gorilla	87.60	3.00e-110	390.00
IUUC-Hsa-046678	Homo sapiens	87.60	1.00e-113	402.00
IUUC-Itr-048397	Ictidomys tridecemlineatus	91.44	5.00e-130	456.00
IUUC-Lch-050555	Latimeria chalumnae	56.42	2.00e-72	265.00
IUUC-Laf-054141	Loxodonta africana	86.43	2.00e-120	424.00
IUUC-Mcc-055401	Macaca mulatta	87.95	1.00e-111	395.00
IUUC-Meu-056592	Macropus eugenii	68.29	1.00e-89	322.00
IUUC-Mga-059515	Meleagris gallopavo	65.18	1.00e-78	286.00
IUUC-Mmr-060848	Microcebus murinus	90.36	1.00e-119	422.00
IUUC-Mdo-062720	Monodelphis domestica	66.54	2.00e-90	324.00
IUUC-Mmu-063348	Mus musculus	88.72	3.00e-130	457.00
IUUC-Mpu-065834	Mustela putorius furo	90.66	5.00e-121	426.00
IUUC-Mlu-067687	Myotis lucifugus	85.60	6.00e-102	363.00
IUUC-Nle-069277	Nomascus leucogenys	87.21	1.00e-113	402.00
IUUC-Ont-071890	Oreochromis niloticus	48.15	1.00e-37	149.00
IUUC-Oan-073672	Ornithorhynchus anatinus	66.02	2.00e-87	315.00
IUUC-Ocu-073875	Oryctolagus cuniculus	89.96	8.00e-121	426.00
IUUC-Ola-087140	Oryzias latipes	43.92	2.00e-26	111.00
IUUC-Oga-087943	Otolemur garnettii	89.11	4.00e-121	427.00
IUUC-Oar-090194	Ovis aries	96.75	6.00e-132	462.00
IUUC-Ptr-090934	Pan troglodytes	87.55	1.00e-108	385.00
IUUC-Pan-092121	Papio anubis	87.60	2.00e-115	407.00
IUUC-Psi-093733	Pelodiscus sinensis	62.35	4.00e-84	303.00
IUUC-Pfo-096313	Poecilia formosa	48.31	2.00e-44	171.00
IUUC-Pab-098439	Pongo abelii	87.21	1.00e-112	399.00
IUUC-Pca-101010	Procavia capensis	87.21	6.00e-122	429.00
IUUC-Pva-103112	Pteropus vampyrus	88.72	2.00e-125	441.00
IUUC-Rno-105917	Rattus norvegicus	89.49	6.00e-118	416.00
IUUC-Sha-106954	Sarcophilus harrisii	66.15	8.00e-92	329.00
IUUC-Smo-109292	Selaginella moellendorffii	31.15	1.50e-01	31.20
IUUC-Sar-113001	Sorex araneus	89.56	5.00e-116	410.00
IUUC-Ssc-115922	Sus scrofa	92.20	2.00e-65	240.00
IUUC-Tgu-117338	Taeniopygia guttata	64.52	1.00e-82	298.00
IUUC-Tru-118511	Takifugu rubripes	45.45	1.00e-33	135.00
IUUC-Tsy-119434	Tarsius syrichta	89.16	9.00e-115	405.00
IUUC-Ttr-128340	Tursiops truncatus	81.10	5.00e-92	330.00
IUUC-Vpa-130443	Vicugna pacos	92.13	6.00e-136	476.00
IUUC-Xtr-131784	Xenopus tropicalis	54.28	5.00e-70	257.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence