iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-117742

Ensembl Protein ID

ENSTRUP00000001709.1

UniProt Accession

H2RNJ6; H2RNJ6_TAKRU

Protein Name

Phosphoinositide phospholipase C

Gene Name

plcg1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000000710.1	ENSTRUT00000001716.1	ENSTRUP00000001708.1
ENSTRUG00000000710.1	ENSTRUT00000001717.1	ENSTRUP00000001709.1
ENSTRUG00000000710.1	ENSTRUT00000001718.1	ENSTRUP00000001710.1
ENSTRUG00000000710.1	ENSTRUT00000001719.1	ENSTRUP00000001711.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.10e-11	44.8	787	845

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGl.fPenFvekle 63
           +k +v+++y+y+aq ddeL+++k  +++ +  ++q++gW+kg  +  gk+ l fP+n+ve+++
   Q: 787  FKCTVRAMYEYKAQRDDELSFTKNAIIYNV--DKQEGGWWKG--DCGGKKQLwFPANYVEEIS 845
           67789************************9..9*********..777777666*******986 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MAGTSGFFSN GPVPWMDNDA EINNLYRDLE LGTVLTLFYS KKSQRPERRT FQVKLETRTI 60
IWTRGTDKIE GEIDIREIKE IRPGQKSRDF ERYLEDSAAR LDQAHCFVIL YGTEFRLKSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGGAA CCTCGGGCTT CTTTTCCAAC GGACCCGTTC CGTGGATGGA CAACGATGCC 60
GAGATTAACA ACCTGTATCG AGACCTGGAG CTGGGAACAG TGCTCACGCT GTTTTATTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0807--Transducer

Interpro

IPR000008--C2_dom
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001192--PI-PLC_fam
IPR016279--PLC-gamma
IPR028380--PLC-gamma1
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR001711--PLipase_C_Pinositol-sp_Y
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50004--C2
PS00018--EF_HAND_1
PS50003--PH_DOMAIN
PS50007--PIPLC_X_DOMAIN
PS50008--PIPLC_Y_DOMAIN
PS50001--SH2
PS50002--SH3

Pfam

PF00168--C2
PF00388--PI-PLC-X
PF00387--PI-PLC-Y
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00390--PHPHLIPASEC
PR00401--SH2DOMAIN

SMART

SM00239--C2
SM00233--PH
SM00148--PLCXc
SM00149--PLCYc
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005622--C:intracellular
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0004871--F:signal transducer activity
GO:0001525--P:angiogenesis
GO:0048844--P:artery morphogenesis
GO:0031101--P:fin regeneration
GO:0030851--P:granulocyte differentiation
GO:0060218--P:hematopoietic stem cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0009395--P:phospholipid catabolic process
GO:0035477--P:regulation of angioblast cell migration involved in selective angioblast sprouting
GO:0008016--P:regulation of heart contraction
GO:0001570--P:vasculogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001452	Ailuropoda melanoleuca	73.16	0.00e+00	2020.00
IUUC-Apl-003541	Anas platyrhynchos	66.26	0.00e+00	1737.00
IUUC-Aca-005291	Anolis carolinensis	74.30	0.00e+00	2008.00
IUUC-Ame-011004	Astyanax mexicanus	78.61	0.00e+00	2082.00
IUUC-Bta-012660	Bos taurus	74.16	0.00e+00	1922.00
IUUC-Cja-019206	Callithrix jacchus	73.69	0.00e+00	2008.00
IUUC-Cfa-020257	Canis familiaris	74.16	0.00e+00	1939.00
IUUC-Cpo-022391	Cavia porcellus	69.03	0.00e+00	1846.00
IUUC-Csa-024170	Chlorocebus sabaeus	76.89	0.00e+00	1510.00
IUUC-Cin-025520	Ciona intestinalis	46.91	0.00e+00	1087.00
IUUC-Dre-027944	Danio rerio	82.72	0.00e+00	2201.00
IUUC-Dno-029440	Dasypus novemcinctus	73.72	0.00e+00	1843.00
IUUC-Dor-031001	Dipodomys ordii	73.38	0.00e+00	2017.00
IUUC-Eca-033809	Equus caballus	74.32	0.00e+00	1940.00
IUUC-Fca-036510	Felis catus	74.08	0.00e+00	1944.00
IUUC-Fal-037541	Ficedula albicollis	75.15	0.00e+00	1848.00
IUUC-Gmo-038630	Gadus morhua	75.04	0.00e+00	1665.00
IUUC-Gga-040142	Gallus gallus	74.60	0.00e+00	1998.00
IUUC-Ggo-045063	Gorilla gorilla	73.83	0.00e+00	2030.00
IUUC-Hsa-046428	Homo sapiens	73.76	0.00e+00	2029.00
IUUC-Itr-048245	Ictidomys tridecemlineatus	74.38	0.00e+00	1999.00
IUUC-Lch-049766	Latimeria chalumnae	75.79	0.00e+00	1935.00
IUUC-Loc-052285	Lepisosteus oculatus	83.80	0.00e+00	2300.00
IUUC-Laf-053365	Loxodonta africana	74.08	0.00e+00	1927.00
IUUC-Mcc-054871	Macaca mulatta	73.90	0.00e+00	2015.00
IUUC-Meu-056724	Macropus eugenii	70.12	0.00e+00	1778.00
IUUC-Mga-059329	Meleagris gallopavo	73.79	0.00e+00	1884.00
IUUC-Mmr-061110	Microcebus murinus	73.45	0.00e+00	2010.00
IUUC-Mdo-062448	Monodelphis domestica	74.06	0.00e+00	2032.00
IUUC-Mmu-063565	Mus musculus	73.48	0.00e+00	2009.00
IUUC-Mpu-066683	Mustela putorius furo	73.91	0.00e+00	2034.00
IUUC-Mlu-067779	Myotis lucifugus	73.92	0.00e+00	1928.00
IUUC-Nle-069219	Nomascus leucogenys	78.24	0.00e+00	1747.00
IUUC-Opr-070766	Ochotona princeps	69.07	0.00e+00	1127.00
IUUC-Ont-072524	Oreochromis niloticus	90.44	0.00e+00	2387.00
IUUC-Oan-073214	Ornithorhynchus anatinus	70.00	2.00e-36	144.00
IUUC-Ocu-074361	Oryctolagus cuniculus	73.36	0.00e+00	1980.00
IUUC-Ola-086820	Oryzias latipes	87.81	0.00e+00	2372.00
IUUC-Oga-088172	Otolemur garnettii	73.60	0.00e+00	2024.00
IUUC-Oar-090306	Ovis aries	71.85	0.00e+00	1857.00
IUUC-Ptr-090682	Pan troglodytes	73.91	0.00e+00	2030.00
IUUC-Pan-092835	Papio anubis	74.16	0.00e+00	1456.00
IUUC-Psi-093344	Pelodiscus sinensis	73.81	0.00e+00	1991.00
IUUC-Pfo-096984	Poecilia formosa	85.87	0.00e+00	2271.00
IUUC-Pab-097871	Pongo abelii	74.46	0.00e+00	2005.00
IUUC-Pca-100772	Procavia capensis	67.72	0.00e+00	1826.00
IUUC-Pva-102790	Pteropus vampyrus	74.32	0.00e+00	1984.00
IUUC-Rno-105974	Rattus norvegicus	73.53	0.00e+00	2028.00
IUUC-Sar-112995	Sorex araneus	73.23	0.00e+00	1966.00
IUUC-Ssc-115360	Sus scrofa	73.80	0.00e+00	2020.00
IUUC-Tgu-116585	Taeniopygia guttata	71.90	0.00e+00	1895.00
IUUC-Tsy-119259	Tarsius syrichta	77.73	0.00e+00	702.00
IUUC-Tni-120553	Tetraodon nigroviridis	95.42	0.00e+00	1724.00
IUUC-Tbe-127504	Tupaia belangeri	66.24	0.00e+00	1099.00
IUUC-Xtr-132862	Xenopus tropicalis	69.71	0.00e+00	1855.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence